PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21459573-1	2011	We report the use of a fragment-based lead discovery method, Tethering with extenders, to discover a pyridinone fragment that binds in an adaptive site of the protein PDK1.	Pyridones	101-111	pyruvate dehydrogenase kinase 1	Homo sapiens	167-171