PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25849320-5 2016 Lithium and the antidepressant (AD) paroxetine (PAR) functionally synergize with FKBP51, as revealed by reporter gene and protein association analyses. Paroxetine 36-46 FK506 binding protein 5 Mus musculus 81-87 25849320-5 2016 Lithium and the antidepressant (AD) paroxetine (PAR) functionally synergize with FKBP51, as revealed by reporter gene and protein association analyses. Paroxetine 48-51 FK506 binding protein 5 Mus musculus 81-87 26602018-0 2015 Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. Paroxetine 118-128 FK506 binding protein 5 Mus musculus 25-31 26602018-5 2015 In mouse embryonic fibroblasts and primary mouse astrocytes, FKBP51 mediated several effects of paroxetine, namely, decreased the protein-protein interactions of DNMT1 with CDK5 and FKBP52, reduced phosphorylation of DNMT1, and decreased the methylation and increased the expression of the gene encoding brain-derived neurotrophic factor (Bdnf). Paroxetine 96-106 FK506 binding protein 5 Mus musculus 61-67 26602018-7 2015 Peripheral blood cells isolated from depressed patients that were then treated ex vivo with paroxetine revealed that the abundance of BDNF positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 in cells and with clinical treatment success in patients, supporting the relevance of this FKBP51-directed pathway that prevents epigenetic suppression of gene expression. Paroxetine 92-102 FK506 binding protein 5 Mus musculus 220-226 25386878-11 2014 Using chronic social defeat as a depression-relevant stress model in combination with chronic paroxetine (PAR) treatment revealed that the stress response, as well as the effects of antidepressants on behavior and autophagic markers, depends on FKBP51. Paroxetine 94-104 FK506 binding protein 5 Mus musculus 245-251 25386878-11 2014 Using chronic social defeat as a depression-relevant stress model in combination with chronic paroxetine (PAR) treatment revealed that the stress response, as well as the effects of antidepressants on behavior and autophagic markers, depends on FKBP51. Paroxetine 106-109 FK506 binding protein 5 Mus musculus 245-251