PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11672885-4 2001 All the compounds were shown to be docked at the site where intact flurbiprofen was embedded for COX-1 and s-58 (1-phenylsulphonamide-3-trifluoromethyl-5-para-bromophenylpyrazole) for COX-2. Flurbiprofen 67-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 184-189 15878913-6 2005 The upregulation of cox-2 and cPLA2 was inhibited by flurbiprofen, a cyclooxygenase (COX) inhibitor, making this a second feed-forward enzyme in the eicosanoid pathway. Flurbiprofen 53-65 mitochondrially encoded cytochrome c oxidase II Homo sapiens 20-25 15680249-3 2005 We show that, in cytokine-treated synoviocytes (from non-rheumatic patients), NO-naproxen and NO-flurbiprofen like their parent compounds concentration-dependently reduce the levels of PGE2 (an index of COX-2 activity), with a corresponding rise in the release of GM-CSF. Flurbiprofen 97-109 mitochondrially encoded cytochrome c oxidase II Homo sapiens 203-208 11687965-8 2001 Curiously, treatment of the cells with flurbiprofen enhanced the level of COX-2 expression. Flurbiprofen 39-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 74-79 11687965-10 2001 These observations suggest that the interaction of COX-2 with p53 may cause p21-independent suppression of tumor cell growth upon flurbiprofen treatment. Flurbiprofen 130-142 mitochondrially encoded cytochrome c oxidase II Homo sapiens 51-56 25467164-3 2014 Ibuprofen-5-HT and Flurbiprofen-5-HT inhibited all three targets with approximately the same potency as N-arachidonoyl serotonin (AA-5-HT), while Fenoprofen-5-HT and Naproxen-5-HT showed activity as dual inhibitors of TRPV1 and COX2. Flurbiprofen 19-31 mitochondrially encoded cytochrome c oxidase II Homo sapiens 228-232 12517972-2 2003 We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells. Flurbiprofen 48-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-123 12517972-2 2003 We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells. Flurbiprofen 48-60 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-123 12517972-2 2003 We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells. Flurbiprofen 62-66 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-123 12517972-2 2003 We show in this study that indomethacin (Indo), flurbiprofen (Flur), and the selective COX-2 inhibitor NS-398 induced COX-2 expression and markedly enhanced IL-1beta-induced COX-2 expression in human airway smooth muscle (HASM) cells. Flurbiprofen 62-66 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-123 10091674-0 1999 Structure-based design of COX-2 selectivity into flurbiprofen. Flurbiprofen 49-61 mitochondrially encoded cytochrome c oxidase II Homo sapiens 26-31 10977130-1 2000 The purpose of this study was to assess the selectivity and potency of the nonsteroidal anti-inflammatory drug (NSAID), flurbiprofen, and its enantiomers in their inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Flurbiprofen 120-132 mitochondrially encoded cytochrome c oxidase II Homo sapiens 224-229 10977130-5 2000 The selectivity for COX-1 vs. COX-2, expressed as the reciprocal ratio of the IC50, was 32 for racemic, 16 for S(+), and 5.3 for R(-) flurbiprofen. Flurbiprofen 129-146 mitochondrially encoded cytochrome c oxidase II Homo sapiens 30-35 10780769-10 2000 The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin. Flurbiprofen 115-127 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-9 10780769-10 2000 The COX 2:COX 1 selectivity ratio (COX 2 IC50/COX I IC50) was <0.0001 for nimesulide, 0.001 for NS398, 0.03 for flurbiprofen and 1.9 for indomethacin. Flurbiprofen 115-127 mitochondrially encoded cytochrome c oxidase II Homo sapiens 35-40 11112151-3 2000 Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression. Flurbiprofen 67-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 150-155 11112151-3 2000 Inhibition of PGE(2) production with a nonselective COX inhibitor (flurbiprofen, 10 microM) resulted in a significant reduction in IL-1 beta- induced COX-2 expression, supporting a role of endogenous COX metabolites in the modulation of COX-2 expression. Flurbiprofen 67-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 237-242 10977131-8 2000 The selectivity of S(+) flurbiprofen for inhibition of COX-1 was expressed as the ratio of IC50 for COX-2/COX-1. Flurbiprofen 20-36 mitochondrially encoded cytochrome c oxidase II Homo sapiens 100-105 10977131-12 2000 S(+) flurbiprofen inhibited PGE2 production of untreated tissue homogenates at an IC50 of 8 x 10(-10) M whereas, in the stimulated tissue, IC50 was found to be 3 x 10(-6) M. The selectivity of S(+) flurbiprofen for inhibition of constitutively present COX-1, relative to the inhibition of induced COX-2, was 3,600. Flurbiprofen 1-17 mitochondrially encoded cytochrome c oxidase II Homo sapiens 297-302 10091674-1 1999 Comparative computer modeling of the X-ray crystal structures of cyclooxygenase isoforms COX-1 and COX-2 has led to the design of COX-2 selectivity into the nonselective inhibitor flurbiprofen. Flurbiprofen 180-192 mitochondrially encoded cytochrome c oxidase II Homo sapiens 99-104 10091674-1 1999 Comparative computer modeling of the X-ray crystal structures of cyclooxygenase isoforms COX-1 and COX-2 has led to the design of COX-2 selectivity into the nonselective inhibitor flurbiprofen. Flurbiprofen 180-192 mitochondrially encoded cytochrome c oxidase II Homo sapiens 130-135 10091674-2 1999 The COX-2 modeling was based on a postulated binding mode for flurbiprofen and took advantage of a small alcove in the COX-2 active site created by different positions of the Leu384 sidechain between COX-1 and COX-2. Flurbiprofen 62-74 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-9 10091674-3 1999 The design hypothesis was tested by synthesis and biological assay of a series of flurbiprofen analogs, culminating in the discovery of several inhibitors having up to 78-fold selectivity for COX-2 over COX-1. Flurbiprofen 82-94 mitochondrially encoded cytochrome c oxidase II Homo sapiens 192-197 7864817-5 1995 NS-398, flurbiprofen, meclofenamic acid and indomethacin are time-dependent, irreversible inhibitors of hCox-2. Flurbiprofen 8-20 mitochondrially encoded cytochrome c oxidase II Homo sapiens 104-110 8226870-7 1993 Both immunoprecipitated Cox-1 and Cox-2 possessed cyclooxygenase activity that was inhibited by flurbiprofen. Flurbiprofen 96-108 mitochondrially encoded cytochrome c oxidase II Homo sapiens 34-39 9099957-9 1997 The non-steroidal anti-inflammatory drug flurbiprofen (5 microM), in the presence of exogenous dmPGE2, inhibited the up-regulation of COX-2 mRNA and PC-3 cell growth. Flurbiprofen 41-53 mitochondrially encoded cytochrome c oxidase II Homo sapiens 134-139 8809635-1 1996 The stereoselective inhibition of inducible cyclooxygenase (COX-2) by chiral nonsteroidal antiinflammatory drugs (NSAIDs)--ketoprofen, flurbiprofen, and ketorolac--has been investigated. Flurbiprofen 135-147 mitochondrially encoded cytochrome c oxidase II Homo sapiens 60-65 32934701-0 2020 Flurbiprofen suppresses the inflammation, proliferation, invasion and migration of colorectal cancer cells via COX2. Flurbiprofen 0-12 mitochondrially encoded cytochrome c oxidase II Homo sapiens 111-115 32934701-5 2020 Subsequently, COX2 expression affected by flurbiprofen was tested using western blotting, reverse transcription-quantitative PCR and immunofluorescence. Flurbiprofen 42-54 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-18 32934701-11 2020 Furthermore, it was identified that flurbiprofen inhibited the expression of COX2. Flurbiprofen 36-48 mitochondrially encoded cytochrome c oxidase II Homo sapiens 77-81 32934701-12 2020 Notably, flurbiprofen suppressed the expression of inflammatory factors by inhibiting COX2. Flurbiprofen 9-21 mitochondrially encoded cytochrome c oxidase II Homo sapiens 86-90 32934701-13 2020 Moreover, flurbiprofen inhibited the proliferation, invasion and migration of colorectal cancer cells by inhibiting COX2. Flurbiprofen 10-22 mitochondrially encoded cytochrome c oxidase II Homo sapiens 116-120 32934701-14 2020 In conclusion, the present study revealed that flurbiprofen inhibited COX2 expression in colorectal cancer, and affected the proliferation, invasion, migration and apoptosis of colorectal cancer cells. Flurbiprofen 47-59 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-74 32934701-15 2020 These results expand the understanding of the function of COX2 in colorectal cancer and the effect of flurbiprofen on COX2 expression. Flurbiprofen 102-114 mitochondrially encoded cytochrome c oxidase II Homo sapiens 118-122