PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16842099-1 2006 Lead compounds directed to the 5" leader of the Amyloid Precursor Protein transcript (i.e., paroxetine (SSRI), N-acetyl cysteine (antioxidant), and erythromycin (macrolide antibiotic)) were employed in a pilot study to evaluate their anti-amyloid efficacy in the TgCRND8 transgenic mouse model for Alzheimer"s Disease (AD). Paroxetine 92-102 amyloid beta (A4) precursor protein Mus musculus 48-73 16842099-2 2006 The relative levels of Abeta peptide were reduced after exposure of mice to paroxetine (N=5), NAC (N=7), and erythromycin (N=7) relative to matched placebo counterparts. Paroxetine 76-86 amyloid beta (A4) precursor protein Mus musculus 23-28 16842099-3 2006 Paroxetine limited the levels of APP holoprotein and total Abeta peptide levels (measurements of Abeta were performed at two separate sites by quantitative western blotting and ELISA assay). Paroxetine 0-10 amyloid beta (A4) precursor protein Mus musculus 59-64 15974925-4 2005 The relative levels of Abeta peptide levels were reduced after exposure of mice to paroxetine (N=5), NAC (N=7), and erythromycin (N=7) relative to matched placebo counterparts. Paroxetine 83-93 amyloid beta (A4) precursor protein Mus musculus 23-28 17368447-7 2007 Levels of amyloid beta-peptide (Abeta) and numbers of Abeta immunoreactive neurons were significantly reduced in the hippocampus of male and female paroxetine-treated 3xTgAD mice compared to saline-treated 3xTgAD mice. Paroxetine 148-158 amyloid beta (A4) precursor protein Mus musculus 32-37 17368447-7 2007 Levels of amyloid beta-peptide (Abeta) and numbers of Abeta immunoreactive neurons were significantly reduced in the hippocampus of male and female paroxetine-treated 3xTgAD mice compared to saline-treated 3xTgAD mice. Paroxetine 148-158 amyloid beta (A4) precursor protein Mus musculus 54-59