PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32261169-1 2013 Acid-degradable cationic polyrotaxanes (PRXs) composed of N,N-dimethylaminoethyl (DMAE) group-modified alpha-cyclodextrins (CDs) that were threaded onto a poly(ethylene glycol) capped with a bulky stopper via acid-cleavable 3-sulfanylpropionyl ester linkages (DMAE-COO-PRX) were developed for improving the cytoplasmic transportation of PRX/siRNA polyplexes. alpha-Cyclodextrins 103-122 periaxin Homo sapiens 40-43 32261169-1 2013 Acid-degradable cationic polyrotaxanes (PRXs) composed of N,N-dimethylaminoethyl (DMAE) group-modified alpha-cyclodextrins (CDs) that were threaded onto a poly(ethylene glycol) capped with a bulky stopper via acid-cleavable 3-sulfanylpropionyl ester linkages (DMAE-COO-PRX) were developed for improving the cytoplasmic transportation of PRX/siRNA polyplexes. alpha-Cyclodextrins 124-127 periaxin Homo sapiens 40-43 23332177-1 2013 To achieve successful delivery of siRNA therapeutics, cytocleavable cationic polyrotaxanes (PRXs) composed of N,N-dimethylaminoethyl (DMAE) group-modified alpha-cyclodextrins (CDs) that were threaded onto a poly(ethylene glycol) (PEG) axis and capped with a bulky stopper using cytocleavable disulfide linkages (DMAE-PRX) were utilized as an siRNA carrier. alpha-Cyclodextrins 155-174 periaxin Homo sapiens 92-95 23332177-4 2013 Additionally, the DMAE-PRXs with 52 threading CDs (52CD-PRXs) showed greater binding capabilities with siRNA and greater resistance to polyanion competition than 31CD-PRXs, indicating that the highly CD-threaded PRX structure in the 52CD-PRXs is superior in forming stable polyplexes with siRNA. alpha-Cyclodextrins 46-49 periaxin Homo sapiens 23-26