PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24194395-6 2014 Pretreatment of the HepG2 cells with caspase-3, caspase-8, and caspase-9 inhibitors partially but significantly reduced the release of lactate dehydrogenase, indicating that sertraline-induced apoptosis is mediated by both intrinsic and extrinsic apoptotic pathways. Sertraline 174-184 caspase 8 Homo sapiens 48-57 32626921-8 2020 Overall, sertraline enhanced TRAIL-mediated apoptosis via the downregulation of AMP-activated protein kinase phosphorylation, resulting in the inhibition of autophagic flux, upregulation of DR5 expression, and activation of the apoptotic caspase cascade. Sertraline 9-19 caspase 8 Homo sapiens 238-245