PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34119518-0	2021	Akt / GSK3beta / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity.	Flurbiprofen	51-63	AKT serine/threonine kinase 1	Rattus norvegicus	0-3	
34119518-11	2021	In our research we aimed to test the hypothesis that flurbiprofen may have a neuroprotective effect in a rat model of glutamate-induced excitotoxicity and this neuroprotection may occur through modulation of (Akt/GSK3beta/Nrf2/HO-1) pathway.	Flurbiprofen	53-65	AKT serine/threonine kinase 1	Rattus norvegicus	209-212	
21624354-0	2011	The Akt/GSK-3beta pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats.	Flurbiprofen	35-47	AKT serine/threonine kinase 1	Rattus norvegicus	4-7	
21624354-3	2011	This study aimed to investigate the potential association between the neuroprotective effect of flurbiprofen and the apoptosis inhibiting signaling pathways, in particularly the Akt/GSK-3beta pathway.	Flurbiprofen	96-108	AKT serine/threonine kinase 1	Rattus norvegicus	178-181	
21624354-8	2011	Moreover, flurbiprofen not only inhibited the expression of Bax protein and p-GSK-3beta, but also increased the expression of Bcl-2 protein, the ratio of Bcl-2/Bax as well as the P-Akt level.	Flurbiprofen	10-22	AKT serine/threonine kinase 1	Rattus norvegicus	181-184	
21624354-9	2011	Taken together, these results suggest that flurbiprofen protects the brain from ischemia/reperfusion injury by reducing apoptosis and this neuroprotective effect may be partly due to the activation of Akt/GSK-3beta signaling pathway.	Flurbiprofen	43-55	AKT serine/threonine kinase 1	Rattus norvegicus	201-204