PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20732338-11	2011	Hormone treatment sustained the growth of the lesions induced by MNU by increasing expression of Areg, Bcl-2, Ccnd-1 and Vegf genes, while decreasing expression of Bad, Bax, Casp 3, 8, 9 and p53 genes.	Methylnitrosourea	65-68	BCL2 associated X, apoptosis regulator	Rattus norvegicus	169-172	
28786001-8	2017	Two days after first MNU administration, some genes associated with apoptosis were altered in the mammary tissue from the TCDD group (Bax and Caspase 3 down- and Bcl-2 upregulated) but were also partially reestablished by maternal Res.	Methylnitrosourea	21-24	BCL2 associated X, apoptosis regulator	Rattus norvegicus	134-137	
16047940-7	2005	Extensive investigation in the rats revealed that MNU-induced photoreceptor cell loss was due to apoptosis with a decrease of Bcl-2 protein, increase of Bax protein, and activation of caspase families.	Methylnitrosourea	50-53	BCL2 associated X, apoptosis regulator	Rattus norvegicus	153-156	
20003911-8	2010	RT-PCR analysis demonstrated that transcription levels of Bax, Bcl-xl and Caspase-3 in MNU control group and GSL treatment group were all upregulated on 1 d (p < 0.01) and peaked on 3 d (p < 0.01) after MNU injection compared to before MNU injection.	Methylnitrosourea	87-90	BCL2 associated X, apoptosis regulator	Rattus norvegicus	58-61	
20003911-8	2010	RT-PCR analysis demonstrated that transcription levels of Bax, Bcl-xl and Caspase-3 in MNU control group and GSL treatment group were all upregulated on 1 d (p < 0.01) and peaked on 3 d (p < 0.01) after MNU injection compared to before MNU injection.	Methylnitrosourea	209-212	BCL2 associated X, apoptosis regulator	Rattus norvegicus	58-61	
20003911-8	2010	RT-PCR analysis demonstrated that transcription levels of Bax, Bcl-xl and Caspase-3 in MNU control group and GSL treatment group were all upregulated on 1 d (p < 0.01) and peaked on 3 d (p < 0.01) after MNU injection compared to before MNU injection.	Methylnitrosourea	209-212	BCL2 associated X, apoptosis regulator	Rattus norvegicus	58-61	
20003911-11	2010	Expression ratios of Bax/Bcl-xl were raised after MNU injection on 1 and 3 d vs. 0 h before MNU (both p < 0.01), peaked on 3 d, then dropped after GSL treatment on 1, 3, 7 and 10 d vs. MNU group (all p < 0.01).	Methylnitrosourea	50-53	BCL2 associated X, apoptosis regulator	Rattus norvegicus	21-24	
20003911-11	2010	Expression ratios of Bax/Bcl-xl were raised after MNU injection on 1 and 3 d vs. 0 h before MNU (both p < 0.01), peaked on 3 d, then dropped after GSL treatment on 1, 3, 7 and 10 d vs. MNU group (all p < 0.01).	Methylnitrosourea	92-95	BCL2 associated X, apoptosis regulator	Rattus norvegicus	21-24	
20003911-11	2010	Expression ratios of Bax/Bcl-xl were raised after MNU injection on 1 and 3 d vs. 0 h before MNU (both p < 0.01), peaked on 3 d, then dropped after GSL treatment on 1, 3, 7 and 10 d vs. MNU group (all p < 0.01).	Methylnitrosourea	92-95	BCL2 associated X, apoptosis regulator	Rattus norvegicus	21-24	
16168987-4	2006	During 7 days after the intraperitoneal injection of MNU (60 mg/kg), rat retinas exhibited DNA fragmentation characteristic of apoptosis and activation of PARP, phosphorylation of JNK and c-Jun, induction of AP-1 (c-Jun and c-Fos) and Bax, as well as photoreceptor cell loss.	Methylnitrosourea	53-56	BCL2 associated X, apoptosis regulator	Rattus norvegicus	235-238	
18788994-8	2008	As compared with the MNU-treated group, MaFGF significantly upregulated the expression of Bcl-2 mRNA and protein and downregulated the expression of Bax mRNA and protein (P = <0.001).	Methylnitrosourea	21-24	BCL2 associated X, apoptosis regulator	Rattus norvegicus	149-152	
10576206-5	1999	Therefore MNU-induced photoreceptor cell death was attributed to DNA adduct formation restricted to photoreceptor cell nuclei leading to photoreceptor cell apoptosis by up-regulation of Bax protein, down-modulation of Bcl-2 protein, and activation of caspases 3, 6, and 8.	Methylnitrosourea	10-13	BCL2 associated X, apoptosis regulator	Rattus norvegicus	186-189	
10930042-6	2000	In the apoptosis cascade, upregulation of Bax, downregulation of Bcl-2, and increased CPP32 protease (caspase-3) activity were seen 12 hours after MNU dosing.	Methylnitrosourea	147-150	BCL2 associated X, apoptosis regulator	Rattus norvegicus	42-45	
10930042-7	2000	Therefore, the pathogenesis of MNU-induced cataract was associated with DNA adduct formation in the lens epithelial cell nuclei leading to apoptosis by upregulation of Bax protein, downmodulation of Bcl-2 protein, and activation of caspase-3.	Methylnitrosourea	31-34	BCL2 associated X, apoptosis regulator	Rattus norvegicus	168-171