PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7694037-11 1993 In patients with cbl C and cbl D mutations, methionine levels remained low or low-normal at 8.3 to 15.6 mumol/L (normal, 13.3 to 42.7) despite betaine treatment. Betaine 143-150 Cbl proto-oncogene Homo sapiens 17-20 7694037-12 1993 We conclude that (1) betaine levels are maintained in most patients with Cbl and folate deficiency; (2) levels of N,N-dimethylglycine and N-methylglycine are increased in most patients with folate deficiency; and (3) betaine therapy is relatively ineffective in patients with defective synthesis of CH3-Cbl. Betaine 21-28 Cbl proto-oncogene Homo sapiens 73-76