PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6768169-0 1980 Induction of liver microsomal NADPH cytochrome C reductase and cytochrome P-450 by some new synthetic pyrethroids. Pyrethrins 102-113 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-79 29779438-1 2019 The metabolism of the pyrethroids deltamethrin (DLM), cis-permethrin (CPM) and trans-permethrin (TPM) was studied in human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. Pyrethrins 22-33 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 150-153 32672501-2 2020 Pyrethroid metabolism was also studied with some human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. Pyrethrins 0-10 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 65-80 32672501-2 2020 Pyrethroid metabolism was also studied with some human expressed cytochrome P450 (CYP) and carboxylesterase (CES) enzymes. Pyrethrins 0-10 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 82-85 32672501-10 2020 All pyrethroids were metabolised by some of the human expressed CYP enzymes studied and apart from BIF were also metabolised by CES enzymes. Pyrethrins 4-15 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-67 29779438-3 2019 Other CYP enzymes contributing to the metabolism of one or more of the three pyrethroids were CYP1A2, CYP2C8, CYP2C9*1, CYP2D6*1, CYP3A4 and CYP3A5. Pyrethrins 77-88 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-9 29779438-6 2019 Apparent CLint values for pyrethroid metabolism by CYP and CES enzymes were scaled to per gram of adult human liver using abundance values for microsomal CYP enzymes and for CES enzymes in liver microsomes and cytosol. Pyrethrins 26-36 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 51-54 29779438-8 2019 Due to their higher abundance, all three pyrethroids were extensively metabolised by CES enzymes in adult human liver, with CYP enzymes only accounting for 2%, 10% and 1% of total metabolism for DLM, CPM and TPM, respectively. Pyrethrins 41-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 124-127