PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18497086-9 2008 In the presence of the ligand, ciprofibrate, PEDF binding to PPARalpha decreases whereas the presence of troglitazone does not alter PEDF interactions with PPARgamma. ciprofibrate 31-43 peroxisome proliferator activated receptor alpha Homo sapiens 61-70 16554032-1 2006 Ciprofibrate, a potent peroxisome proliferator, induces pleiotropic responses in liver by activating peroxisome proliferator-activated receptor alpha (PPARalpha), a nuclear receptor. ciprofibrate 0-12 peroxisome proliferator activated receptor alpha Homo sapiens 151-160 15635043-2 2005 The treatment of primary cultured human hepatocytes with a peroxisome proliferator-activated receptor alpha (PPARalpha)-activating concentration of ciprofibrate (10(-) (4) M) increased (HUMAN)SULT2A1 mRNA, immunoreactive protein, and enzymatic activity levels by approximately 2-fold. ciprofibrate 148-160 peroxisome proliferator activated receptor alpha Homo sapiens 59-107 16226225-1 2005 Fibrates such as bezafibrate, gemfibrozil, clofibric acid, ciprofibrate and fenofibrate, are ligands for peroxisome proliferator-activated receptor alpha (PPARalpha), and are used as therapeutic agents in the treatment of hyperlipidemia. ciprofibrate 59-71 peroxisome proliferator activated receptor alpha Homo sapiens 105-153 16226225-1 2005 Fibrates such as bezafibrate, gemfibrozil, clofibric acid, ciprofibrate and fenofibrate, are ligands for peroxisome proliferator-activated receptor alpha (PPARalpha), and are used as therapeutic agents in the treatment of hyperlipidemia. ciprofibrate 59-71 peroxisome proliferator activated receptor alpha Homo sapiens 155-164 15635043-2 2005 The treatment of primary cultured human hepatocytes with a peroxisome proliferator-activated receptor alpha (PPARalpha)-activating concentration of ciprofibrate (10(-) (4) M) increased (HUMAN)SULT2A1 mRNA, immunoreactive protein, and enzymatic activity levels by approximately 2-fold. ciprofibrate 148-160 peroxisome proliferator activated receptor alpha Homo sapiens 109-118 15177943-6 2004 Similar increases in progastrin were seen following treatment with the PPARalpha ligands ciprofibrate and fenofibrate, but not with bezafibrate, gemfibrozil or Wy 14643. ciprofibrate 89-101 peroxisome proliferator activated receptor alpha Homo sapiens 71-80 15100326-3 2004 The PPAR alpha agonists, gemfibrozil, ciprofibrate, and fenofibrate, have an excellent track history as oral agents used to treat hypertriglyceridemia. ciprofibrate 38-50 peroxisome proliferator activated receptor alpha Homo sapiens 4-14 11827749-2 2002 In this study we demonstrate that PPAR-alpha ligands (clofibrate and ciprofibrate) and PPAR-gamma ligands (troglitazone and 15d-prostaglandin J2) inhibit growth and induce monocytic differentiation in HL-60 cells, whereas only PPAR-gamma ligands inhibit growth of U937 cells. ciprofibrate 69-81 peroxisome proliferator activated receptor alpha Homo sapiens 34-44 12055195-6 2002 Constructs containing this element were transactivated by WY14643 and ciprofibrate, ligands of the peroxisome proliferator-activated receptor alpha (PPARalpha), in Caco2 cells. ciprofibrate 70-82 peroxisome proliferator activated receptor alpha Homo sapiens 99-147 12055195-6 2002 Constructs containing this element were transactivated by WY14643 and ciprofibrate, ligands of the peroxisome proliferator-activated receptor alpha (PPARalpha), in Caco2 cells. ciprofibrate 70-82 peroxisome proliferator activated receptor alpha Homo sapiens 149-158 12649303-4 2003 We demonstrated that both PPAR alpha (clofibrate and ciprofibrate) and PPAR gamma ligands (troglitazone and 15 deoxy-prostaglandin J2, 15d-PGJ2) inhibited growth, induced the onset of monocytic-like differentiation, and increased the proportion of G0/G1 cells in the HL-60 leukemic cell line. ciprofibrate 53-65 peroxisome proliferator activated receptor alpha Homo sapiens 26-36 11071880-6 2000 After PPAR alpha activation with ciprofibrate, both mitochondrial and peroxisomal beta-oxidation enzymes were induced, with the strongest response seen in the liver, a moderate response in the kidney, and no significant response in the heart. ciprofibrate 33-45 peroxisome proliferator activated receptor alpha Homo sapiens 6-16 10860941-10 2000 We also provide evidence of the translocation of PPARalpha from the cytosol to the nucleus upon activation by ciprofibrate. ciprofibrate 110-122 peroxisome proliferator activated receptor alpha Homo sapiens 49-58 9512927-6 1997 We have shown that, in the presence of PPAR alpha, the above CYP4A1 construct is transcriptionally activated by a range of structurally different peroxisome proliferators including Wy-14,643, ciprofibrate, clofibric acid and nafenopin. ciprofibrate 192-204 peroxisome proliferator activated receptor alpha Homo sapiens 39-49 9688458-16 1998 In rat and human PPARalpha transactivation assays, the rank order of activation was ciprofibrate > PFOA > oleic acid > or = octanoic acid > octanedioic acid or perfluorooctanol (inactive). ciprofibrate 84-96 peroxisome proliferator activated receptor alpha Homo sapiens 17-26 8567672-8 1996 In transient transfection experiments, the maximum induction of luciferase expression by ciprofibrate and/or 9-cis-retinoic acid is dependent upon cotransfection of expression plasmids for PPAR alpha and RXR alpha. ciprofibrate 89-101 peroxisome proliferator activated receptor alpha Homo sapiens 189-199 25848047-9 2015 In contrast, treatment of fibroblasts with ciprofibrate or WY14643, PPAR-alpha activators, led to peroxisome proliferation and reduced the TGF-beta-induced myofibroblast differentiation and collagen protein in IPF cells. ciprofibrate 43-55 peroxisome proliferator activated receptor alpha Homo sapiens 68-78 21966330-2 2011 Fibrates, including fenofibrate, gemfibrozil, benzafibrate, ciprofibrate, and clofibrate act on PPAR alpha to reduce the level of hypertriglyceridemia. ciprofibrate 60-72 peroxisome proliferator activated receptor alpha Homo sapiens 96-106 18948393-5 2009 Interestingly, sustained activation of PPARalpha by its hypolipidemic ligand, ciprofibrate, abrogates the adaptive fasting response of PPARalpha during prehibernation and overinduces its target genes, disrupting the prehibernation fattening process. ciprofibrate 78-90 peroxisome proliferator activated receptor alpha Homo sapiens 39-48 18948393-5 2009 Interestingly, sustained activation of PPARalpha by its hypolipidemic ligand, ciprofibrate, abrogates the adaptive fasting response of PPARalpha during prehibernation and overinduces its target genes, disrupting the prehibernation fattening process. ciprofibrate 78-90 peroxisome proliferator activated receptor alpha Homo sapiens 135-144