PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24742766-2 2014 For the past decade, most of these efforts have focused on the hyperpolarization-activated cyclic nucleotide gated-(HCN) gene family of channels alone or in combination with other genes. Nucleotides, Cyclic 91-108 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 116-119 15003173-1 2004 Hyperpolarization-activated HCN channels are modulated by direct binding of cyclic nucleotides. Nucleotides, Cyclic 76-94 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 28-31 24983358-1 2014 Hyperpolarization-activated cyclic nucleotide-regulated HCN channels underlie the Na+-K+ permeable IH pacemaker current. Nucleotides, Cyclic 28-45 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 56-59 18367452-1 2008 Activation of cyclic nucleotide-modulated channels such as CNG and HCN channels is promoted by ligand-induced conformational changes in their C-terminal regions. Nucleotides, Cyclic 14-31 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 67-70 16045997-3 2005 We discuss studies where antibodies modulate functions of voltage gated sodium, voltage gated potassium, voltage gated calcium hyperpolarisation activated cyclic nucleotide (HCN gated) and transient receptor potential (TRP) channels. Nucleotides, Cyclic 155-172 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 174-177 15951376-1 2005 HCN channels are activated by membrane hyperpolarization and regulated by cyclic nucleotides, such as cyclic adenosine-mono-phosphate (cAMP). Nucleotides, Cyclic 74-92 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 0-3 15923185-9 2005 A negative shift of V0.5 induced by cyclic nucleotides is an unprecedented feature within the HCN channel family. Nucleotides, Cyclic 36-54 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 94-97 19553449-5 2009 Previously, we identified putative pacemaker neurons expressing parvalbumin (PV) and/or the pacemaker hyperpolarization-activated and cyclic nucleotide-gated nonselective cation channel (HCN) in the MS. Nucleotides, Cyclic 134-151 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 187-190 18565991-3 2008 In recent studies the hyperpolarization-activated, cyclic nucleotide-gated non-selective cation (HCN) channel was shown to participate in theta synchronization of the medial septum. Nucleotides, Cyclic 51-68 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 97-100 18252758-1 2008 AIMS: The hyperpolarization-activated cyclic nucleotide-gated (HCN) current I(f)/I(HCN) is generally thought to be carried by Na(+) and K(+) under physiological conditions. Nucleotides, Cyclic 38-55 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 63-66 18252758-1 2008 AIMS: The hyperpolarization-activated cyclic nucleotide-gated (HCN) current I(f)/I(HCN) is generally thought to be carried by Na(+) and K(+) under physiological conditions. Nucleotides, Cyclic 38-55 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 83-86 18270171-3 2008 Here we show that open HCN channels (the hyperpolarization-activated, cyclic nucleotide sensitive pore forming subunits of I(H)) undergo a fast, voltage-dependent block by intracellular Mg in a manner that suggests the ion binds close to, or within, the selectivity filter. Nucleotides, Cyclic 70-87 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 23-26 17569731-1 2007 Activation of native IH pacemaker channels and channels formed on heterologous expression of some isoforms of their pore forming HCN (hyperpolarization-activated, cyclic nucleotide-regulated) subunits is inhibited by the intravenous general anaesthetic propofol (2,6-diisopropylphenol). Nucleotides, Cyclic 163-180 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 129-132 17562313-0 2007 Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacy. Nucleotides, Cyclic 26-44 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 10-13 16870744-1 2006 Hyperpolarization-activated cyclic nucleotide-gated ion channels (h-channels; I(h); HCN) modulate intrinsic excitability in hippocampal and neocortical pyramidal neurons, among others. Nucleotides, Cyclic 28-45 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 84-87 16818216-3 2006 OBJECTIVE: The purpose of this study was to investigate the electrophysiological consequences of two approaches used to create a biological pacemaker: overexpression of the hyperpolarization-activated cyclic nucleotide gated channel (HCN "pacemaker" channels) and suppression of the inward-rectifier potassium current, I(K1). Nucleotides, Cyclic 201-218 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 234-237 15572113-1 2004 Cyclic nucleotides directly enhance the opening of the tetrameric CNG and HCN channels, although the mechanism remains unclear. Nucleotides, Cyclic 0-18 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 74-77 12351622-1 2002 Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels underlie spontaneous rhythmic activities in the heart and brain. Nucleotides, Cyclic 29-46 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 54-57 10414361-3 1999 By comparing the sequences of HCN channels to other members of the K channel superfamily, we discuss how channel opening may be coupled to membrane hyperpolarization and to direct binding of cyclic nucleotide. Nucleotides, Cyclic 191-208 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 30-33 10430953-1 1999 Rhythmic activity of neurons and heart cells is endowed by pacemaker channels that are activated by hyperpolarization and directly regulated by cyclic nucleotides (termed HCN channels). Nucleotides, Cyclic 144-162 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 171-174 33082475-1 2020 Voltage-gated potassium channels (Kv) and cyclic nucleotide-binding domain-containing cation channels HCN, CNG, and KCNH are the evolutionarily related families of ion channels in animals. Nucleotides, Cyclic 42-59 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 102-105 34458814-2 2021 Alteration of basal levels of cAMP is known to activate protein kinases, regulate phosphodiesterases and modulate the activity of ion channels such as Hyper polarization-activated cyclic nucleotide gated channels (HCN). Nucleotides, Cyclic 180-197 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 214-217 34458814-10 2021 Thus, combining these advanced non-invasive paradigms, we report a cAMP dependent ensemble and single particle behavior of HCN channels mediated by its cyclic nucleotide binding domain, opening innovative ways to dissect biochemical pathways at the nanoscale and real-time in living cells. Nucleotides, Cyclic 152-169 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 123-126 35106839-1 2022 Whether or not the hyperpolarization-activated cyclic nucleotide-gated nonselective cation channel (HCN or funny current If ) is involved in pacemaking - recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. Nucleotides, Cyclic 47-64 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 100-103 32633755-4 2020 TRIP8b controls HCN gating by interacting with the cyclic nucleotide-binding domain (CNBD) and competing for cAMP binding. Nucleotides, Cyclic 51-68 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 16-19 32267232-5 2020 Further, we demonstrate the utility of DISC algorithm to probe cooperativity between multiple binding events in the cyclic nucleotide binding domains of HCN pacemaker channel. Nucleotides, Cyclic 116-133 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 153-156 31601020-0 2019 Novel Potassium Channels in Kidney Mitochondria: The Hyperpolarization-Activated and Cyclic Nucleotide-Gated HCN Channels. Nucleotides, Cyclic 85-102 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 109-112 31130235-0 2019 Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function. Nucleotides, Cyclic 18-35 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 65-68 29971015-0 2018 Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility. Nucleotides, Cyclic 28-45 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 67-70 29971015-1 2018 Purpose: Hyperpolarization-activated cyclic nucleotide gated non-selective (HCN) channels have been demonstrated in the urinary bladder in various species. Nucleotides, Cyclic 37-54 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 76-79