PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20418897-0	2010	Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-kappaB pathways in TNF-alpha-activated endothelial cells.	Glycyrrhetinic Acid	0-19	mitogen-activated protein kinase 8	Homo sapiens	60-63	
20418897-7	2010	GA selectively inhibited TNF-alpha-activated signal pathway of c-Jun N-terminal kinase (JNK), without affecting extracellular signal-regulated kinase 1/2 and p38.	Glycyrrhetinic Acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	63-86	
20418897-7	2010	GA selectively inhibited TNF-alpha-activated signal pathway of c-Jun N-terminal kinase (JNK), without affecting extracellular signal-regulated kinase 1/2 and p38.	Glycyrrhetinic Acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	88-91	
20418897-9	2010	Finally, pretreatment with GA or the inhibitors of NF-kappaB, JNK, and p38 reduced the ICAM-1 protein expression induced by TNF-alpha.	Glycyrrhetinic Acid	27-29	mitogen-activated protein kinase 8	Homo sapiens	62-65	
20418897-11	2010	This inhibition is attributed to GA interruption of both JNK/c-Jun and I kappaB/NF-kappaB signaling pathways, which decrease activator protein-1 (AP-1) and NF-kappaB mediated ICAM-1 expressions.	Glycyrrhetinic Acid	33-35	mitogen-activated protein kinase 8	Homo sapiens	57-60	
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Glycyrrhetinic Acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	96-119	
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Glycyrrhetinic Acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	121-124	
30871060-9	2019	GA also inhibited the PMA-induced phosphorylation of IkappaB kinase alpha/beta (IKKalpha/beta), c-Jun N-terminal kinase (JNK) and p38 proteins (P38), suggesting that IKKalpha/beta, JNK and P38 activation is dependent on PKC activity.	Glycyrrhetinic Acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	181-184	
26549806-5	2015	The c-jun N-terminal kinase (JNK) pathway was activated after incubation with GA. Pretreatment with the JNK inhibitor SP600125 or silencing of the JNK pathway by siRNA of JNK or c-jun decreased GA-induced autophagy.	Glycyrrhetinic Acid	78-80	mitogen-activated protein kinase 8	Homo sapiens	4-27	
26549806-5	2015	The c-jun N-terminal kinase (JNK) pathway was activated after incubation with GA. Pretreatment with the JNK inhibitor SP600125 or silencing of the JNK pathway by siRNA of JNK or c-jun decreased GA-induced autophagy.	Glycyrrhetinic Acid	78-80	mitogen-activated protein kinase 8	Homo sapiens	29-32	
26549806-5	2015	The c-jun N-terminal kinase (JNK) pathway was activated after incubation with GA. Pretreatment with the JNK inhibitor SP600125 or silencing of the JNK pathway by siRNA of JNK or c-jun decreased GA-induced autophagy.	Glycyrrhetinic Acid	78-80	mitogen-activated protein kinase 8	Homo sapiens	104-107	
26549806-5	2015	The c-jun N-terminal kinase (JNK) pathway was activated after incubation with GA. Pretreatment with the JNK inhibitor SP600125 or silencing of the JNK pathway by siRNA of JNK or c-jun decreased GA-induced autophagy.	Glycyrrhetinic Acid	78-80	mitogen-activated protein kinase 8	Homo sapiens	104-107	
26549806-5	2015	The c-jun N-terminal kinase (JNK) pathway was activated after incubation with GA. Pretreatment with the JNK inhibitor SP600125 or silencing of the JNK pathway by siRNA of JNK or c-jun decreased GA-induced autophagy.	Glycyrrhetinic Acid	78-80	mitogen-activated protein kinase 8	Homo sapiens	104-107	
26549806-7	2015	The GA-induced JNK pathway activation and autophagy were decreased by IRE1alpha knockdown, and inhibition of autophagy or the JNK cascade increased GA-stimulated IRE1alpha expression.	Glycyrrhetinic Acid	4-6	mitogen-activated protein kinase 8	Homo sapiens	15-18	
26549806-7	2015	The GA-induced JNK pathway activation and autophagy were decreased by IRE1alpha knockdown, and inhibition of autophagy or the JNK cascade increased GA-stimulated IRE1alpha expression.	Glycyrrhetinic Acid	148-150	mitogen-activated protein kinase 8	Homo sapiens	126-129	
26549806-8	2015	In addition, GA-induced cell proliferative inhibition and apoptosis were increased by inhibition of autophagy or the JNK pathway.	Glycyrrhetinic Acid	13-15	mitogen-activated protein kinase 8	Homo sapiens	117-120	
26549806-9	2015	Our study was the first to demonstrate that GA induces cytoprotective autophagy in non-small cell lung cancer cells by activating the IRE1alpha-JNK/c-jun pathway.	Glycyrrhetinic Acid	44-46	mitogen-activated protein kinase 8	Homo sapiens	144-147	
24461294-8	2014	Overall, our findings suggest that GA induces apoptosis via inhibition of PKC alpha/betaII and activation of JNK in NCI-H460 non-small lung cancer cells as a potent anticancer candidate for lung cancer treatment.	Glycyrrhetinic Acid	35-37	mitogen-activated protein kinase 8	Homo sapiens	109-112