PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16465425-3 2006 In this study, we investigated whether anticancer drugs could directly induce MVP protein or gene expression in the SW-620 human colorectal cancer cell line, in which MVP has been shown to be induced by the differentiation-inducing agent, sodium butyrate (NaB). nab 256-259 major vault protein Homo sapiens 167-170 15161018-5 2004 MATERIALS AND METHODS: We used human colon carcinoma cell lines treated with sodium butyrate (NaB) in order to induce LRP expression. nab 94-97 major vault protein Homo sapiens 118-121 15047174-7 2004 In human cells the MVP promoter was potently stimulated by the histone deacetylase (HDAC) inhibitors butyrate (NaB) and trichostatin A (TSA), resulting in enhanced MVP expression. nab 111-114 major vault protein Homo sapiens 19-22 15047174-7 2004 In human cells the MVP promoter was potently stimulated by the histone deacetylase (HDAC) inhibitors butyrate (NaB) and trichostatin A (TSA), resulting in enhanced MVP expression. nab 111-114 major vault protein Homo sapiens 164-167 12433635-1 2002 OBJECTIVE: To investigate the effect of sodium butyrate (NaB) on the expression level of lung resistance-related protein (LRP) in K562 cells. nab 57-60 major vault protein Homo sapiens 89-120 12917027-2 2003 This study was designed to investigate the effect of sodium butyrate (NaB) on LRP expression level and the function of LRP in K562 cells. nab 70-73 major vault protein Homo sapiens 78-81 12917027-4 2003 The LRP mRNA expression and protein levels in the cells before and after NaB treatment were detected by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and flow cytometry indirect immunofluorescence method,respectively. nab 73-76 major vault protein Homo sapiens 4-7 12917027-6 2003 RESULTS: Compared with untreated K562 cells, the LRP mRNA level in the cells treated with 2 mmol/L NaB was increased obviously; the protein expression were turned from negative result to positive result and the ratios of positive cells were increased from 1.68% to 35.81%. nab 99-102 major vault protein Homo sapiens 49-52 12917027-9 2003 CONCLUSION: Both the mRNA level and the protein expression of LRP in K562 cells can be increased by NaB induction. nab 100-103 major vault protein Homo sapiens 62-65 12917027-10 2003 LRP induced by NaB is involved in the decreasing anti-cancer drug accumulation and transporting the drugs from the nucleus to the cytoplasm in K562 cells. nab 15-18 major vault protein Homo sapiens 0-3 12433635-1 2002 OBJECTIVE: To investigate the effect of sodium butyrate (NaB) on the expression level of lung resistance-related protein (LRP) in K562 cells. nab 57-60 major vault protein Homo sapiens 122-125 12433635-4 2002 RESULTS: A 1-day treatment with 2 mmol/L NaB induced the gene expression of LRP to increase to the maximum in the cells, and a 3-day treatment caused the corresponding protein level to increase to the maximum. nab 41-44 major vault protein Homo sapiens 76-79 12433635-5 2002 CONCLUSION: Both the mRNA level and the protein expression of LRP can be induced by NaB in K562 cells. nab 84-87 major vault protein Homo sapiens 62-65 11149411-2 2001 The levels of expression of LRP mRNA and LRP in a human colon carcinoma cell line, SW-620, were increased by the differentiation-inducing agent, sodium butyrate (NaB). nab 162-165 major vault protein Homo sapiens 28-31 11149411-2 2001 The levels of expression of LRP mRNA and LRP in a human colon carcinoma cell line, SW-620, were increased by the differentiation-inducing agent, sodium butyrate (NaB). nab 162-165 major vault protein Homo sapiens 41-44 11149411-9 2001 PAK-104P and an antibody against LRP increased the accumulation of ADM in the isolated nuclei from NaB-treated cells, and inhibited the enhanced efflux of ADM from the nuclei. nab 99-102 major vault protein Homo sapiens 33-36 10695015-8 1999 Two LRP-specific ribozymes inhibited the NaB-induced expression of LRP in SW-620 cells and almost completely abolished their acquisition of the MDR phenotype. nab 41-44 major vault protein Homo sapiens 4-7 10695015-8 1999 Two LRP-specific ribozymes inhibited the NaB-induced expression of LRP in SW-620 cells and almost completely abolished their acquisition of the MDR phenotype. nab 41-44 major vault protein Homo sapiens 67-70 10695015-12 1999 Efflux of ADM from nuclei isolated from NaB-treated cells was enhanced compared with those from untreated cells and NaB-treated cells transfected with a LRP-specific ribozyme. nab 40-43 major vault protein Homo sapiens 153-156 10695015-12 1999 Efflux of ADM from nuclei isolated from NaB-treated cells was enhanced compared with those from untreated cells and NaB-treated cells transfected with a LRP-specific ribozyme. nab 116-119 major vault protein Homo sapiens 153-156 10695015-13 1999 The polyclonal antibody against LRP inhibited the enhanced efflux of ADM from nuclei isolated from NaB-treated cells. nab 99-102 major vault protein Homo sapiens 32-35 10695015-7 1999 Treatment of human colorectal carcinoma SW-620 cells with sodium butyrate(NaB) induced LRP in the cells and conferred resistance to Adrianycin(ADM), VCR, VP-16, gramicidin D and taxol. nab 74-77 major vault protein Homo sapiens 87-90