PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32024542-6 2020 RESULTS: Paroxetine had no impact on LPS-stimulated iNOS, TNF-alpha, and IL-1beta expression, but inhibited M/Lps-induced TNF-alpha and IL-1beta expression in primary astrocytes. Paroxetine 9-19 interleukin 1 alpha Homo sapiens 136-144 33602262-7 2021 RESULTS: All the SSRIs, including paroxetine, fluoxetine, sertraline, citalopram, and fluvoxamine, show a visible cytotoxicity within the range of applied doses, and a paradoxical effect on astrocytic inflammatory responses as manifested by the promotion of inducible nitric oxide synthase (iNOS) and/or nitric oxide (NO) and the inhibition of interleukin 6 (IL-6) and/or interleukin 1beta (IL-1beta). Paroxetine 34-44 interleukin 1 alpha Homo sapiens 391-399 32020710-5 2020 Our results indicated that paroxetine attenuates proinflammatory cytokine production (interleukin-1beta [IL-1beta], IL-17, and tumor necrosis factor-alpha) and increases expression of IL-10 and JAK2/STAT3 evidence for macrophages polarization to M2 subset and functional dendritic cells depletion. Paroxetine 27-37 interleukin 1 alpha Homo sapiens 105-113