PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2273938-7	1990	Levels of cytochrome P-450 IIIA4 vary widely among individuals and can explain the variation in rates of 17 alpha-ethynylestradiol 2-hydroxylation.	Ethinyl Estradiol	105-130	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	10-26	
9723818-9	1998	The changes in ethinyl oestradiol pharmacokinetics were consistent with an increase in clearance from enzymatic induction of glucuronidation and/or cytochrome P450 hydroxylation.	Ethinyl Estradiol	15-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	148-163	
2273938-9	1990	Mechanism-based inactivation of cytochrome P-450 IIIA4 can be seen with 17 alpha-ethynylestradiol and other 17 alpha-acetylenic steroids, and the progestogen gestodene appears to be unusually active in this regard.	Ethinyl Estradiol	72-97	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	32-48	
2273938-10	1990	Other unknown factors may also modulate levels of cytochrome P-450 IIIA4 and its ability to catalyze 17 alpha-ethynylestradiol 2-hydroxylation.	Ethinyl Estradiol	101-126	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	50-66	
3285175-8	1988	Additional experiments did not show any evidence for the involvement of a number of other human cytochrome P-450 enzymes in 17 alpha-ethynylestradiol 2-hydroxylation (i.e., P-450DB, P-450PA, P-450MP, P-450j).	Ethinyl Estradiol	124-149	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	96-112	
3285175-0	1988	Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.	Ethinyl Estradiol	13-38	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	54-70	
3285175-7	1988	In addition, 17 alpha-ethynylestradiol appears to be a mechanism-based inhibitor in human liver microsomes, as shown by the loss of both spectrally detectable cytochrome P-450 and 17 alpha-ethynylestradiol 2-hydroxylase activity during incubation in the presence of NADPH.	Ethinyl Estradiol	13-38	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	159-175	
925482-5	1977	This was confirmed by studies of the effect of ethinyl estradiol on the level of microsomal cytochrome P-450 over a 10-day period.	Ethinyl Estradiol	47-64	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-108	
925482-2	1977	After 5 days of ethinyl estradiol, 5 mg/kg/day, there was a significant decrease in the activity of ethylmorphine-N-demethylase and in cytochrome P-450, cytochrome b2, and NADPH cytochrome c reductase.	Ethinyl Estradiol	16-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	135-151	
925482-4	1977	After 5 days of ethinyl estradiol administration, the rate of degradation of cytochrome P-450 apoprotein was reduced (half-life of 50 hr compared to 24 hr in control), and their relative rate of synthesis was likewise reduced, indicating that a new steady state of protein turnover associated with reduced synthesis rate had been reached.	Ethinyl Estradiol	16-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	77-93