PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24147136-8	2013	CREB and its co-activator CRTC2, both activated by fasting stimuli, contribute to glucagon-stimulated Nedd4l-short expression in primary hepatocytes.	Glucagon	82-90	cAMP responsive element binding protein 1	Mus musculus	0-4	
22315325-9	2012	Glucagon action was examined using glucagon tolerance tests and glucagon-stimulated HGP, cAMP-responsive element-binding (CREB) phosphorylation, and expression of gluconeogenic genes in the liver and primary hepatocytes.	Glucagon	0-8	cAMP responsive element binding protein 1	Mus musculus	122-126	
22315325-9	2012	Glucagon action was examined using glucagon tolerance tests and glucagon-stimulated HGP, cAMP-responsive element-binding (CREB) phosphorylation, and expression of gluconeogenic genes in the liver and primary hepatocytes.	Glucagon	64-72	cAMP responsive element binding protein 1	Mus musculus	122-126	
22315325-14	2012	In addition, TRAF2 overexpression significantly increased the ability of glucagon or a cAMP analog to stimulate CREB phosphorylation, gluconeogenic gene expression, and HGP in primary hepatocytes.	Glucagon	73-81	cAMP responsive element binding protein 1	Mus musculus	112-116	
14988413-0	2004	Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans.	Glucagon	0-8	cAMP responsive element binding protein 1	Mus musculus	18-55	
21803292-3	2011	In one model, the main CBP interaction with the glucagon-responsive factor CREB is not limiting for liver gluconeogenesis, whereas a second model posits that Ser436 in the CH1 (TAZ1) domain of CBP is required for insulin and the antidiabetic drug metformin to inhibit CREB-mediated liver gluconeogenesis.	Glucagon	48-56	cAMP responsive element binding protein 1	Mus musculus	75-79	
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Glucagon	26-34	cAMP responsive element binding protein 1	Mus musculus	149-186	
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Glucagon	26-34	cAMP responsive element binding protein 1	Mus musculus	188-192	
14988413-9	2004	Our results uncover a novel mechanism by which the PKA/ERK1/2 signaling network engaged by glucagon, in situation of low glucose concentration, regulates phosphorylation of CREB, a transcription factor crucial for normal beta cell function and survival.	Glucagon	91-99	cAMP responsive element binding protein 1	Mus musculus	173-177	
14988413-7	2004	Miniglucagon, produced from glucagon and released together with the mother hormone from the alpha cells in low glucose situations, blocks the insulinotropic effect of glucagon, whereas it does not inhibit the glucagon-induced PKA/ERK1/2/CREB pathway.	Glucagon	4-12	cAMP responsive element binding protein 1	Mus musculus	237-241	
30260029-9	2019	CREB-induced MEG3 upregulation increased gluconeogenic gene expression in high glucagon-treated primary hepatocytes, while MEG3 interference led to an opposite effect.	Glucagon	79-87	cAMP responsive element binding protein 1	Mus musculus	0-4	
26021821-11	2015	Glucagon induced CREB and NOS-3 phosphorylation and increased PGE2 levels in the lung tissue without altering COX-1 expression.	Glucagon	0-8	cAMP responsive element binding protein 1	Mus musculus	17-21	
26038839-5	2015	8-Br-cADPR, an antagonistic cADPR analog, completely blocked glucagon-induced Ca(2+) increases and phosphorylation of cAMP response element-binding protein (CREB).	Glucagon	61-69	cAMP responsive element binding protein 1	Mus musculus	118-155	
26038839-5	2015	8-Br-cADPR, an antagonistic cADPR analog, completely blocked glucagon-induced Ca(2+) increases and phosphorylation of cAMP response element-binding protein (CREB).	Glucagon	61-69	cAMP responsive element binding protein 1	Mus musculus	157-161	
25730876-3	2015	Here we show that acute ethanol exposure also lowers fasting blood glucose concentrations by inhibiting the CREB-mediated activation of the gluconeogenic program in response to glucagon.	Glucagon	177-185	cAMP responsive element binding protein 1	Mus musculus	108-112