PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22218461-9 2012 Tri-DAP and MDP led to the production of IL-6 and IL-8 and the activation of NF-kappaB and MAPK in PDL cells. Acetylmuramyl-Alanyl-Isoglutamine 24-27 interleukin 6 Homo sapiens 53-57 19783680-11 2009 Costimulation of monocytes with LPS and muramyl dipeptide induced an enhanced IL-6 response that was suppressed by siMAIL. Acetylmuramyl-Alanyl-Isoglutamine 40-57 interleukin 6 Homo sapiens 78-82 19236332-6 2009 Therefore, cell-wall components of bacteria (lipopolysaccharide, muramyl dipeptide, diamino pimelic acid) stimulate IL-6 production in normal and tumoral pituitary. Acetylmuramyl-Alanyl-Isoglutamine 65-82 interleukin 6 Homo sapiens 116-120 16414084-0 2006 Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Acetylmuramyl-Alanyl-Isoglutamine 87-104 interleukin 6 Homo sapiens 57-61 16414084-7 2006 Functional responses were assessed by measuring IL-6 release from endothelial cells treated with muramyl dipeptide (MDP), synthetic lipopeptide (Pam3CSK4) and lipopolysaccharide (LPS). Acetylmuramyl-Alanyl-Isoglutamine 97-114 interleukin 6 Homo sapiens 48-52 16414084-7 2006 Functional responses were assessed by measuring IL-6 release from endothelial cells treated with muramyl dipeptide (MDP), synthetic lipopeptide (Pam3CSK4) and lipopolysaccharide (LPS). Acetylmuramyl-Alanyl-Isoglutamine 116-119 interleukin 6 Homo sapiens 48-52 11531018-4 2001 Co-administration of PepG (10 microg/mL) or muramyl dipeptide (MDP, 1 microg/mL) with LPS (10 ng/mL) caused significantly elevated values of TNF-alpha and IL-6 in the blood that could not be obtained by the sum of the values obtained by each stimulant alone, or by 3-fold higher doses of either bacterial component alone. Acetylmuramyl-Alanyl-Isoglutamine 44-61 interleukin 6 Homo sapiens 155-159 11531018-4 2001 Co-administration of PepG (10 microg/mL) or muramyl dipeptide (MDP, 1 microg/mL) with LPS (10 ng/mL) caused significantly elevated values of TNF-alpha and IL-6 in the blood that could not be obtained by the sum of the values obtained by each stimulant alone, or by 3-fold higher doses of either bacterial component alone. Acetylmuramyl-Alanyl-Isoglutamine 63-66 interleukin 6 Homo sapiens 155-159 10679281-3 2000 The PolyG-MDP was found to trigger the secretion of higher levels of interleukin-6, interleukin-1alpha, TNF-alpha, and nitric oxide in comparison to free MDP. Acetylmuramyl-Alanyl-Isoglutamine 10-13 interleukin 6 Homo sapiens 69-82 1761639-7 1991 Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether Fc gamma RI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Acetylmuramyl-Alanyl-Isoglutamine 119-136 interleukin 6 Homo sapiens 9-22 1761639-7 1991 Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether Fc gamma RI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Acetylmuramyl-Alanyl-Isoglutamine 156-173 interleukin 6 Homo sapiens 9-22 1761639-7 1991 Monocyte interleukin-6 downregulation by interleukin-4 is dose dependent and occurs whether Fc gamma RI cross-linking, muramyl dipeptide, indomethacin plus muramyl dipeptide, or interferon-gamma plus muramyl dipeptide is the interleukin-6 inducing stimulus. Acetylmuramyl-Alanyl-Isoglutamine 156-173 interleukin 6 Homo sapiens 9-22 1879927-5 1991 The number of TNF-alpha- and IL-6-secreting cells in either lipopolysaccharide- or muramyl dipeptide-stimulated mononuclear cells from tuberculin-positive healthy subjects and patients was significantly higher than that in cells from the tuberculin-negative healthy subjects. Acetylmuramyl-Alanyl-Isoglutamine 83-100 interleukin 6 Homo sapiens 29-33 1690177-1 1990 We studied IL-6 gene expression in human monocytes stimulated by muramyl dipeptide (MDP), a synthetic immunomodulator derived from mycobacterial cell walls. Acetylmuramyl-Alanyl-Isoglutamine 65-82 interleukin 6 Homo sapiens 11-15 1690177-1 1990 We studied IL-6 gene expression in human monocytes stimulated by muramyl dipeptide (MDP), a synthetic immunomodulator derived from mycobacterial cell walls. Acetylmuramyl-Alanyl-Isoglutamine 84-87 interleukin 6 Homo sapiens 11-15 19180502-10 2009 After up-regulation of NOD-2 by TLR ligands, its ligand muramyl dipeptide (MDP) increased the expression of IL-6 and IL-8 via p38 and NF-kappaB. Acetylmuramyl-Alanyl-Isoglutamine 56-73 interleukin 6 Homo sapiens 108-112 19180502-10 2009 After up-regulation of NOD-2 by TLR ligands, its ligand muramyl dipeptide (MDP) increased the expression of IL-6 and IL-8 via p38 and NF-kappaB. Acetylmuramyl-Alanyl-Isoglutamine 75-78 interleukin 6 Homo sapiens 108-112 33057107-5 2020 MDP water extract significantly inhibited the activation of NF-kappaB and IRF reporters, downstream signaling pathways and the production of IL-6 and TNF-alpha, in a dose-dependent manner. Acetylmuramyl-Alanyl-Isoglutamine 0-3 interleukin 6 Homo sapiens 141-145 31594856-5 2019 However, high amounts of PGE2 and the proinflammatory cytokines IL-1beta and IL-6 were secreted by monocytes activated with MDP in the presence of conditioned medium obtained from CD3 bead-isolated T cells (Tc CM) but not from those isolated without CD3 beads. Acetylmuramyl-Alanyl-Isoglutamine 124-127 interleukin 6 Homo sapiens 77-81 31594856-7 2019 Antibody-mediated blockade of GPIbalpha or of its receptor, Mac-1 integrin, inhibited the secretion of PGE2, IL-1beta, and IL-6 in MDP + Tc CM-activated monocytes, whereas recombinant GPIbalpha protein increased PGE2 production by MDP-treated monocytes. Acetylmuramyl-Alanyl-Isoglutamine 131-134 interleukin 6 Homo sapiens 123-127 30321637-7 2019 After treated by Tri-DAP or MDP, the levels of IL-6 and TNF-alpha in peripheral blood were significantly lower in preterm and term newborns when comparing to adults. Acetylmuramyl-Alanyl-Isoglutamine 28-31 interleukin 6 Homo sapiens 47-51 29471675-8 2018 Moreover, these patients" cells had elevated basal IL-6 secretion that was enhanced by muramyl dipeptide (MDP) stimulation. Acetylmuramyl-Alanyl-Isoglutamine 87-104 interleukin 6 Homo sapiens 51-55 29471675-8 2018 Moreover, these patients" cells had elevated basal IL-6 secretion that was enhanced by muramyl dipeptide (MDP) stimulation. Acetylmuramyl-Alanyl-Isoglutamine 106-109 interleukin 6 Homo sapiens 51-55 25058850-6 2015 MDP (an NLRC2 agonist), NAC and AZM, but not Tri-DAP (an NLRC1 agonist), increased IL-6 production in CF cells, indicating that in CF cells IL-6 upregulation is independent of NLRC1, but involves the activation of NLRC2. Acetylmuramyl-Alanyl-Isoglutamine 0-3 interleukin 6 Homo sapiens 83-87 25058850-6 2015 MDP (an NLRC2 agonist), NAC and AZM, but not Tri-DAP (an NLRC1 agonist), increased IL-6 production in CF cells, indicating that in CF cells IL-6 upregulation is independent of NLRC1, but involves the activation of NLRC2. Acetylmuramyl-Alanyl-Isoglutamine 0-3 interleukin 6 Homo sapiens 140-144