PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27834956-3 2017 In the present study, we discovered that mitochondrial perturbations play a critical role in Smac mimetic/Dexamethasone (Dexa)-induced necroptosis independently of death receptor ligands. Dexa-BEAM protocol 106-110 diablo, IAP-binding mitochondrial protein Mus musculus 93-97 27834956-4 2017 We demonstrate that the Smac mimetic BV6 and Dexa cooperate to trigger necroptotic cell death in acute lymphoblastic leukemia (ALL) cells that are deficient in caspase activation due to absent caspase-8 expression or pharmacological inhibition by the caspase inhibitor zVAD.fmk, since genetic silencing or pharmacological inhibition of RIP3 or MLKL significantly rescue BV6/Dexa-induced necroptosis. Dexa-BEAM protocol 45-49 diablo, IAP-binding mitochondrial protein Mus musculus 24-28 27834956-4 2017 We demonstrate that the Smac mimetic BV6 and Dexa cooperate to trigger necroptotic cell death in acute lymphoblastic leukemia (ALL) cells that are deficient in caspase activation due to absent caspase-8 expression or pharmacological inhibition by the caspase inhibitor zVAD.fmk, since genetic silencing or pharmacological inhibition of RIP3 or MLKL significantly rescue BV6/Dexa-induced necroptosis. Dexa-BEAM protocol 374-378 diablo, IAP-binding mitochondrial protein Mus musculus 24-28