PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21658928-0 2012 Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. alpha-Linolenic Acid 0-20 stearoyl-CoA desaturase Homo sapiens 97-122 21658928-5 2012 This study investigated the mechanisms by which ALA regulated SCD1 and subsequent effect on cholesterol storage and transport in MDFCs. alpha-Linolenic Acid 48-51 stearoyl-CoA desaturase Homo sapiens 62-66 21658928-7 2012 Alpha-linolenic acid treatment and SCD1 siRNA significantly decreased SCD1 expression in MDFCs. alpha-Linolenic Acid 0-20 stearoyl-CoA desaturase Homo sapiens 70-74 21658928-9 2012 Alpha-linolenic acid activated the nuclear receptor farnesoid-X-receptor, which in turn increased its target gene small heterodimer partner (SHP) expression, and decreased liver-X-receptor dependent sterol regulatory element binding protein 1c transcription, ultimately resulting in repressed SCD1 expression. alpha-Linolenic Acid 0-20 stearoyl-CoA desaturase Homo sapiens 293-297 21658928-10 2012 In conclusion, repression of SCD1 by ALA favorably increased cholesterol efflux and decreased cholesterol accumulation in foam cells. alpha-Linolenic Acid 37-40 stearoyl-CoA desaturase Homo sapiens 29-33 21871057-9 2011 Alpha-linolenic acid (ALA), the major n-3 polyunsaturated fatty acids found in walnuts, recaptured SCD1 reduction in MDFC, a mechanism mediated through activation of nuclear receptor farnesoid-X-receptor (FXR). alpha-Linolenic Acid 0-20 stearoyl-CoA desaturase Homo sapiens 99-103 21871057-9 2011 Alpha-linolenic acid (ALA), the major n-3 polyunsaturated fatty acids found in walnuts, recaptured SCD1 reduction in MDFC, a mechanism mediated through activation of nuclear receptor farnesoid-X-receptor (FXR). alpha-Linolenic Acid 22-25 stearoyl-CoA desaturase Homo sapiens 99-103 21291825-5 2009 Effects of linoleic acid (LA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA) on mRNA levels of SCD, fatty acid elongases 5 and 6 (Elovl5 and Elovl6), fatty acid synthase, carnitine palmitoyltransferase-1, and sterol response element binding protein-1c were investigated in Hep G2 cells after 24-hour incubations. alpha-Linolenic Acid 31-51 stearoyl-CoA desaturase Homo sapiens 109-112 21291825-5 2009 Effects of linoleic acid (LA), alpha-linolenic acid (ALA), and eicosapentaenoic acid (EPA) on mRNA levels of SCD, fatty acid elongases 5 and 6 (Elovl5 and Elovl6), fatty acid synthase, carnitine palmitoyltransferase-1, and sterol response element binding protein-1c were investigated in Hep G2 cells after 24-hour incubations. alpha-Linolenic Acid 53-56 stearoyl-CoA desaturase Homo sapiens 109-112 21291825-12 2009 CONCLUSIONS: Diets enriched in LA, ALA, and by metabolic inference EPA, can regulate SCD activity at the level of transcription, a nutritional intervention that may be useful in the management of increased levels of serum triglycerides in cardiometabolic disorders. alpha-Linolenic Acid 35-38 stearoyl-CoA desaturase Homo sapiens 85-88 32725293-1 2021 PURPOSE: Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and alpha-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. alpha-Linolenic Acid 117-137 stearoyl-CoA desaturase Homo sapiens 171-192 32725293-1 2021 PURPOSE: Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and alpha-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. alpha-Linolenic Acid 117-137 stearoyl-CoA desaturase Homo sapiens 194-198 32725293-1 2021 PURPOSE: Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and alpha-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. alpha-Linolenic Acid 139-142 stearoyl-CoA desaturase Homo sapiens 171-192 32725293-1 2021 PURPOSE: Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and alpha-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. alpha-Linolenic Acid 139-142 stearoyl-CoA desaturase Homo sapiens 194-198 33526157-3 2021 The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and alpha-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). alpha-Linolenic Acid 173-193 stearoyl-CoA desaturase Homo sapiens 28-32 33526157-3 2021 The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and alpha-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). alpha-Linolenic Acid 195-198 stearoyl-CoA desaturase Homo sapiens 28-32 33298236-2 2020 In the context of de novo omega-3 (n-3) PUFA biosynthesis, it was thought that most animals lack the fatty acid (FA) desaturase enzymes that convert stearic acid (18:0) into alpha-linolenic acid (ALA; 18:3n-3), the main FA precursor for n-3 long-chain PUFA. alpha-Linolenic Acid 174-194 stearoyl-CoA desaturase Homo sapiens 101-127 33298236-2 2020 In the context of de novo omega-3 (n-3) PUFA biosynthesis, it was thought that most animals lack the fatty acid (FA) desaturase enzymes that convert stearic acid (18:0) into alpha-linolenic acid (ALA; 18:3n-3), the main FA precursor for n-3 long-chain PUFA. alpha-Linolenic Acid 196-199 stearoyl-CoA desaturase Homo sapiens 101-127 31943072-2 2020 The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and alpha-linolenic acid. alpha-Linolenic Acid 250-270 stearoyl-CoA desaturase Homo sapiens 4-25 31943072-2 2020 The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and alpha-linolenic acid. alpha-Linolenic Acid 250-270 stearoyl-CoA desaturase Homo sapiens 27-31 31943072-2 2020 The fatty acid desaturase (FADS) genes also influence PUFA status, with the FADS genes controlling how much product (eg, arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) is metabolized from the precursor molecules linoleic acid and alpha-linolenic acid. alpha-Linolenic Acid 250-270 stearoyl-CoA desaturase Homo sapiens 76-80 29080057-8 2017 Fatty acid desaturase (FADS) pathway activity (estimated using the ratio of eicosapentaenoic acid/alpha-linolenic acid) was higher in men (p < 0.01). alpha-Linolenic Acid 98-118 stearoyl-CoA desaturase Homo sapiens 0-21 27527582-4 2017 In general, carriers of FADS minor alleles tend to have higher habitual plasma and tissue levels of LA and alphaLNA, and lower levels of arachidonic acid, EPA and also to a lesser extent DHA. alpha-Linolenic Acid 107-115 stearoyl-CoA desaturase Homo sapiens 24-28