PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19567395-0	2009	Early modification of c-myc, Ha-ras and p53 expressions by chemical carcinogens (DMBA, MNU).	Methylnitrosourea	87-90	tumor protein p53	Homo sapiens	40-43	
19634013-3	2009	N-methyl-N-nitrosourea (MNU), a model S(N)1 methylating agent, induced cell death through a distinct mechanism in two human NSCLC cell lines studied, A549(p53(wt)) and H157(p53(null)).	Methylnitrosourea	0-22	tumor protein p53	Homo sapiens	155-158	
19634013-3	2009	N-methyl-N-nitrosourea (MNU), a model S(N)1 methylating agent, induced cell death through a distinct mechanism in two human NSCLC cell lines studied, A549(p53(wt)) and H157(p53(null)).	Methylnitrosourea	0-22	tumor protein p53	Homo sapiens	173-176	
19634013-3	2009	N-methyl-N-nitrosourea (MNU), a model S(N)1 methylating agent, induced cell death through a distinct mechanism in two human NSCLC cell lines studied, A549(p53(wt)) and H157(p53(null)).	Methylnitrosourea	24-27	tumor protein p53	Homo sapiens	155-158	
19634013-3	2009	N-methyl-N-nitrosourea (MNU), a model S(N)1 methylating agent, induced cell death through a distinct mechanism in two human NSCLC cell lines studied, A549(p53(wt)) and H157(p53(null)).	Methylnitrosourea	24-27	tumor protein p53	Homo sapiens	173-176	
19634013-4	2009	In A549(p53(wt)), MNU induced G2/M arrest, accompanied by cdc25A degradation, hnRNP B1 induction, hnRNP C1/C2 downregulation.	Methylnitrosourea	18-21	tumor protein p53	Homo sapiens	8-11	
19634013-6	2009	In H157(p53(null)), MNU induced apoptotic cell death, confirmed by cytofluorometry of DNA content and immunodetection of apoptotic markers, accompanied by overexpression of hnRNP B1 and C1/C2.	Methylnitrosourea	20-23	tumor protein p53	Homo sapiens	8-11	
19567395-4	2009	In the liver, DMBA induced strong onco/suppressor gene expression as early as 6 hours after the treatment, but MNU increased the p53 gene expression 12 hours after the treatment.	Methylnitrosourea	111-114	tumor protein p53	Homo sapiens	129-132	
19181008-0	2008	Early modification of c-myc, Ha-ras and p53 expressions by N-methyl-N-nitrosourea.	Methylnitrosourea	59-81	tumor protein p53	Homo sapiens	40-43	
19137017-8	2009	In the Mapo1-defective mutant cells treated with MNU, the mitochondrial membrane depolarization and caspase-3 activation were severely suppressed, although phosphorylation of p53, CHK1 and histone H2AX was observed.	Methylnitrosourea	49-52	tumor protein p53	Homo sapiens	175-178	
19181008-9	2008	Our findings suggest that MNU has an impact on the expression of c-myc, Ha-ras and p53 genes in 12 hours, especially in bone marrow.	Methylnitrosourea	26-29	tumor protein p53	Homo sapiens	83-86	
34196654-8	2021	Cell experiments further confirmed that H2 could reverse MNU damage to CECs by decreasing oxidative stress injury, interfering with the NF-kappaB/NLRP3 pathway and the FOXO3a/p53/p21 pathway.	Methylnitrosourea	57-60	tumor protein p53	Homo sapiens	175-178	
10535931-3	1999	Furthermore, treatment of human cells with the S(N)1 DNA methylators N-methyl-N-nitrosourea or N-methyl-N"-nitro-N-nitrosoguanidine results in p53 phosphorylation on serine residues 15 and 392, and these phosphorylation events depend on the presence of functional hMutSalpha and hMutLalpha.	Methylnitrosourea	69-91	tumor protein p53	Homo sapiens	143-146	
8676917-0	1996	p53 accumulates in micronuclei after treatment with a DNA breaking chemical, methylnitrosourea, and with the spindle poison, vinblastine.	Methylnitrosourea	77-94	tumor protein p53	Homo sapiens	0-3	
8033110-10	1994	Positive staining with PAb240 or DO7 antibodies against human p53 or with an antibody generated in our laboratory against the hamster p53 fusion protein was observed only in the solid form of well-differentiated ductal adenocarcinoma and in rare cells scattered in 4 of 28 MNU-induced tumors analyzed.	Methylnitrosourea	273-276	tumor protein p53	Homo sapiens	134-137