PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25463381-3	2014	Since the major metabolite of GL, glycyrrhetic acid (GA), is largely responsible for pseudoaldosteronism via inhibition of the kidney enzyme 11beta-hydroxysteroiddehydrogenase 2 (11beta-HSD 2), a semi-PBPK model was first developed in rat to predict the systemic pharmacokinetics of and the kidney exposure to GA. A human PBPK model was then developed using parameters either from the rat model or from in vitro studies in combination with essential scaling factors.	Glycyrrhetinic Acid	34-51	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	186-191	
22543032-3	2012	In this study we compared the inhibitory effects of GA, GL, and 3-monoglucuronyl-glycyrrhetinic acid (3MGA), another metabolite of GL, on 11beta-HSD2 activity by using microsomes and rat kidney tissue slices.	Glycyrrhetinic Acid	52-54	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	138-149	
22543032-4	2012	GA, 3MGA, and GL inhibited 11beta-HSD2 in rat kidney microsomes, with IC(50) values of 0.32, 0.26, and 2.2 muM, respectively.	Glycyrrhetinic Acid	0-2	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	27-38	
18362159-2	2008	It is thought to induce pseudoaldosteronism via inhibition of type 2 11beta-hydroxysteroid dehydrogenase (11beta-HSD2) by glycyrrhetinic acid (GA), a major metabolite of GL.	Glycyrrhetinic Acid	122-141	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	106-117	
18362159-2	2008	It is thought to induce pseudoaldosteronism via inhibition of type 2 11beta-hydroxysteroid dehydrogenase (11beta-HSD2) by glycyrrhetinic acid (GA), a major metabolite of GL.	Glycyrrhetinic Acid	143-145	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	106-117	
22543032-7	2012	When GA (100 mg/kg/day) was administered orally for 16 days to Eisai hyperbilirubinemic rats, plasma concentrations and urinary excretion of 3MGA were significantly higher, whereas the activity of 11beta-HSD2 in kidney microsomes was significantly lower compared with Sprague Dawley rats.	Glycyrrhetinic Acid	5-7	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	197-208	
25463381-3	2014	Since the major metabolite of GL, glycyrrhetic acid (GA), is largely responsible for pseudoaldosteronism via inhibition of the kidney enzyme 11beta-hydroxysteroiddehydrogenase 2 (11beta-HSD 2), a semi-PBPK model was first developed in rat to predict the systemic pharmacokinetics of and the kidney exposure to GA. A human PBPK model was then developed using parameters either from the rat model or from in vitro studies in combination with essential scaling factors.	Glycyrrhetinic Acid	53-55	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	186-191