PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18592413-6 2008 In rat hippocampal neurons, prolonged (72-hour) treatment with selective serotonin reuptake inhibitors paroxetine and citalopram significantly up-regulated BDNF and PACAP expression and down-regulated PACAP receptor (PAC1 and VPAC2) expression; the tricyclic antidepressant imipramine had an opposite effect. Paroxetine 103-113 brain-derived neurotrophic factor Rattus norvegicus 156-160 16143352-11 2005 The results suggest that paroxetine, but not desipramine, enhances synaptic plasticity in the hippocampus by increasing BDNF mRNA expression, which determines a later AMPAR subunit trafficking to synaptic membranes. Paroxetine 25-35 brain-derived neurotrophic factor Rattus norvegicus 120-124 16143352-3 2005 Here we looked for the time course of the effect of different doses of two antidepressants, desipramine (DMI) and paroxetine (PAR), which differentially affect monoamine reuptake, on BDNF mRNA expression in hippocampal subfields (CA1, CA3 and dentate gyrus) and levels of AMPAR subunits in total and membrane-enriched extracts from rat hippocampus. Paroxetine 114-124 brain-derived neurotrophic factor Rattus norvegicus 183-187 16143352-3 2005 Here we looked for the time course of the effect of different doses of two antidepressants, desipramine (DMI) and paroxetine (PAR), which differentially affect monoamine reuptake, on BDNF mRNA expression in hippocampal subfields (CA1, CA3 and dentate gyrus) and levels of AMPAR subunits in total and membrane-enriched extracts from rat hippocampus. Paroxetine 126-129 brain-derived neurotrophic factor Rattus norvegicus 183-187 12726822-4 2003 A down-regulation of the BDNF gene was detected at 4 h (TCP and fluoxetine) and an up-regulation at 24 h (TCP, paroxetine, fluoxetine, sertraline) after the last of twice daily injections for 14 days. Paroxetine 111-121 brain-derived neurotrophic factor Rattus norvegicus 25-29 33347827-8 2021 This affirmative function of paroxetine on the passive avoidance memory was accompanied by the improvement of hippocampal LTP and an obvious augmentation in the BDNF contents. Paroxetine 29-39 brain-derived neurotrophic factor Rattus norvegicus 161-165 10428425-8 1999 Paroxetine also reduced BDNF mRNA in DG but was without effect in frontal cortex. Paroxetine 0-10 brain-derived neurotrophic factor Rattus norvegicus 24-28 33908307-14 2021 CONCLUSION: These findings point towards potential synergistic efficacies of tDCS and paroxetine in the OBX model of adolescent depression via mechanisms associated with altered expression of BDNF, 5-HT1A, SERT and zif268 in discrete corticolimbic areas. Paroxetine 86-96 brain-derived neurotrophic factor Rattus norvegicus 192-196 33347827-10 2021 It was ultimately attained that paroxetine attenuates cerebral ischemia-induced passive avoidance memory dysfunction in rats by the enhancement of hippocampal synaptic plasticity and BDNF content together with the suppression of oxidative/nitrosative stress. Paroxetine 32-42 brain-derived neurotrophic factor Rattus norvegicus 183-187 32429644-8 2020 Results: In the preventive study, paroxetine decreased BDNF and increased KCC2 and GABAA gene and protein expression, while in the post-injury paradigm, it decreased BDNF and increased KCC2 genes and protein expression. Paroxetine 34-44 brain-derived neurotrophic factor Rattus norvegicus 55-59 32429644-8 2020 Results: In the preventive study, paroxetine decreased BDNF and increased KCC2 and GABAA gene and protein expression, while in the post-injury paradigm, it decreased BDNF and increased KCC2 genes and protein expression. Paroxetine 34-44 brain-derived neurotrophic factor Rattus norvegicus 166-170 23291919-6 2013 In addition, the elevated protein levels of phosphorylated ERK1/2, Bcl-2, and brain-derived neurotrophic factor were also observed after paroxetine was administered. Paroxetine 137-147 brain-derived neurotrophic factor Rattus norvegicus 78-111 24296153-5 2014 Escitalopram, fluoxetine, paroxetine, sertraline, imipramine, tranylcypromine, and tianeptine significantly prevented B27 deprivation-induced decreases in levels of PSD-95, BDNF, and SYP. Paroxetine 26-36 brain-derived neurotrophic factor Rattus norvegicus 173-177 24296153-6 2014 Moreover, the independent application of fluoxetine, paroxetine, and sertraline significantly increased levels of BDNF under normal conditions. Paroxetine 53-63 brain-derived neurotrophic factor Rattus norvegicus 114-118 29217494-12 2018 Compared with the normal group, the mRNA of NCAM, CREB and BDNF were significantly down-regulated (p < 0.001) in the control group, BDNF gene was up-regulated by paroxetine or XYS treatment, NCAM and CREB gene did not change in XYS group, protein expressions of BDNF and CREB were significantly increased, and NCAM was significantly reduced (p < 0.05). Paroxetine 165-175 brain-derived neurotrophic factor Rattus norvegicus 135-139 29217494-12 2018 Compared with the normal group, the mRNA of NCAM, CREB and BDNF were significantly down-regulated (p < 0.001) in the control group, BDNF gene was up-regulated by paroxetine or XYS treatment, NCAM and CREB gene did not change in XYS group, protein expressions of BDNF and CREB were significantly increased, and NCAM was significantly reduced (p < 0.05). Paroxetine 165-175 brain-derived neurotrophic factor Rattus norvegicus 135-139 21930121-0 2011 Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression. Paroxetine 55-65 brain-derived neurotrophic factor Rattus norvegicus 81-85 21930121-11 2011 The inhibitory action by the selective serotonin re-uptake inhibitor (SSRI) paroxetine on hippocampal BDNF mRNA was also attenuated by CGP 46381. Paroxetine 76-86 brain-derived neurotrophic factor Rattus norvegicus 102-106 20435092-8 2010 This absence of any significant increase in BDNF protein levels in the hippocampus, and the persistence in this region of decreases in TpH IR axon density and [(3)H]-paroxetine-binding, raises the possibility that BDNF has an important role in the long-term recovery of serotonergic axons after MDMA treatment. Paroxetine 166-176 brain-derived neurotrophic factor Rattus norvegicus 214-218