PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26404762-3 2016 Blocking HO-1 enzymatic activity by zinc protoporphyrin (ZnPP) augmented arsenic-induced apoptosis, ROS production and mitochondrial dysfunction, suggesting a critical role for HO-1 as a renal protectant in this procession. ros 100-103 heme oxygenase 1 Homo sapiens 9-13 26404762-4 2016 On the other hand, TMP, upstream of HO-1, inhibited arsenic-induced ROS production and ROS-dependent HO-1 expression. ros 68-71 heme oxygenase 1 Homo sapiens 36-40 26404762-4 2016 On the other hand, TMP, upstream of HO-1, inhibited arsenic-induced ROS production and ROS-dependent HO-1 expression. ros 87-90 heme oxygenase 1 Homo sapiens 36-40 26404762-4 2016 On the other hand, TMP, upstream of HO-1, inhibited arsenic-induced ROS production and ROS-dependent HO-1 expression. ros 87-90 heme oxygenase 1 Homo sapiens 101-105 26404762-6 2016 Our results revealed that the regulation of arsenic-induced HO-1 expression was performed through multiple ROS-dependent signal pathways and the corresponding transcription factors, including p38 MAPK and JNK (but not ERK), AP-1, Nrf2 and NF-kappaB. ros 107-110 heme oxygenase 1 Homo sapiens 60-64 26795735-8 2016 TrxR was shown to regulate HO-1 via the Nrf2 signaling pathway in a ROS-dependent manner. ros 68-71 heme oxygenase 1 Homo sapiens 27-31 26681956-2 2016 To examine the mechanisms by which this occurs, we hypothesized that an increase in heme oxygenase 1, a potent antioxidant gene, will decrease uric acid levels and adipocyte dysfunction via suppression of ROS and xanthine oxidase (XO) levels. ros 205-208 heme oxygenase 1 Homo sapiens 84-100 26801320-2 2016 In this research we proved that cisplatin induced cell injuries and heme oxygenase-1 (HO-1) expression in laryngeal squamous cell cancer Hep-2 cells through ROS generation. ros 157-160 heme oxygenase 1 Homo sapiens 68-84 26801320-2 2016 In this research we proved that cisplatin induced cell injuries and heme oxygenase-1 (HO-1) expression in laryngeal squamous cell cancer Hep-2 cells through ROS generation. ros 157-160 heme oxygenase 1 Homo sapiens 86-90 26801320-3 2016 The induction of HO-1 clearly protected Hep-2 cells from cisplatin-induced cell death and ROS reaction, and the inhibitor of HO-1 enhanced the cell death and ROS generation induced by cisplatin. ros 90-93 heme oxygenase 1 Homo sapiens 17-21 26801320-3 2016 The induction of HO-1 clearly protected Hep-2 cells from cisplatin-induced cell death and ROS reaction, and the inhibitor of HO-1 enhanced the cell death and ROS generation induced by cisplatin. ros 158-161 heme oxygenase 1 Homo sapiens 125-129 25615876-3 2015 The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs. ros 208-211 heme oxygenase 1 Homo sapiens 51-67 25615876-3 2015 The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs. ros 208-211 heme oxygenase 1 Homo sapiens 69-73 25615876-4 2015 Moreover, the inhibition of HO-1 expression by tin porphyrin (SnPP) abolished the protective effects of pPolyHb, which suggested that the cytoprotective effect of pPolyHb involves upregulating HO-1 and subsequently decreasing the phosphorylation of the JNK and p38 MAPK and ROS generation. ros 274-277 heme oxygenase 1 Homo sapiens 28-32 26078725-10 2015 ROS scavenger N-acetyl-L-cysteine (NAC) blocked the autophagy process induced by 5cGy alpha particle, the upregulation of Nrf2 and HO-1, as well as the induced radio-resistance. ros 0-3 heme oxygenase 1 Homo sapiens 131-135 26078725-11 2015 In conclusion, ROS elevation caused by LDIR promoted Autophagy/Nrf2-HO-1 and conferred radio-resistance in A549. ros 15-18 heme oxygenase 1 Homo sapiens 68-72 25835394-5 2015 CE induced the expression of HO-1 as well as C-reactive protein (CRP) and NADPH oxidase 4 (NOX4), which are associated with ROS production. ros 124-127 heme oxygenase 1 Homo sapiens 29-33 25795137-7 2015 Excess intracellular ROS induced by Dex significantly suppressed the expression levels of Nrf2 and the downstream effectors, HO1 and NQO1, but these changes could be reversed by I3C. ros 21-24 heme oxygenase 1 Homo sapiens 125-128 25620054-7 2015 Inhibition of HO-1 enzymatic activity with SnPPIX and silencing of the HO-1 gene by siRNA enhanced DEP-induced ROS production, further decreased cell viability and increased expression of inflammatory and cell adhesion molecules. ros 111-114 heme oxygenase 1 Homo sapiens 14-18 25620054-7 2015 Inhibition of HO-1 enzymatic activity with SnPPIX and silencing of the HO-1 gene by siRNA enhanced DEP-induced ROS production, further decreased cell viability and increased expression of inflammatory and cell adhesion molecules. ros 111-114 heme oxygenase 1 Homo sapiens 71-75 25620054-8 2015 On the other hand, overexpression of the HO-1 gene by a pcDNA 3.1D/V5-HO-1 plasmid significantly mitigated ROS production, increased cell survival and decreased the expression of inflammatory genes. ros 107-110 heme oxygenase 1 Homo sapiens 41-45 25620054-8 2015 On the other hand, overexpression of the HO-1 gene by a pcDNA 3.1D/V5-HO-1 plasmid significantly mitigated ROS production, increased cell survival and decreased the expression of inflammatory genes. ros 107-110 heme oxygenase 1 Homo sapiens 70-74 25835394-9 2015 Treatment with carbon monoxide releasing molecule-2 (CORM-2) significantly inhibited CE-induced ROS production, while the addition of HO-1 inhibitor, significantly increased CE-induced ROS production and apoptosis, suggesting a protective role of HO-1 or its reaction product, CO, in CE-induced apoptosis. ros 185-188 heme oxygenase 1 Homo sapiens 134-138 21833623-7 2011 Our results indicated that HO-1 counteracts oxidative imbalance reducing ROS levels. ros 73-76 heme oxygenase 1 Homo sapiens 27-31 21327864-2 2011 In this study we showed that ATO induced cell damage and heme oxygenase-1 (HO-1) expression in glioma cells via ROS generation. ros 112-115 heme oxygenase 1 Homo sapiens 75-79 21327864-3 2011 HO-1 inducer clearly protected from ATO-induced cell death and ROS generation, and HO-1 inhibitor led to a significant increase in cell death and ROS generation induced by ATO. ros 63-66 heme oxygenase 1 Homo sapiens 0-4 21327864-3 2011 HO-1 inducer clearly protected from ATO-induced cell death and ROS generation, and HO-1 inhibitor led to a significant increase in cell death and ROS generation induced by ATO. ros 146-149 heme oxygenase 1 Homo sapiens 83-87 18769232-3 2008 RECENT FINDINGS: Heme oxygenase-1 has been shown to be protective against atherosclerosis via decreasing ROS generation and proinflammatory cytokine production resulting in diminished lipid uptake and foam cell formation. ros 105-108 heme oxygenase 1 Homo sapiens 17-33 20188821-8 2010 These results demonstrate that CSPE-induced ROS generation is mediated through a c-Src/NADPH oxidase/MAPK pathway and in turn initiates the activation of Nrf2 and ultimately induces HO-1 expression in HTSMCs. ros 44-47 heme oxygenase 1 Homo sapiens 182-186 20193368-10 2009 CONCLUSION: ROS only partly mediated HO-1; expression in the TNF-alpha-stimulated HUVEC; alpha-ZAL has a potent inhibitory effect on the HO-1 expression and cytosolic free calcium level in the TNF-alpha-stimulated HUVEC, mainly through the inhibition of ROS generation derived from NADPH oxidase. ros 12-15 heme oxygenase 1 Homo sapiens 37-41 20193368-10 2009 CONCLUSION: ROS only partly mediated HO-1; expression in the TNF-alpha-stimulated HUVEC; alpha-ZAL has a potent inhibitory effect on the HO-1 expression and cytosolic free calcium level in the TNF-alpha-stimulated HUVEC, mainly through the inhibition of ROS generation derived from NADPH oxidase. ros 12-15 heme oxygenase 1 Homo sapiens 137-141 18996220-5 2009 ROS-mediated DNA damage as measured by the presence of 8-OHdG DNA-adducts in their nuclei, IkappaB phosphorylation, NF-kappaB activation and increases in c-Myc and HO-1 protein levels were also observed, suggesting that these factors play a relevant role in the arsenite induced MCF-7 cell recruitment into the S-phase of the cell cycle and cell proliferation observed. ros 0-3 heme oxygenase 1 Homo sapiens 164-168 21414301-0 2011 Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells. ros 57-60 heme oxygenase 1 Homo sapiens 32-48 21414301-3 2011 In HaCaT cells, celastrol-induced HO-1 expression was dependent on ROS generation. ros 67-70 heme oxygenase 1 Homo sapiens 34-38 21414301-9 2011 Taken together, our results indicate that celastrol can activate the ROS-ERK/p38-Nrf2-ARE signaling cascades leading to the up-regulation of HO-1 which is partly responsible for its anti-inflammatory activity in the keratinocytes. ros 69-72 heme oxygenase 1 Homo sapiens 141-145 18593583-5 2008 These results suggest that regulation of the anti-oxidant enzyme HO-1 via the PI3K and p38/Nrf2 signaling pathways controls the intracellular levels of ROS. ros 152-155 heme oxygenase 1 Homo sapiens 65-69 34906793-7 2022 Our study revealed that m-beta-CoV upregulated Park7, RelA, Nrf2, and Hmox1 transcripts involved in ROS production and antioxidant pathways, describing the possible nexus between oxidative pathways, MMPs, and TIMP in m-beta-CoV-induced neuroinflammation. ros 100-103 heme oxygenase 1 Homo sapiens 70-75 15876423-11 2005 These data suggest that induction of HO-1 protein may participate in the protective mechanism of QE on oxidative stress (H(2)O(2))-induced apoptosis, and reduction of intracellular ROS production and mitochondria dysfunction with blocking apoptotic events were involved. ros 181-184 heme oxygenase 1 Homo sapiens 37-41 15773552-3 2005 In this study we have examined, whether the scavenging of reactive oxygen and reactive nitrogen species (ROS and RNS) is the major cause for thiol-mediated suppression of the HOX-1 induction by NO. ros 105-108 heme oxygenase 1 Homo sapiens 175-180 18006113-7 2008 Pharmacologic suppression of HO-1 activity resulted in a marked increase in the ROS generation in cisplatin-treated cells. ros 80-83 heme oxygenase 1 Homo sapiens 29-33 15773552-4 2005 Further, to identify the ROS family members implicated in the HOX-1 induction, we also exposed cells to various non-thiol antioxidants: dimethyl sulfoxide, dimetylthiourea, sodium salicylate, sodium formate, uric acid, catalase, and superoxide dismutase. ros 25-28 heme oxygenase 1 Homo sapiens 62-67 14660625-11 2004 Heme oxygenase-1 expression was increased in rho(0) cells, and a heme oxygenase-1 inhibitor decreased the induction of MnSOD in rho(0) cells and their resistance against ROS donors. ros 170-173 heme oxygenase 1 Homo sapiens 0-16 14660625-11 2004 Heme oxygenase-1 expression was increased in rho(0) cells, and a heme oxygenase-1 inhibitor decreased the induction of MnSOD in rho(0) cells and their resistance against ROS donors. ros 170-173 heme oxygenase 1 Homo sapiens 65-81 34964128-15 2021 Summarily, C3G exerted a protective effect on ROS-mediated cellular damage in HNPCs under HG condition, which was attributed to the induction of the Nrf2/HO-1 signaling pathway. ros 46-49 heme oxygenase 1 Homo sapiens 154-158 34508760-9 2021 More importantly, HMOX1 knockdown attenuated Fe2+ overload, reduced iron content and ROS, and alleviated lipid peroxidation, which led to a reduction in ferroptosis in diabetic human endothelial cells. ros 85-88 heme oxygenase 1 Homo sapiens 18-23 33898397-8 2021 The mechanism experiments showed that the antitumor activity of ORI-NPs against breast cancer might be through ROS related Nrf2/HO-1 signaling pathway. ros 111-114 heme oxygenase 1 Homo sapiens 128-132 34688156-5 2021 Especially for malignant diseases, there may be new advances in the treatment of HO-1 by regulating abnormal ROS and metabolic signaling. ros 109-112 heme oxygenase 1 Homo sapiens 81-85 34190424-4 2021 BSO reduces intracellular glutathione levels to minimize ROS elimination and protein protection during PDT, and ZnPP inhibits the ROS-stimulated upregulation of the antioxidant HO-1, thus preventing ROS removal by cells after PDT. ros 130-133 heme oxygenase 1 Homo sapiens 177-181 34190424-4 2021 BSO reduces intracellular glutathione levels to minimize ROS elimination and protein protection during PDT, and ZnPP inhibits the ROS-stimulated upregulation of the antioxidant HO-1, thus preventing ROS removal by cells after PDT. ros 199-202 heme oxygenase 1 Homo sapiens 177-181 34217685-5 2021 Furthermore, it was demonstrated that luteolin promoted Nrf2 nuclear translocation, thereby increasing the expression of HO-1 that reduces ROS production, while the anti-pyroptotic effect of luteolin was reversed by a specific Nrf2 inhibitor. ros 139-142 heme oxygenase 1 Homo sapiens 121-125 35218740-10 2022 Taken together, the present study indicates that CORM-2-induced Nrf2/HO-1 alleviates IL-6/Jak2/Stat3-mediated inflammatory responses to Ang II by inhibiting NADPH oxidase- and mitochondria-derived ROS, suggesting that CORM-2 is a promising pharmacologic candidate to reverse the pathological changes involved in the inflammation of vessel wall for the prevention and treatment of AAA. ros 197-200 heme oxygenase 1 Homo sapiens 69-73 35286219-6 2022 Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner. ros 105-108 heme oxygenase 1 Homo sapiens 201-205 35286219-6 2022 Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner. ros 255-258 heme oxygenase 1 Homo sapiens 201-205 34822480-5 2021 The cytoprotective mechanism of these peptides involves an improvement in the cellular antioxidant defense system, as indicated by the suppression of the intracellular ROS generation through upregulation of the cytoprotective enzyme heme oxygenase-1. ros 168-171 heme oxygenase 1 Homo sapiens 233-249 34572050-3 2021 Subcellular traffics of HO-1 to different organelles constitute a network of interactions compromising a variety of effectors such as pro-oxidants, ROS, mitochondrial enzymes, and nucleic transcription factors. ros 148-151 heme oxygenase 1 Homo sapiens 24-28 35472411-3 2022 There is a significant body of research investigating the effects of oxidative stress/ROS on ASM behaviour, falling into the following categories; cigarette smoke and associated compounds, air pollutants, aero-allergens, asthma and COPD relevant mediators, and the anti-oxidant Nrf2/HO-1 signalling pathway. ros 86-89 heme oxygenase 1 Homo sapiens 283-287 35144642-8 2022 Activated ROS-metabolism was identified in METTL7B-overexpressed LUAD cells, accompanied with upregulated protein level of GPX4, HMOX1 and SOD1 and their enzymatic activities. ros 10-13 heme oxygenase 1 Homo sapiens 129-134 30826469-4 2019 Moreover, Nrf2 translocation appeared both in GD 12.5 d and GD 18.5 d. In conclusion, DON-induced ROS accumulation may cause maternal liver damage in the initial stages, but the related stimulation of Nrf2/HO-1 pathway improves the removal of ROS and decreases the level of oxidative stress thereby protecting the liver damage. ros 243-246 heme oxygenase 1 Homo sapiens 206-210 32121588-1 2020 Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRalpha/PI3K/Akt/Nrf2/ARE axis in human pulmonary alveolar epithelial cells (HPAEpiCs). ros 98-101 heme oxygenase 1 Homo sapiens 53-74 32376267-0 2020 Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stress. ros 78-81 heme oxygenase 1 Homo sapiens 0-16 32509141-5 2020 Mechanistically, we showed that apatinib suppressed glutathione to generate ROS via the downregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and maintained an antitumor effect at a low level of VEGFR2 in ovarian cancer, suggesting that combination of apatinib with Nrf2 inhibitor may be a promising therapy strategy for patients with ovarian cancer. ros 76-79 heme oxygenase 1 Homo sapiens 161-177 32509141-5 2020 Mechanistically, we showed that apatinib suppressed glutathione to generate ROS via the downregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and maintained an antitumor effect at a low level of VEGFR2 in ovarian cancer, suggesting that combination of apatinib with Nrf2 inhibitor may be a promising therapy strategy for patients with ovarian cancer. ros 76-79 heme oxygenase 1 Homo sapiens 179-183 32124251-6 2020 Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes. ros 39-42 heme oxygenase 1 Homo sapiens 48-57 30826469-4 2019 Moreover, Nrf2 translocation appeared both in GD 12.5 d and GD 18.5 d. In conclusion, DON-induced ROS accumulation may cause maternal liver damage in the initial stages, but the related stimulation of Nrf2/HO-1 pathway improves the removal of ROS and decreases the level of oxidative stress thereby protecting the liver damage. ros 98-101 heme oxygenase 1 Homo sapiens 206-210 30041041-10 2018 Notably, activation of HO-1 gene expression further increased the levels of EETs, suggesting that the antioxidant HO-1 system protects EETs from degradation by ROS. ros 160-163 heme oxygenase 1 Homo sapiens 23-27 30736789-14 2019 CONCLUSIONS: These results indicate that STL or STB may induce GSK3beta-dependent cyclin D1 degradation, and increase HO-1 expression through activating Nrf2 via ROS-dependent p38 activation, which resulted in the decrease of the viability in SW480 cells. ros 162-165 heme oxygenase 1 Homo sapiens 118-122 30736789-13 2019 HO-1 expression by STL or STB resulted from Nrf2 activation through ROS-dependent p38 activation. ros 68-71 heme oxygenase 1 Homo sapiens 0-4 30041041-10 2018 Notably, activation of HO-1 gene expression further increased the levels of EETs, suggesting that the antioxidant HO-1 system protects EETs from degradation by ROS. ros 160-163 heme oxygenase 1 Homo sapiens 114-118 29753142-8 2018 Thereby, the antiviral activity of ROS/Nrf2/HO-1 axis was confirmed in EPC cells. ros 35-38 heme oxygenase 1 Homo sapiens 44-48 28598396-5 2017 At the same time Nrf2/HO-1 pathway is up-regulated by ROS to protect placenta cells from oxidative damage. ros 54-57 heme oxygenase 1 Homo sapiens 22-26 28598396-6 2017 In DON-treated BeWo cells, the level of ROS has time-effect and dose-effect relationships with HO-1 expression. ros 40-43 heme oxygenase 1 Homo sapiens 95-99 28694915-6 2017 Overall, our study is the first to demonstrate that the cytoprotective actions of halophenols involve their antiapoptotic, antioxidant, and anti-inflammatory abilities, which are mediated by the upregulation of Nrf2-dependent HO-1 expression and reductions in ROS and TNF-alpha generation via the activation of Erk1/2 and PI3K/Akt in EA.hy926 cells. ros 260-263 heme oxygenase 1 Homo sapiens 226-230 28255307-7 2017 Compared with MSC, MSC-HO-1 significantly attenuated H2O2-induced injury of RGC-5, including decrease in cellular ROS level and apoptosis, activation of antiapoptotic proteins p-Akt and Bcl-2, and blockage of proapoptotic proteins cleaved caspase 3 and Bax. ros 114-117 heme oxygenase 1 Homo sapiens 23-27 27782264-7 2016 Phase 2 enzymes in term of antioxidant response, such as heme oxygenase 1 (HMOX1) and the regulating subunit of the glutamate-cysteine ligase (GCLM) were slightly upregulated, but these observations may be linked solely to metal homeostasis disruptions, as these actors are involved in both metal and ROS responses. ros 301-304 heme oxygenase 1 Homo sapiens 57-73 27782264-7 2016 Phase 2 enzymes in term of antioxidant response, such as heme oxygenase 1 (HMOX1) and the regulating subunit of the glutamate-cysteine ligase (GCLM) were slightly upregulated, but these observations may be linked solely to metal homeostasis disruptions, as these actors are involved in both metal and ROS responses. ros 301-304 heme oxygenase 1 Homo sapiens 75-80