PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17279482-6	2007	Among them, tanshinone IIA and cryptotanshinone are found to be potent inhibitors to CYP1A2, while artemisinin is a marginal inhibitor to CYP1A2 and glycyrrhetic acid is a weak inhibitor to CYP2C9.	Glycyrrhetinic Acid	149-166	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	190-196	
22943175-9	2012	The inhibitory action of glycyrrhetinic acid was observed in CYP2C9 for 4-hydroxylation of diclofenac, CYP2C19 for 4"-hydroxylation of (S)-mephenytoin and CYP3A4 for 1"-hydroxylation of midazolam with half maximal inhibitory concentration (IC50) values of 4.3-fold, 3.8-fold and 9.6-fold higher than specific inhibitors in HLM, respectively.	Glycyrrhetinic Acid	25-44	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	61-67	
26712778-2	2015	This study evaluated the effect of GA on the activity of five P450(CYP450) cytochrome enzymes: CYP2A6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4, in human liver microsomes (HLMs) and recombinant cDNA-expressed enzyme systems using a HPLC-MS/MS CYP-specific probe substrate assay.	Glycyrrhetinic Acid	35-37	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-109	
26712778-6	2015	Moreover, CYP2C9 and CYP2C19 could also be inhibited significantly by GA with IC50 of 42.89 and 40.26 muM in HLMs, respectively.	Glycyrrhetinic Acid	70-72	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	10-16	
22943175-12	2012	The results suggest that glycyrrhetinic acid has the potential to interact with a wide range of xenobiotics or endogenous chemicals that are CYP2C9, CYP2C19 and CYP3A4 substrates.	Glycyrrhetinic Acid	25-44	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	141-147	
21462897-6	2011	At concentration up to 50 micromol x L(-1), GA inhibited CYP2C19, CYP2C9 and CYP3A4 enzyme activities with the inhibitory potencies up to 50%.	Glycyrrhetinic Acid	44-46	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	66-72