PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20045987-7 2009 Both imipramine (typical substrate of UGT1A3 and 1A4) and flurbiprofen (typical substrate of UGT2B7) inhibit the glucuronidation of glycyrrhetinic acid. Glycyrrhetinic Acid 132-151 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 93-99 23148031-3 2013 Furthermore, the inhibition kinetic type and parameters were determined for the inhibition of glycyrrhetinic acid towards UGT1A3 and UGT2B7. Glycyrrhetinic Acid 94-113 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 133-139 23148031-4 2013 Data fitting using Dixon and Lineweaver-Burk plots demonstrated that the inhibition of UGT1A3 and UGT2B7 by glycyrrhetinic acid was best fit to competitive and noncompetitive type, respectively. Glycyrrhetinic Acid 108-127 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 98-104 23148031-5 2013 The second plot using the slopes from Lineweaver-Burk plots versus glycyrrhetinic acid concentrations was employed to calculate the inhibition kinetic parameters (K(i)), and the values were calculated to be 0.2 and 1.7 muM for UGT1A3 and UGT2B7, respectively. Glycyrrhetinic Acid 67-86 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 238-244