PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27183384-4	2016	A PEGylated form of CBS provided long-term stability and, when used in conjunction with the methylation agent betaine, dramatically increased survival in mice fed a normal diet.	Betaine	110-117	cystathionine beta-synthase	Mus musculus	20-23	
26231230-4	2016	Here, we have examined the effect of a betaine supplemented diet on the Tg-I278T Cbs (-/-) mouse model of CBS deficiency and compared its effectiveness to our previously published data using a methionine restricted diet.	Betaine	39-46	cystathionine beta-synthase	Mus musculus	81-84	
26231230-5	2016	Tg-I278T Cbs (-/-) mice on betaine, from the time of weaning until for 240 days of age, had a 40 % decrease in mean tHcy level and a 137 % increase in serum methionine levels.	Betaine	27-34	cystathionine beta-synthase	Mus musculus	9-12	
26231230-6	2016	Betaine-treated Tg-I278T Cbs (-/-) mice also exhibited increased levels of betaine-dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl-coenzyme A desaturase (SCD-1), and increased lipid droplet accumulation in the liver.	Betaine	0-7	cystathionine beta-synthase	Mus musculus	25-28	
26231230-7	2016	Betaine supplementation largely reversed the hair loss phenotype in Tg-I278T Cbs (-/-) animals, but was far less effective than methionine restriction in reversing the weight-loss, fat-loss, and osteoporosis phenotypes.	Betaine	0-7	cystathionine beta-synthase	Mus musculus	77-80	
26231230-8	2016	Surprisingly, betaine supplementation had several negative effects in control Tg-I278T Cbs (+/-) mice including decreased weight gain, lean mass, and bone mineral density.	Betaine	14-21	cystathionine beta-synthase	Mus musculus	87-90	
24730561-0	2014	Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse.	Betaine	65-72	cystathionine beta-synthase	Mus musculus	96-123	
22192524-0	2012	Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.	Betaine	10-17	cystathionine beta-synthase	Mus musculus	47-74	
20638882-5	2010	Betaine treatment did improve survival of cbs (-/-) mice and restored fertility to female cbs (-/-) mice but did so without significantly lowering Hcy levels.	Betaine	0-7	cystathionine beta-synthase	Mus musculus	42-45	
20638882-5	2010	Betaine treatment did improve survival of cbs (-/-) mice and restored fertility to female cbs (-/-) mice but did so without significantly lowering Hcy levels.	Betaine	0-7	cystathionine beta-synthase	Mus musculus	90-93