PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11037108-5 2000 Human CYP probe substrates used for characterization of mouse CYP activities included bufuralol, testosterone, dextromethorphan, phenacetin, diclofenac and S-mephenytoin. bufuralol 86-95 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-9 11037108-5 2000 Human CYP probe substrates used for characterization of mouse CYP activities included bufuralol, testosterone, dextromethorphan, phenacetin, diclofenac and S-mephenytoin. bufuralol 86-95 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-65 3745165-1 1986 Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol. bufuralol 164-173 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-92 7935340-1 1994 Bufuralol 1"-hydroxylation is a prototypical reaction catalyzed by cytochrome P450 (P450) 2D6, an enzyme known to show debrisoquine/sparteine-type genetic polymorphism in humans. bufuralol 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-93 2233418-1 1990 The possibility that idiopathic Parkinson"s disease may be linked to a deficiency of an important detoxifying enzyme such as the cytochrome P450 enzyme bufuralol hydroxylase is examined. bufuralol 152-161 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 129-144 2910635-10 1989 Thus it can be concluded that 5-hydroxypropafenone is formed by the cytochrome P-450 isozyme involved in polymorphic bufuralol oxidation. bufuralol 117-126 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 68-84 3186722-4 1988 Using two assay systems with different selectivity for the two cytochrome P-450 isozymes catalyzing bufuralol metabolism in human liver, we show that anti-LKM1 exclusively recognizes cytochrome P-450db1. bufuralol 100-109 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 63-79 9820175-5 1998 Specific substrates of CYP included testosterone (catalysed by CYP3A4), paclitaxel (CYP2C8), 7-ethoxyresorufin (CYP1A1, CYP1A2), coumarin (CYP2A6), aniline (CYP2E1) and (+/-)-bufuralol (CYP2D6). bufuralol 169-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 23-26 3689440-3 1987 In order to elucidate the mechanisms underlying the differences in cytochrome P-450 function we have studied the 1"-hydroxylation of the prototype drug bufuralol in human liver microsomes of individuals phenotyped in vivo as extensive metabolizers (EM, N = 10), poor metabolizers (PM, N = 5) and in subjects with an intermediate rate of metabolism (IM, N = 4). bufuralol 152-161 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-83 3689440-6 1987 Inhibition of bufuralol 1"-hydroxylation by quinidine was biphasic in EM microsomes, providing further support for the involvement of at least two cytochrome P-450 isozymes. bufuralol 14-23 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 147-163 3689440-8 1987 Our data suggest that the debrisoquine/sparteine type of oxidation polymorphism is caused by an almost complete loss of a minor cytochrome P-450 isozyme which has a high affinity and stereoselectivity for (+)-bufuralol and a high sensitivity to inhibition by quinidine. bufuralol 205-218 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 128-144 32279279-3 2020 METHODS: The activity of these enzymes was determined by the following CYP-specific reactions: caffeine 3-N-demethylation/CYP1A2, diclofenac 4"-hydroxylation/CYP2C9, perazine N-demethylation/CYP2C19, bufuralol 1"-hydroxylation/CYP2D6 and testosterone 6beta-hydroxylation/CYP3A4, respectively, using HPLC. bufuralol 200-209 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-74 3966916-5 1985 The competitive inhibition of debrisoquine and bufuralol of each other"s metabolism, together with the similarity in the values for Km and Ki, support the conclusion that the same form of cytochrome P-450 catalyses these two reactions. bufuralol 47-56 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 188-204 6508804-0 1984 Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1"-hydroxylation in poor metabolizers. bufuralol 187-196 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-63 2874666-0 1986 The molecular mechanisms of two common polymorphisms of drug oxidation--evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation. bufuralol 144-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 107-123 2874666-4 1986 A structural model of the active site of a cytochrome P-450 for stereospecific metabolism of bufuralol and other polymorphically metabolized substrates was constructed. bufuralol 93-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-59 2874666-5 1986 Two cytochrome P-450 isozymes, P-450 buf I and P-450 buf II, both with MW 50,000 Da, were purified from human liver on the basis of their ability to metabolize bufuralol to 1"-hydroxy-bufuralol. bufuralol 160-169 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 26481538-4 2015 CYP isoenzyme activities were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6) and testosterone 6beta-hydroxylation (CYP3A4). bufuralol 186-195 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 32219694-4 2020 Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4). bufuralol 187-196 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-17 32219694-4 2020 Activities of CYP enzymes were determined using the CYP-specific reactions: caffeine 3-N-demethylation (CYP1A2), diclofenac 4"-hydroxylation (CYP2C9), perazine N-demethylation (CYP2C19), bufuralol 1"-hydroxylation (CYP2D6), and testosterone 6beta-hydroxylation (CYP3A4). bufuralol 187-196 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-55