PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33372534-0 2021 Paroxetine Attenuates Cardiac Hypertrophy Via Blocking GRK2 and ADRB1 Interaction in Hypertension. Paroxetine 0-10 adrenoceptor beta 1 Homo sapiens 64-69 33372534-5 2021 Meanwhile, we discovered a selective serotonin reuptake inhibitor paroxetine specifically blockades GRK2 and ADRB1 interaction. Paroxetine 66-76 adrenoceptor beta 1 Homo sapiens 109-114 33372534-8 2021 Paroxetine treatment also blocks epinephrine-induced upregulation of hypertrophic and fibrotic genes as well as ADRB1 internalization in cardiomyocytes. Paroxetine 0-10 adrenoceptor beta 1 Homo sapiens 112-117 33372534-11 2021 Conclusions Paroxetine promotes ADRB1 sensitivity and attenuates cardiac hypertrophy partially via blocking GRK2-mediated ADRB1 activation and internalization in the context of hypertension. Paroxetine 12-22 adrenoceptor beta 1 Homo sapiens 32-37 33372534-11 2021 Conclusions Paroxetine promotes ADRB1 sensitivity and attenuates cardiac hypertrophy partially via blocking GRK2-mediated ADRB1 activation and internalization in the context of hypertension. Paroxetine 12-22 adrenoceptor beta 1 Homo sapiens 122-127