PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26213999-1 2015 Betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 convert homocysteine to methionine using betaine and S-methylmethionine, respectively, as methyl donor substrates. Betaine 99-106 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 33975330-4 2021 We have also shown that betaine increases histone methyltransferase activity by activating chromatin bound betaine homocysteine S-methyltransferase (BHMT). Betaine 24-31 betaine--homocysteine S-methyltransferase Homo sapiens 149-153 32939549-8 2020 RESULTS: The candidate SNP BHMT R239Q (rs3733890) was associated with lower concentrations of plasma betaine and DMG concentrations (-4.00% and -6.75% per variant allele, respectively; both nominal P < 0.05). Betaine 101-108 betaine--homocysteine S-methyltransferase Homo sapiens 27-31 32096676-5 2020 We show that the methyl donor betaine and the betaine homocysteine methyltransferase (BHMT) enzyme can act in the nucleus to repair epigenetic control and activate neuroprotective transcriptional programs. Betaine 30-37 betaine--homocysteine S-methyltransferase Homo sapiens 86-90 30746538-1 2019 Betaine is a methyl donor utilized in regeneration of methionine from homocysteine in a metabolic reaction catalyzed by betaine-homocysteine methyltransferase (BHMT), an enzyme mostly localized in the liver. Betaine 0-7 betaine--homocysteine S-methyltransferase Homo sapiens 120-158 30746538-1 2019 Betaine is a methyl donor utilized in regeneration of methionine from homocysteine in a metabolic reaction catalyzed by betaine-homocysteine methyltransferase (BHMT), an enzyme mostly localized in the liver. Betaine 0-7 betaine--homocysteine S-methyltransferase Homo sapiens 160-164 28468239-2 2017 Diet intake of choline can modulate methylation because, via betaine homocysteine methyltransferase (BHMT), this nutrient (and its metabolite, betaine) regulate the concentrations of S-adenosylhomocysteine and S-adenosylmethionine. Betaine 61-68 betaine--homocysteine S-methyltransferase Homo sapiens 101-105 26592251-1 2016 Betaine homocysteine methyltransferase (BHMT) catalyzes the synthesis of methionine using betaine and homocysteine (Hcy), which is restricted to the liver and kidney. Betaine 90-97 betaine--homocysteine S-methyltransferase Homo sapiens 0-38 26592251-1 2016 Betaine homocysteine methyltransferase (BHMT) catalyzes the synthesis of methionine using betaine and homocysteine (Hcy), which is restricted to the liver and kidney. Betaine 90-97 betaine--homocysteine S-methyltransferase Homo sapiens 40-44 26527363-3 2015 Concurrently, maternal betaine supplementation increased the plasma betaine concentration and muscle expression of methyl transfer enzymes (p < 0.05), BHMT and GNMT, in offspring piglets. Betaine 23-30 betaine--homocysteine S-methyltransferase Homo sapiens 154-158 26213999-1 2015 Betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 convert homocysteine to methionine using betaine and S-methylmethionine, respectively, as methyl donor substrates. Betaine 99-106 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 23727536-1 2013 Betaine-homocysteine S-methyltransferase (BHMT) is an important zinc-dependent methyltransferase that uses betaine as the methyl donor for the remethylation of homocysteine to form methionine. Betaine 107-114 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 25931143-10 2015 We further show that the mechanism of betaine protection was through BHMT-mediated catalysis. Betaine 38-45 betaine--homocysteine S-methyltransferase Homo sapiens 69-73 26182429-1 2015 Betaine is the substrate of the liver- and kidney-specific betaine-homocysteine (Hcy) methyltransferase (BHMT), an alternate pathway for Hcy remethylation. Betaine 0-7 betaine--homocysteine S-methyltransferase Homo sapiens 105-109 25466894-2 2015 The methyl donor S-adenosylmethionine (SAM) is produced in most cells through the folate cycle, but only a few cell types generate SAM from betaine (N,N,N-trimethylglycine) via betaine-homocysteine methyltransferase (BHMT), which is expressed in the mouse ICM. Betaine 140-147 betaine--homocysteine S-methyltransferase Homo sapiens 177-215 25466894-2 2015 The methyl donor S-adenosylmethionine (SAM) is produced in most cells through the folate cycle, but only a few cell types generate SAM from betaine (N,N,N-trimethylglycine) via betaine-homocysteine methyltransferase (BHMT), which is expressed in the mouse ICM. Betaine 149-171 betaine--homocysteine S-methyltransferase Homo sapiens 177-215 25466894-2 2015 The methyl donor S-adenosylmethionine (SAM) is produced in most cells through the folate cycle, but only a few cell types generate SAM from betaine (N,N,N-trimethylglycine) via betaine-homocysteine methyltransferase (BHMT), which is expressed in the mouse ICM. Betaine 149-171 betaine--homocysteine S-methyltransferase Homo sapiens 217-221 24795654-10 2014 Hepatocytes express high levels of both BGT1 and the only enzyme that can metabolize betaine, namely betaine:homocysteine -S-methyltransferase (BHMT1). Betaine 85-92 betaine--homocysteine S-methyltransferase Homo sapiens 101-142 24795654-10 2014 Hepatocytes express high levels of both BGT1 and the only enzyme that can metabolize betaine, namely betaine:homocysteine -S-methyltransferase (BHMT1). Betaine 85-92 betaine--homocysteine S-methyltransferase Homo sapiens 144-149 24795654-11 2014 The BHMT1 enzyme removes a methyl group from betaine and transfers it to homocysteine, a potential risk factor for cardiovascular disease. Betaine 45-52 betaine--homocysteine S-methyltransferase Homo sapiens 4-9 24895213-1 2014 Betaine-homocysteine S-methyltransferase (BHMT) is a zinc-dependent methyltransferase that uses betaine as the methyl donor for the remethylation of homocysteine to form methionine. Betaine 96-103 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 24895213-1 2014 Betaine-homocysteine S-methyltransferase (BHMT) is a zinc-dependent methyltransferase that uses betaine as the methyl donor for the remethylation of homocysteine to form methionine. Betaine 96-103 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 23727536-1 2013 Betaine-homocysteine S-methyltransferase (BHMT) is an important zinc-dependent methyltransferase that uses betaine as the methyl donor for the remethylation of homocysteine to form methionine. Betaine 107-114 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 22357209-1 2012 Betaine-homocysteine S-methyltransferase (BHMT) is an enzyme that converts homocysteine (Hcy) to methionine using betaine as a methyl donor. Betaine 114-121 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 23014492-3 2012 BHMT uses betaine as the methyl donor, whereas MS uses 5-methyltetrahydrofolate. Betaine 10-17 betaine--homocysteine S-methyltransferase Homo sapiens 0-4 22847001-3 2012 Another mechanism for AdoMet synthesis uses betaine as the methyl donor via the enzyme betaine-homocysteine methyltransferase (BHMT, EC 2.1.1.5), but it has been considered to be significant only in liver. Betaine 44-51 betaine--homocysteine S-methyltransferase Homo sapiens 87-125 23378610-8 2013 We identified four associations with three metabolites-glycine (rs715 at CPS1), serine (rs478093 at PHGDH), and betaine (rs499368 at SLC6A12; rs17823642 at BHMT)-and one association signal with glycine-to-serine ratio (rs1107366 at ALDH1L1). Betaine 112-119 betaine--homocysteine S-methyltransferase Homo sapiens 156-160 22847001-3 2012 Another mechanism for AdoMet synthesis uses betaine as the methyl donor via the enzyme betaine-homocysteine methyltransferase (BHMT, EC 2.1.1.5), but it has been considered to be significant only in liver. Betaine 44-51 betaine--homocysteine S-methyltransferase Homo sapiens 127-131 22357209-1 2012 Betaine-homocysteine S-methyltransferase (BHMT) is an enzyme that converts homocysteine (Hcy) to methionine using betaine as a methyl donor. Betaine 114-121 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 19534555-1 2009 Betaine-homocysteine S-methyltransferase (BHMT) catalyzes the transfer of a methyl group from betaine to l-homocysteine, yielding dimethylglycine and l-methionine. Betaine 94-101 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 21878621-6 2011 Bhmt(-/-) mice accumulated betaine in most tissues, including a 21-fold increase in the liver concentration compared with wild type (WT) (p < 0.01). Betaine 27-34 betaine--homocysteine S-methyltransferase Homo sapiens 0-4 19534555-1 2009 Betaine-homocysteine S-methyltransferase (BHMT) catalyzes the transfer of a methyl group from betaine to l-homocysteine, yielding dimethylglycine and l-methionine. Betaine 94-101 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 18230605-2 2008 Unlike the highly homologous betaine-homocysteine methyltransferase (BHMT), BHMT-2 cannot use betaine. Betaine 29-36 betaine--homocysteine S-methyltransferase Homo sapiens 69-73 18230605-7 2008 BHMT can use SMM as a methyl donor with a k(cat)/K(m) that is 5-fold lower than the k(cat)/K(m) for betaine. Betaine 100-107 betaine--homocysteine S-methyltransferase Homo sapiens 0-4 15122900-1 2004 Betaine-homocysteine S-methyltransferase (BHMT) is a zinc-dependent enzyme that catalyzes the transfer of a methyl group from glycine betaine (Bet) to homocysteine (Hcy) to form dimethylglycine (DMG) and methionine (Met). Betaine 126-141 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 16038618-1 2005 Betaine-homocysteine S-methyltransferase (BHMT) transfers a methyl group from betaine to Hcy to form DMG (dimethylglycine) and Met. Betaine 78-85 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 16038618-1 2005 Betaine-homocysteine S-methyltransferase (BHMT) transfers a methyl group from betaine to Hcy to form DMG (dimethylglycine) and Met. Betaine 78-85 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 16038618-3 2005 Using intrinsic tryptophan fluorescence [Castro, Gratson, Evans, Jiracek, Collinsova, Ludwig and Garrow (2004) Biochemistry 43, 5341-5351], it was shown that BHMT exists in three steady-state conformations: enzyme alone, enzyme plus occupancy at the first substrate-binding site (Hcy or Met), or enzyme plus occupancy at both substrate-binding sites (Hcy plus betaine, or Hcy plus DMG). Betaine 360-367 betaine--homocysteine S-methyltransferase Homo sapiens 158-162 15122900-1 2004 Betaine-homocysteine S-methyltransferase (BHMT) is a zinc-dependent enzyme that catalyzes the transfer of a methyl group from glycine betaine (Bet) to homocysteine (Hcy) to form dimethylglycine (DMG) and methionine (Met). Betaine 126-141 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 12220488-1 2002 Betaine-homocysteine methyl transferase (BHMT) catalyzes the synthesis of methionine from betaine and homocysteine (Hcy), utilizing a zinc ion to activate Hcy. Betaine 90-97 betaine--homocysteine S-methyltransferase Homo sapiens 0-39 12818402-2 2003 Homocysteine remethylation to methionine is catalyzed by folate-dependent methionine synthase, or by betaine-homocysteine methyltransferase (BHMT), which utilizes betaine as the methyl donor. Betaine 101-108 betaine--homocysteine S-methyltransferase Homo sapiens 141-145 15006639-1 2004 Glycine betaine supplementation lowers homocysteine levels in homocystinuria and in chronic renal failure patients through methylation catalysed by betaine-homocysteine methyltransferase (BHMT). Betaine 0-15 betaine--homocysteine S-methyltransferase Homo sapiens 148-186 15006639-1 2004 Glycine betaine supplementation lowers homocysteine levels in homocystinuria and in chronic renal failure patients through methylation catalysed by betaine-homocysteine methyltransferase (BHMT). Betaine 0-15 betaine--homocysteine S-methyltransferase Homo sapiens 188-192 12220488-1 2002 Betaine-homocysteine methyl transferase (BHMT) catalyzes the synthesis of methionine from betaine and homocysteine (Hcy), utilizing a zinc ion to activate Hcy. Betaine 90-97 betaine--homocysteine S-methyltransferase Homo sapiens 41-45 11883905-1 2002 Betaine-homocysteine S-methyltransferase (BHMT; EC2.1.1.5) is a zinc metalloenzyme that catalyzes the transfer of a methyl group from betaine to homocysteine to produce dimethylglycine and Met, respectively. Betaine 134-141 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 11883905-1 2002 Betaine-homocysteine S-methyltransferase (BHMT; EC2.1.1.5) is a zinc metalloenzyme that catalyzes the transfer of a methyl group from betaine to homocysteine to produce dimethylglycine and Met, respectively. Betaine 134-141 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 11380830-2 2001 Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine (DMG). Betaine 137-139 betaine--homocysteine S-methyltransferase Homo sapiens 37-76 11380830-2 2001 Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine (DMG). Betaine 120-135 betaine--homocysteine S-methyltransferase Homo sapiens 37-76 11380830-2 2001 Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine (DMG). Betaine 120-135 betaine--homocysteine S-methyltransferase Homo sapiens 78-82 11380830-2 2001 Homocysteine metabolism is linked to betaine-homocysteine methyl transferase (BHMT), a zinc metalloenzyme that converts glycine betaine (GB) to N,N dimethylglycine (DMG). Betaine 137-139 betaine--homocysteine S-methyltransferase Homo sapiens 78-82 10987370-1 2000 In mammals, betaine of the mitochondrial matrix is used in the cytosol by betaine-homocysteine S-methyltransferase for methionine synthesis. Betaine 12-19 betaine--homocysteine S-methyltransferase Homo sapiens 74-114 11087663-3 2000 BHMT uses betaine, an intermediate of choline oxidation, as a methyl donor and is expressed primarily in the liver and kidney. Betaine 10-17 betaine--homocysteine S-methyltransferase Homo sapiens 0-4 10075673-9 1999 Similar to when betaine was added to a methionine-deficient diet, choline or sulfonium analogs of betaine induced BHMT expression. Betaine 16-23 betaine--homocysteine S-methyltransferase Homo sapiens 114-118 10529246-1 1999 Betaine-homocysteine S-methyltransferase (BHMT; EC 2.1.1.5) catalyzes the transfer of an N-methyl group from betaine to homocysteine to produce dimethylglycine and methionine, respectively. Betaine 109-116 betaine--homocysteine S-methyltransferase Homo sapiens 0-40 10529246-1 1999 Betaine-homocysteine S-methyltransferase (BHMT; EC 2.1.1.5) catalyzes the transfer of an N-methyl group from betaine to homocysteine to produce dimethylglycine and methionine, respectively. Betaine 109-116 betaine--homocysteine S-methyltransferase Homo sapiens 42-46 10075673-9 1999 Similar to when betaine was added to a methionine-deficient diet, choline or sulfonium analogs of betaine induced BHMT expression. Betaine 98-105 betaine--homocysteine S-methyltransferase Homo sapiens 114-118 8836329-3 1996 It has been shown that despite the inhibition of MS, the enhanced BHMT pathway utilizes hepatic betaine pools to maintain levels of SAM. Betaine 96-103 betaine--homocysteine S-methyltransferase Homo sapiens 66-70 8798461-1 1996 Porcine liver betaine-homocysteine methyltransferase (BHMT; EC) was purified to homogeneity, and the Michaelis constants for betaine, dimethylacetothetin, and L-homocysteine are 23, 155, and 32 microM, respectively. Betaine 14-21 betaine--homocysteine S-methyltransferase Homo sapiens 54-58