PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19501039-13	2009	The turnover of 15-PGDH was found to prolong in the presence of flurbiprofen as compared to that in the absence of this drug.	Flurbiprofen	64-76	carbonyl reductase 1	Homo sapiens	16-23	
21763448-6	2011	Flurbiprofen, indomethacin and other NSAIDs stimulated 15-PGDH activity in colon cancer HT29 cells as well as in lung cancer A549 cells and glioblastoma T98G cells.	Flurbiprofen	0-12	carbonyl reductase 1	Homo sapiens	55-62	
21763448-7	2011	(R)-flurbiprofen and sulindac sulfone, COX-2 inactive analogs, also stimulated 15-PGDH activity indicating induction of 15-PGDH is independent of COX-2 inhibition.	Flurbiprofen	0-16	carbonyl reductase 1	Homo sapiens	79-86	
21763448-7	2011	(R)-flurbiprofen and sulindac sulfone, COX-2 inactive analogs, also stimulated 15-PGDH activity indicating induction of 15-PGDH is independent of COX-2 inhibition.	Flurbiprofen	0-16	carbonyl reductase 1	Homo sapiens	120-127	
21763448-8	2011	Stimulation of 15-PGDH expression and activity by NSAIDs was examined in detail in colon cancer HT29 cells using flurbiprofen as a stimulant.	Flurbiprofen	113-125	carbonyl reductase 1	Homo sapiens	15-22	
21763448-9	2011	Flurbiprofen stimulated 15-PGDH expression and activity by increasing transcription and translation and by decreasing the turnover of 15-PGDH.	Flurbiprofen	0-12	carbonyl reductase 1	Homo sapiens	24-31	
21763448-9	2011	Flurbiprofen stimulated 15-PGDH expression and activity by increasing transcription and translation and by decreasing the turnover of 15-PGDH.	Flurbiprofen	0-12	carbonyl reductase 1	Homo sapiens	134-141	
21763448-12	2011	However, flurbiprofen down-regulated matrix metalloproteinase-9 (MMP-9) which was shown to degrade 15-PGDH, but up-regulated tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9 contributing further to a slower turnover of 15-PGDH.	Flurbiprofen	9-21	carbonyl reductase 1	Homo sapiens	99-106	
21763448-12	2011	However, flurbiprofen down-regulated matrix metalloproteinase-9 (MMP-9) which was shown to degrade 15-PGDH, but up-regulated tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9 contributing further to a slower turnover of 15-PGDH.	Flurbiprofen	9-21	carbonyl reductase 1	Homo sapiens	242-249	
19501039-0	2009	15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.	Flurbiprofen	67-79	carbonyl reductase 1	Homo sapiens	0-37	
19501039-0	2009	15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.	Flurbiprofen	67-79	carbonyl reductase 1	Homo sapiens	39-46	
19501039-4	2009	Flurbiprofen and several other NSAIDs were found to induce 15-PGDH expression in human colon cancer HT29 cells.	Flurbiprofen	0-12	carbonyl reductase 1	Homo sapiens	59-66	
19501039-5	2009	Flurbiprofen, the most active one, was also shown to induce 15-PGDH expression in other types of cancer cells.	Flurbiprofen	0-12	carbonyl reductase 1	Homo sapiens	60-67	
19501039-6	2009	Induction of 15-PGDH expression appeared to occur at the stage of mRNA as levels of 15-PGDH mRNA were increased by flurbiprofen in HT29 cells.	Flurbiprofen	115-127	carbonyl reductase 1	Homo sapiens	13-20	
19501039-6	2009	Induction of 15-PGDH expression appeared to occur at the stage of mRNA as levels of 15-PGDH mRNA were increased by flurbiprofen in HT29 cells.	Flurbiprofen	115-127	carbonyl reductase 1	Homo sapiens	84-91	
19501039-14	2009	Taken together, these results indicate that flurbiprofen up-regulates 15-PGDH by increasing the expression and decreasing the degradation of 15-PGDH in HT29 cells.	Flurbiprofen	44-56	carbonyl reductase 1	Homo sapiens	70-77	
19501039-14	2009	Taken together, these results indicate that flurbiprofen up-regulates 15-PGDH by increasing the expression and decreasing the degradation of 15-PGDH in HT29 cells.	Flurbiprofen	44-56	carbonyl reductase 1	Homo sapiens	141-148