PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8631960-7 1996 The KI values associated with the formation of the first reversible complex (EI) for flurbiprofen with PGHS1 and PGHS2 were 0.53 +/- 0. Flurbiprofen 85-97 prostaglandin-endoperoxide synthase 1 Homo sapiens 103-108 8652509-2 1996 The X-ray crystal structures of PGHS-1 in complex with the NSAIDs flurbiprofen and bromoaspirin have been determined previously [Picot, D., et al. Flurbiprofen 66-78 prostaglandin-endoperoxide synthase 1 Homo sapiens 32-38 8626626-1 1996 Previous studies of the crystal structure of the ovine prostaglandin endoperoxide H synthase-1 (PGHS-1)/S-flurbiprofen complex (Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249) suggest that the enzyme is associated with membranes through a series of four amphipathic helices located between residues 70 and 117. Flurbiprofen 106-118 prostaglandin-endoperoxide synthase 1 Homo sapiens 55-94 8626626-1 1996 Previous studies of the crystal structure of the ovine prostaglandin endoperoxide H synthase-1 (PGHS-1)/S-flurbiprofen complex (Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249) suggest that the enzyme is associated with membranes through a series of four amphipathic helices located between residues 70 and 117. Flurbiprofen 106-118 prostaglandin-endoperoxide synthase 1 Homo sapiens 96-102 8631960-11 1996 These results show that the overall affinity for the inhibition of PGHS1 versus PGHS2 was 30-fold greater for indomethacin (KI* = 0.032 +/- 0.005 and 1.02 +/- 0.08 microM, respectively) and 3-fold greater for flurbiprofen (KI* = 0.017 +/- 0.002 and 0.045 +/- 0.004 microM, respectively). Flurbiprofen 209-221 prostaglandin-endoperoxide synthase 1 Homo sapiens 67-72 8631960-12 1996 The results also show that for both PGHS1 and PGHS2, flurbiprofen was bound tighter to the initial EI complex than indomethacin; however, the rate of dissociation from EI* was slower for indomethacin than flurbiprofen. Flurbiprofen 53-65 prostaglandin-endoperoxide synthase 1 Homo sapiens 36-41 11318639-5 2001 We present here crystal structures of prostaglandin H(2) synthase-1 in complex with the inhibitors ibuprofen, methyl flurbiprofen, flurbiprofen, and alclofenac at resolutions ranging from 2.6 to 2.75 A. Flurbiprofen 117-129 prostaglandin-endoperoxide synthase 1 Homo sapiens 38-67 10977130-1 2000 The purpose of this study was to assess the selectivity and potency of the nonsteroidal anti-inflammatory drug (NSAID), flurbiprofen, and its enantiomers in their inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Flurbiprofen 120-132 prostaglandin-endoperoxide synthase 1 Homo sapiens 177-193 10977131-0 2000 Constitutive cyclooxygenase-1 and induced cyclooxygenase-2 in isolated human iris inhibited by S(+) flurbiprofen. Flurbiprofen 95-112 prostaglandin-endoperoxide synthase 1 Homo sapiens 13-29 8982652-2 1996 In whole blood, flurbiprofen was approximately 10-fold more potent that flurbinitroxybutylester to inhibit the cyclooxygenase activity of platelet prostaglandin endoperoxide synthase-1 (IC50 microM: 0.90 +/- 0.27 vs. 10.70 +/- 5, mean +/- S.D., P < 0.05). Flurbiprofen 16-28 prostaglandin-endoperoxide synthase 1 Homo sapiens 147-184 8982652-5 1996 In whole blood, flurbinitroxybutylester was slowly converted to flubiprofen and this in turn could influence the extent of inhibition of the cyclooxygenase activity of prostaglandin endoperoxide synthase-1. Flurbiprofen 64-75 prostaglandin-endoperoxide synthase 1 Homo sapiens 168-205 8982652-6 1996 In conclusion, the addition of a nitroxybutyl moiety to flurbiprofen seems to reduce its capacity to inhibit the cyclooxygenase activity of prostaglandin endoperoxide synthase-1. Flurbiprofen 56-68 prostaglandin-endoperoxide synthase 1 Homo sapiens 140-177 7965814-6 1994 Indomethacin, flurbiprofen, meclofenamate and diclofenac, but not ibuprofen, piroxicam or phenylbutazone, caused time-dependent inhibition of both hPGHS-1 and -2 in vitro. Flurbiprofen 14-26 prostaglandin-endoperoxide synthase 1 Homo sapiens 147-161 7965814-7 1994 For cells pretreated with flurbiprofen or meclofenamate, hPGHS-2 activities, but not hPGHS-1 activities, were recovered relatively rapidly; with indomethacin, recoveries of hPGHS-1 and hPGHS-2 activities were both slow. Flurbiprofen 26-38 prostaglandin-endoperoxide synthase 1 Homo sapiens 85-92 7965814-7 1994 For cells pretreated with flurbiprofen or meclofenamate, hPGHS-2 activities, but not hPGHS-1 activities, were recovered relatively rapidly; with indomethacin, recoveries of hPGHS-1 and hPGHS-2 activities were both slow. Flurbiprofen 26-38 prostaglandin-endoperoxide synthase 1 Homo sapiens 173-180 12711844-1 2003 In homogenates of the human iris, the nonsteroidal anti-inflammatory drug (NSAID) S(+)flurbiprofen has been reported to inhibit cyclooxygenase-1 (COX-1) 70-fold more potently than in human whole blood. Flurbiprofen 83-98 prostaglandin-endoperoxide synthase 1 Homo sapiens 128-144 15892673-4 2005 Non-selective cyclooxygenase-1 (COX-1) inhibitors used in periodontal research include compounds such as aspirin, flurbiprofen, ibuprofen, naproxen and piroxicam. Flurbiprofen 114-126 prostaglandin-endoperoxide synthase 1 Homo sapiens 14-30 14672659-3 2004 We present here the 2.0 A resolution X-ray crystal structure of ovine prostaglandin H2 synthase-1 in complex with alpha-methyl-4-biphenylacetic acid, a defluorinated analog of the non-steroidal anti-inflammatory drug flurbiprofen. Flurbiprofen 217-229 prostaglandin-endoperoxide synthase 1 Homo sapiens 70-97 12711844-1 2003 In homogenates of the human iris, the nonsteroidal anti-inflammatory drug (NSAID) S(+)flurbiprofen has been reported to inhibit cyclooxygenase-1 (COX-1) 70-fold more potently than in human whole blood. Flurbiprofen 83-98 prostaglandin-endoperoxide synthase 1 Homo sapiens 146-151 12711844-4 2003 Therefore, we conclude that the difference in IC(50) values of S(+)flurbiprofen towards COX-1 in the human iris and human whole blood is not related to differences in the occurrence of spliced COX-1. Flurbiprofen 64-79 prostaglandin-endoperoxide synthase 1 Homo sapiens 88-93 12451314-3 2002 The selective cyclooxygenase-1 inhibitor flurbiprofen, but not by the cyclooxygenase-2 inhibitor L-745337, prevented the contractile effect of both C5a and Ac-YSFKPMPLaR. Flurbiprofen 41-53 prostaglandin-endoperoxide synthase 1 Homo sapiens 14-30