PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15870882-1	2005	The aim of this study was to assess whether combined evaluation of O6-methylguanine methyltransferase (MGMT) and hMLH1 status determines sensitivity to monofuntional alkylating agents such as N-methyl-N-nitrosourea (MNU) and dacarbazine (DTIC) against gallbladder carcinoma cells.	Methylnitrosourea	192-214	mutL homolog 1	Homo sapiens	113-118	
31955481-3	2020	Immunoprecipitation analyses showed that FAN1 interacted with both MLH1 and MSH2 after treatment with N-methyl-N-nitrosourea (MNU), indicating the formation of a FAN1-MMR complex.	Methylnitrosourea	102-124	mutL homolog 1	Homo sapiens	67-71	
31955481-3	2020	Immunoprecipitation analyses showed that FAN1 interacted with both MLH1 and MSH2 after treatment with N-methyl-N-nitrosourea (MNU), indicating the formation of a FAN1-MMR complex.	Methylnitrosourea	126-129	mutL homolog 1	Homo sapiens	67-71	
9233776-6	1997	Furthermore, cisplatin and doxorubicin-resistant ovarian lines deficient in hMLH1 expression are cross-resistant to 6-thioguanine and the methylating agent N-methyl-N-nitrosourea (MNU).	Methylnitrosourea	156-178	mutL homolog 1	Homo sapiens	76-81	
9233776-6	1997	Furthermore, cisplatin and doxorubicin-resistant ovarian lines deficient in hMLH1 expression are cross-resistant to 6-thioguanine and the methylating agent N-methyl-N-nitrosourea (MNU).	Methylnitrosourea	180-183	mutL homolog 1	Homo sapiens	76-81	
22209521-7	2012	After MNU exposure, phosphorylation of AMPKalpha occurred in an MLH1-dependent manner, and this activation of AMPK was not observed in cells in which the expression of either the Mapo1 or the Flcn gene was downregulated.	Methylnitrosourea	6-9	mutL homolog 1	Homo sapiens	64-68	
15870882-5	2005	As a result, cell lines that were MGMT-/hMLH1+ had the highest sensitivity to MNU, compared with MGMT+/hMLH1+ and MGMT-/hMLH1- cells.	Methylnitrosourea	78-81	mutL homolog 1	Homo sapiens	40-45	
15870882-6	2005	In flow cytometric analysis, G2-M cell cycle arrest was specifically observed in GB-d1 cells with MGMT-/hMLH1+ and expression of cyclin A and Cdc2 in GB-d1 cells was significantly reduced by MNU treatment, but not observed in KMG-C cells with MGMT+/hMLH1+.	Methylnitrosourea	191-194	mutL homolog 1	Homo sapiens	104-109	
15870882-6	2005	In flow cytometric analysis, G2-M cell cycle arrest was specifically observed in GB-d1 cells with MGMT-/hMLH1+ and expression of cyclin A and Cdc2 in GB-d1 cells was significantly reduced by MNU treatment, but not observed in KMG-C cells with MGMT+/hMLH1+.	Methylnitrosourea	191-194	mutL homolog 1	Homo sapiens	249-254	
15870882-9	2005	In conclusion, MNU suppressed cell proliferation of MGMT-/hMLH1+ gallbladder carcinoma cells by arresting the cell cycle at the G2-M phase, accompanied by down-regulation of cyclin A and Cdc2.	Methylnitrosourea	15-18	mutL homolog 1	Homo sapiens	58-63