PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27611715-4 2016 Our results showed that in the patient"s group the percentage of CD4(+)IL-4(+) cells was significantly increased in the presence of all concentrations of NaB when PBMCs were stimulated by MBP (p = 0.001) or PHA (p < 0.03). nab 154-157 CD4 molecule Homo sapiens 65-68 27941965-9 2016 In HIV-infected participants, each 10% increase in CD4/CD8 ratio predicted a mean 21% higher post-baseline YFV Nab titer (p = 0.024). nab 111-114 CD4 molecule Homo sapiens 51-54 29162799-4 2017 We here employ computational and structure-guided design to develop improved native-like trimers that reduce exposure of non-nAb epitopes in the V3-loop and trimer base, minimize both CD4 reactivity and CD4-induced non-nAb epitope exposure, and increase thermal stability while maintaining bnAb antigenicity. nab 125-128 CD4 molecule Homo sapiens 184-187 29162799-4 2017 We here employ computational and structure-guided design to develop improved native-like trimers that reduce exposure of non-nAb epitopes in the V3-loop and trimer base, minimize both CD4 reactivity and CD4-induced non-nAb epitope exposure, and increase thermal stability while maintaining bnAb antigenicity. nab 125-128 CD4 molecule Homo sapiens 203-206 29162799-4 2017 We here employ computational and structure-guided design to develop improved native-like trimers that reduce exposure of non-nAb epitopes in the V3-loop and trimer base, minimize both CD4 reactivity and CD4-induced non-nAb epitope exposure, and increase thermal stability while maintaining bnAb antigenicity. nab 219-222 CD4 molecule Homo sapiens 203-206 28539451-8 2017 The additional introduction of the E64K ground-state stabilizing substitution markedly reduced or ablated soluble CD4 (sCD4) induction of non-NAb epitopes in V3 and/or associated with the coreceptor binding site. nab 142-145 CD4 molecule Homo sapiens 114-117 28279830-2 2017 In new immunizations, we attempted to improve nAb responses by removing the N362 glycan that also lines the CD4bs. nab 46-49 CD4 molecule Homo sapiens 108-111 27611715-6 2016 Moreover, in the patient"s group the percentage of CD4(+)IFN-gamma(+) cells was decreased significantly when the PBMCs were stimulated by PHA and NaB (p < 0.004) or by MBP and 1000 microg/ml of NaB (p < 0.03). nab 146-149 CD4 molecule Homo sapiens 51-54 27611715-6 2016 Moreover, in the patient"s group the percentage of CD4(+)IFN-gamma(+) cells was decreased significantly when the PBMCs were stimulated by PHA and NaB (p < 0.004) or by MBP and 1000 microg/ml of NaB (p < 0.03). nab 197-200 CD4 molecule Homo sapiens 51-54 19567243-5 2009 The NAb specificities for SOSIP antisera mapped in part to the CD4 binding site on gp120. nab 4-7 CD4 molecule Homo sapiens 63-66 20860805-9 2010 Interestingly, we found that the sensitivity of Envs to contemporaneous autologous NAbs correlated positively with increased sensitivity to soluble CD4 and inversely with anti-CD4 antibody and Envs with increased NAb sensitivity were able to efficiently infect HeLa cells expressing low CD4. nab 83-86 CD4 molecule Homo sapiens 148-151 20860805-9 2010 Interestingly, we found that the sensitivity of Envs to contemporaneous autologous NAbs correlated positively with increased sensitivity to soluble CD4 and inversely with anti-CD4 antibody and Envs with increased NAb sensitivity were able to efficiently infect HeLa cells expressing low CD4. nab 83-86 CD4 molecule Homo sapiens 176-179 20860805-9 2010 Interestingly, we found that the sensitivity of Envs to contemporaneous autologous NAbs correlated positively with increased sensitivity to soluble CD4 and inversely with anti-CD4 antibody and Envs with increased NAb sensitivity were able to efficiently infect HeLa cells expressing low CD4. nab 83-86 CD4 molecule Homo sapiens 176-179