PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19634013-3 2009 N-methyl-N-nitrosourea (MNU), a model S(N)1 methylating agent, induced cell death through a distinct mechanism in two human NSCLC cell lines studied, A549(p53(wt)) and H157(p53(null)). Methylnitrosourea 0-22 tumor protein p53 Homo sapiens 155-158 19634013-3 2009 N-methyl-N-nitrosourea (MNU), a model S(N)1 methylating agent, induced cell death through a distinct mechanism in two human NSCLC cell lines studied, A549(p53(wt)) and H157(p53(null)). Methylnitrosourea 0-22 tumor protein p53 Homo sapiens 173-176 19634013-3 2009 N-methyl-N-nitrosourea (MNU), a model S(N)1 methylating agent, induced cell death through a distinct mechanism in two human NSCLC cell lines studied, A549(p53(wt)) and H157(p53(null)). Methylnitrosourea 24-27 tumor protein p53 Homo sapiens 155-158 19634013-3 2009 N-methyl-N-nitrosourea (MNU), a model S(N)1 methylating agent, induced cell death through a distinct mechanism in two human NSCLC cell lines studied, A549(p53(wt)) and H157(p53(null)). Methylnitrosourea 24-27 tumor protein p53 Homo sapiens 173-176 19634013-4 2009 In A549(p53(wt)), MNU induced G2/M arrest, accompanied by cdc25A degradation, hnRNP B1 induction, hnRNP C1/C2 downregulation. Methylnitrosourea 18-21 tumor protein p53 Homo sapiens 8-11 19634013-6 2009 In H157(p53(null)), MNU induced apoptotic cell death, confirmed by cytofluorometry of DNA content and immunodetection of apoptotic markers, accompanied by overexpression of hnRNP B1 and C1/C2. Methylnitrosourea 20-23 tumor protein p53 Homo sapiens 8-11 10535931-3 1999 Furthermore, treatment of human cells with the S(N)1 DNA methylators N-methyl-N-nitrosourea or N-methyl-N"-nitro-N-nitrosoguanidine results in p53 phosphorylation on serine residues 15 and 392, and these phosphorylation events depend on the presence of functional hMutSalpha and hMutLalpha. Methylnitrosourea 69-91 tumor protein p53 Homo sapiens 143-146 19567395-0 2009 Early modification of c-myc, Ha-ras and p53 expressions by chemical carcinogens (DMBA, MNU). Methylnitrosourea 87-90 tumor protein p53 Homo sapiens 40-43 19567395-4 2009 In the liver, DMBA induced strong onco/suppressor gene expression as early as 6 hours after the treatment, but MNU increased the p53 gene expression 12 hours after the treatment. Methylnitrosourea 111-114 tumor protein p53 Homo sapiens 129-132 19137017-8 2009 In the Mapo1-defective mutant cells treated with MNU, the mitochondrial membrane depolarization and caspase-3 activation were severely suppressed, although phosphorylation of p53, CHK1 and histone H2AX was observed. Methylnitrosourea 49-52 tumor protein p53 Homo sapiens 175-178 19181008-0 2008 Early modification of c-myc, Ha-ras and p53 expressions by N-methyl-N-nitrosourea. Methylnitrosourea 59-81 tumor protein p53 Homo sapiens 40-43 19181008-9 2008 Our findings suggest that MNU has an impact on the expression of c-myc, Ha-ras and p53 genes in 12 hours, especially in bone marrow. Methylnitrosourea 26-29 tumor protein p53 Homo sapiens 83-86 34196654-8 2021 Cell experiments further confirmed that H2 could reverse MNU damage to CECs by decreasing oxidative stress injury, interfering with the NF-kappaB/NLRP3 pathway and the FOXO3a/p53/p21 pathway. Methylnitrosourea 57-60 tumor protein p53 Homo sapiens 175-178 8033110-10 1994 Positive staining with PAb240 or DO7 antibodies against human p53 or with an antibody generated in our laboratory against the hamster p53 fusion protein was observed only in the solid form of well-differentiated ductal adenocarcinoma and in rare cells scattered in 4 of 28 MNU-induced tumors analyzed. Methylnitrosourea 273-276 tumor protein p53 Homo sapiens 134-137 8676917-0 1996 p53 accumulates in micronuclei after treatment with a DNA breaking chemical, methylnitrosourea, and with the spindle poison, vinblastine. Methylnitrosourea 77-94 tumor protein p53 Homo sapiens 0-3