PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33939975-0 2021 A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways. ros 49-52 mitogen-activated protein kinase 1 Homo sapiens 103-106 34890707-8 2022 ROS and ROS/MAPK (Erk1/2, p38) functioned as the upstream signaling molecules in the activation of NF-kappaB and AP-1, respectively. ros 8-11 mitogen-activated protein kinase 1 Homo sapiens 26-29 34963561-4 2022 In addition, DNR induced NOX4-dependent ROS production, leading to the activation of p38 MAPK and inactivation of Akt and ERK. ros 40-43 mitogen-activated protein kinase 1 Homo sapiens 122-125 35204104-8 2022 UVB-induced ROS production mediated Akt and mitogen activated protein kinases (MAPKs) pathways, including p38, ERK, and JNK. ros 12-15 mitogen-activated protein kinase 1 Homo sapiens 111-114 35583119-5 2022 CNPs significantly increased the level of ROS to regulate ERK/JNK signaling, which would further induce resistant cell apoptosis. ros 42-45 mitogen-activated protein kinase 1 Homo sapiens 58-61 35616702-0 2022 Correction to: Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway. ros 136-139 mitogen-activated protein kinase 1 Homo sapiens 140-143 35185151-0 2022 Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma. ros 27-30 mitogen-activated protein kinase 1 Homo sapiens 68-71 34832853-6 2021 Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA-AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFkappaB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells. ros 60-63 mitogen-activated protein kinase 1 Homo sapiens 145-148 34580807-0 2021 Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation. ros 71-74 mitogen-activated protein kinase 1 Homo sapiens 84-87 35412176-0 2022 Duvira Antarctic polysaccharide inhibited H1N1 influenza virus-induced apoptosis through ROS mediated ERK and STAT-3 signaling pathway. ros 89-92 mitogen-activated protein kinase 1 Homo sapiens 102-105 34017584-0 2021 Erratum: Exosomes released by human umbilical cord mesenchymal stem cells protect against renal interstitial fibrosis through ROS-mediated P38MAPK/ERK signaling pathway. ros 126-129 mitogen-activated protein kinase 1 Homo sapiens 147-150 33364504-6 2020 ROS triggered JNK and ERK phosphorylation, and cyt c release outside mitochondria, not accompanied by caspases-9 and -3 activation, probably due to 3BP-dependent alkylation of cysteine residues at caspase-9 catalytic site. ros 0-3 mitogen-activated protein kinase 1 Homo sapiens 22-25 33638619-7 2021 By using MiR-27 mimic, we found it could increase ROS stress and apoptosis by down-regulating the expression of p-ERK/Nrf2 pathway by negatively regulating SPRY2. ros 50-53 mitogen-activated protein kinase 1 Homo sapiens 114-117 31301277-9 2019 The ROS scavenger NAC markedly diminished G2/M arrest, apoptosis, autophagy and activation of MAPK pathways induced by Rg5. ros 4-7 mitogen-activated protein kinase 1 Homo sapiens 94-98 33243299-0 2020 Correction to: Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells. ros 68-71 mitogen-activated protein kinase 1 Homo sapiens 90-93 33035517-10 2020 Moreover, morusin treatment strikingly enhanced intracellular ROS level, an ROS scavenger NAC blocked cell death and changes of Akt, JNK and ERK induced by morusin. ros 76-79 mitogen-activated protein kinase 1 Homo sapiens 141-144 32180468-8 2020 Moreover, the expression of p-Erk/Nrf2/Trx-signaling pathway proteins was also up-regulated and the generation of ROS was decreased after LIRA treatment which was inhibited after treatment with U0126 (Erk inhibitor). ros 114-117 mitogen-activated protein kinase 1 Homo sapiens 201-204 32994511-9 2020 Our study mechanistically demonstrates that ADMA is involved in the progression of kidney cell injury under high glucose condition by targeting coordinated complex mechanisms involving the NOX4- ROS-ERK pathway. ros 195-198 mitogen-activated protein kinase 1 Homo sapiens 199-202 33042402-0 2020 Exosomes released by human umbilical cord mesenchymal stem cells protect against renal interstitial fibrosis through ROS-mediated P38MAPK/ERK signaling pathway. ros 117-120 mitogen-activated protein kinase 1 Homo sapiens 138-141 32473481-5 2020 The resulted ROS could induce DNA damage of the tumor cells, thus enhancing the sensitivity to the inhibitor of NAMPT (FK866) to downregulate NAD/ERK/NF-kappaB signal pathways, and eventually simultaneously prevent cancer progression. ros 13-16 mitogen-activated protein kinase 1 Homo sapiens 146-149 31511637-0 2019 Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes. ros 72-75 mitogen-activated protein kinase 1 Homo sapiens 24-27 31301277-0 2019 Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer. ros 82-85 mitogen-activated protein kinase 1 Homo sapiens 95-99 32765093-8 2020 Conclusion: Altogether, the outcome of the study for the first time revealed that TN exhibited its potential chemotherapeutic effects through ROS-mediated ER stress-induced apoptosis via p38 and ERK MAPK signaling pathways. ros 142-145 mitogen-activated protein kinase 1 Homo sapiens 195-198 32698747-10 2020 We further demonstrated that apoptosis induction in HL-60 cells was mediated by increasing intracellular ROS levels via ERK but not p38 MAPKs pathway. ros 105-108 mitogen-activated protein kinase 1 Homo sapiens 120-123 31130519-4 2019 We determined that PAA covalently binds to the conserved cysteine site of peroxiredoxins I/II (Prxs-I/II) and inhibits their catalytic activity, subsequently activating the ROS/ERK axis and the immunogenicity of HCC toward NK cells. ros 173-176 mitogen-activated protein kinase 1 Homo sapiens 177-180 31776986-4 2019 This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways. ros 27-30 mitogen-activated protein kinase 1 Homo sapiens 93-96 30342220-7 2019 Together, inhibitions of PI3K/Akt and ERK and activation of p38 mediated the compounds-induced apoptosis through modulating the mitochondrial pathway and/or ROS production. ros 157-160 mitogen-activated protein kinase 1 Homo sapiens 38-41 30874538-8 2019 It seems that beta-Thujaplicin exerts these functions by ROS-mediated p38/ERK MAPK but not by JNK signaling pathway activation. ros 57-60 mitogen-activated protein kinase 1 Homo sapiens 74-77 30410328-8 2018 Moreover, Au-Ag@PDA NPs decreased the expression of phosphorylated AKT and ERK and promoted the production of ROS that function upstream of apoptosis and autophagy. ros 110-113 mitogen-activated protein kinase 1 Homo sapiens 75-78 30096402-4 2018 It was shown that the lactoferrin nanoparticle repolarized the tumor-associated macrophages from the M2 phenotype to M1 via regulating the STAT6 pathway, as well as induced the ROS-mediated mitochondrial apoptosis by inhibiting the Ras/Raf/p-Erk pathway in the glioma cells. ros 177-180 mitogen-activated protein kinase 1 Homo sapiens 242-245 29866132-9 2018 Mechanistically, the combined therapy significantly induced cancer cell apoptosis and autophagy, which were mediated by ROS regulated PKA and ERK signaling. ros 120-123 mitogen-activated protein kinase 1 Homo sapiens 142-145 29702094-0 2018 ROS mediated EGFR/MEK/ERK/HIF-1alpha Loop Regulates Glucose metabolism in pancreatic cancer. ros 0-3 mitogen-activated protein kinase 1 Homo sapiens 22-25 29702094-3 2018 The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop. ros 23-26 mitogen-activated protein kinase 1 Homo sapiens 45-48 29702094-3 2018 The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop. ros 23-26 mitogen-activated protein kinase 1 Homo sapiens 219-222 29702094-3 2018 The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop. ros 294-297 mitogen-activated protein kinase 1 Homo sapiens 45-48 29702094-3 2018 The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop. ros 294-297 mitogen-activated protein kinase 1 Homo sapiens 45-48 26472167-7 2016 Furthermore, ROS generation and subsequent activation of JNK and ERK might be involved in PM2.5 -induced apoptosis and G0/G1 phase arrest by downregulating Bcl-2/Bax protein ratio and upregulating p15INK4B , p16INK4A , and p21WAF1/CIP1 transcription level. ros 13-16 mitogen-activated protein kinase 1 Homo sapiens 65-68 28867437-5 2017 Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription. ros 37-40 mitogen-activated protein kinase 1 Homo sapiens 54-58 27748761-0 2017 Phosphorylation of cofilin-1 by ERK confers HDAC inhibitor resistance in hepatocellular carcinoma cells via decreased ROS-mediated mitochondria injury. ros 118-121 mitogen-activated protein kinase 1 Homo sapiens 32-35 28322340-7 2017 Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation. ros 49-52 mitogen-activated protein kinase 1 Homo sapiens 221-224 28295305-10 2018 Taken together, we found that DOX induced mitochondrial ROS release to activate ERK-mediated HSF2 nuclear translocation and AT1 R upregulation causing DOX-damaged heart failure in vitro and in vivo. ros 56-59 mitogen-activated protein kinase 1 Homo sapiens 80-83 29098529-0 2018 18beta-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-alpha/ERK pathway. ros 97-100 mitogen-activated protein kinase 1 Homo sapiens 111-114 29098529-6 2018 In conclusion, this study revealed that 18beta-GA inhibits migration and invasion via the ROS/PKC-alpha/ERK signaling pathway in gastric cancer cells. ros 90-93 mitogen-activated protein kinase 1 Homo sapiens 104-107 28443293-1 2017 This article contains data related to the article "Wogonin, a plant derived small molecule exerts potent anti-inflammatory and chondroprotective effects through activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes" (Khan et al. ros 175-178 mitogen-activated protein kinase 1 Homo sapiens 179-182 26472167-8 2016 In conclusion, our results indicate that ROS-JNK/ERK-apoptosis and G0/G1 arrest pathways are involved in PM2.5 -induced embryotoxicity, which not only provides insights into the molecular mechanism of PM2.5 -induced embryotoxicity, but also may help to identify specific interventions to improve adverse pregnancy outcomes of PM2.5 . ros 41-44 mitogen-activated protein kinase 1 Homo sapiens 49-52 26612416-8 2016 Moreover, Se@LDH-pooled siRNAs could induce cell apoptosis, change cell morphology and increase cellular ROS levels through change the expression of Bcl-2/Bax, activation of caspase-3, PI3K/AKT/mTOR and MAPK/ERK pathways. ros 105-108 mitogen-activated protein kinase 1 Homo sapiens 208-211 26715278-0 2016 ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway. ros 92-95 mitogen-activated protein kinase 1 Homo sapiens 83-86 26715278-7 2016 OA was shown to promote ERK-dependent Nrf2 expression in cancer cells, and in turn, Nrf2 expression was able to suppress OA-induced ROS generation. ros 132-135 mitogen-activated protein kinase 1 Homo sapiens 24-27 27392019-0 2016 Correction: Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation. ros 95-98 mitogen-activated protein kinase 1 Homo sapiens 109-112 26952810-4 2016 MIF-induced ROS led to ERK phosphorylation, which facilitated HMGB1 release from the nucleus to the cytoplasm. ros 12-15 mitogen-activated protein kinase 1 Homo sapiens 23-26 26715278-0 2016 ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway. ros 92-95 mitogen-activated protein kinase 1 Homo sapiens 0-3 26716417-7 2016 Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins. ros 130-133 mitogen-activated protein kinase 1 Homo sapiens 64-67 26716417-7 2016 Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins. ros 130-133 mitogen-activated protein kinase 1 Homo sapiens 148-151 26689473-3 2016 We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production. ros 153-156 mitogen-activated protein kinase 1 Homo sapiens 182-185 26689473-3 2016 We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production. ros 260-263 mitogen-activated protein kinase 1 Homo sapiens 182-185 26689473-4 2016 It remains to identify the link between ERK/Akt up-regulation and the consequent quenching effect on ROS intracellular level that efficiently and markedly delay the pro-apoptotic effect of the oxysterol. ros 101-104 mitogen-activated protein kinase 1 Homo sapiens 40-43 26465677-0 2015 A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway. ros 108-111 mitogen-activated protein kinase 1 Homo sapiens 112-115 26718128-6 2016 Taken together, our results indicated that hispolon suppressed the migration of breast cancer cells via suppressing the ROS/ERK/Slug/E-cadherin pathway. ros 120-123 mitogen-activated protein kinase 1 Homo sapiens 124-127 26086160-8 2015 Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway. ros 187-190 mitogen-activated protein kinase 1 Homo sapiens 95-98 26642060-8 2015 Molecular and cell biological studies demonstrated that HG increased ROS production, whereas treatment with bFGF or JNK/ERK inhibitors blocked HG-induced ROS accumulation. ros 154-157 mitogen-activated protein kinase 1 Homo sapiens 120-123 26642060-9 2015 Addition of MnTMPyP, a ROS scavenger, reduced HG-induced ROS production and accelerated cell migration, suggesting that the influence of HG on bFGF-MAPK signaling causes accumulation of ROS, which in turn regulate cell migration. ros 57-60 mitogen-activated protein kinase 1 Homo sapiens 148-152 26642060-9 2015 Addition of MnTMPyP, a ROS scavenger, reduced HG-induced ROS production and accelerated cell migration, suggesting that the influence of HG on bFGF-MAPK signaling causes accumulation of ROS, which in turn regulate cell migration. ros 57-60 mitogen-activated protein kinase 1 Homo sapiens 148-152 26086160-8 2015 Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway. ros 187-190 mitogen-activated protein kinase 1 Homo sapiens 107-111 26107995-7 2015 Interestingly, RuPOP@MWCNTs significantly enhanced the anticancer efficacy of clinically used X-ray against R-HepG2 cells through induction of apoptosis and G0/G1 cell cycle arrest, with the involvement of ROS overproduction, which activated several downstream signaling pathways, including DNA damage-mediated p53 phosphorylation, activation of p38, and inactivation of AKT and ERK. ros 206-209 mitogen-activated protein kinase 1 Homo sapiens 379-382 25650185-0 2015 FV-429 Induced Apoptosis Through ROS-Mediated ERK2 Nuclear Translocation and p53 Activation in Gastric Cancer Cells. ros 33-36 mitogen-activated protein kinase 1 Homo sapiens 46-50 26212545-0 2015 Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells. ros 67-70 mitogen-activated protein kinase 1 Homo sapiens 80-83 26212545-6 2015 Notably, we observed that sugiol interacted with transketolase, an enzyme in central metabolism, and increased ROS levels leading to the activation of ERK, which inhibits STAT3 activity. ros 111-114 mitogen-activated protein kinase 1 Homo sapiens 151-154 25065405-0 2014 Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation. ros 90-93 mitogen-activated protein kinase 1 Homo sapiens 94-97 25724548-0 2015 Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. ros 90-93 mitogen-activated protein kinase 1 Homo sapiens 94-97 25724548-6 2015 Specifically, we demonstrated that benzo[a]pyrene enhances breast cancer cell migration and invasion by up-regulating ROS-induced ERK signaling, leading to the activation of matrix metalloproteinases 9. ros 118-121 mitogen-activated protein kinase 1 Homo sapiens 130-133 25724548-7 2015 Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway. ros 197-200 mitogen-activated protein kinase 1 Homo sapiens 201-204 25776488-7 2015 Combination with PA and IR also increased the production of ROS, which subsequently induced phosphorylation of p38, suppressed phosphorylation of ERK, and activated caspase-3, -8, and -9. ros 60-63 mitogen-activated protein kinase 1 Homo sapiens 146-149 26089952-6 2015 High level of ROS was provoked by P2, which was in turn responsible for induction of apoptosis through activation of intrinsic mitochondrial pathway and JNK1/2, p38 MAPK pathways, as well as inhibition of ERK1/2 pathway, as evidenced by the abrogation of P2"s effect on HeLa cells preincubated with the ROS scavenger NAC. ros 14-17 mitogen-activated protein kinase 1 Homo sapiens 161-164 25135223-8 2014 Excessive ROS triggered DNA damage and activated downstream signaling pathways, including the phosphorylation of p53 and p38MAPK, and down-regulation of phosphorylated AKT and ERK, finally resulted in increase of radiosensitivity and inhibition of tumor reproduction. ros 10-13 mitogen-activated protein kinase 1 Homo sapiens 176-179 25684043-4 2015 Upon exposure to quinacrine, ROS-mediated p38 MAPK activation and ERK inactivation were observed in K562 cells. ros 29-32 mitogen-activated protein kinase 1 Homo sapiens 46-50 25044446-8 2014 Further, the effects of oxHDL for the enhanced formation of MMP-9 were found to be mediated by NADPH oxidase/ROS-JNK/ERK pathway, as one mechanism. ros 109-112 mitogen-activated protein kinase 1 Homo sapiens 117-120 25065405-9 2014 In addition, the activation of ROS-ERK pathway by mitochondrial fission induced phosphorylation of serine73 on MITF accelerating its proteasomal degradation. ros 31-34 mitogen-activated protein kinase 1 Homo sapiens 35-38 25065405-10 2014 In conclusion, mitochondrial dynamics may regulate melanogenesis by modulating ROS-ERK signaling pathway. ros 79-82 mitogen-activated protein kinase 1 Homo sapiens 83-86 25065405-3 2014 Here, we show that mitochondrial dynamics regulate melanogenesis by modulating the ROS-ERK signaling pathway. ros 83-86 mitogen-activated protein kinase 1 Homo sapiens 87-90 24122234-4 2014 Studies on amsacrine-treated U937 cells revealed that amsacrine-elicited ROS generation induced JNK and p38 MAPK activation but reduced the phospho-ERK level. ros 73-76 mitogen-activated protein kinase 1 Homo sapiens 148-151 24930757-0 2014 Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. ros 136-139 mitogen-activated protein kinase 1 Homo sapiens 140-143 24930757-10 2014 These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug. ros 132-135 mitogen-activated protein kinase 1 Homo sapiens 136-139 24122234-4 2014 Studies on amsacrine-treated U937 cells revealed that amsacrine-elicited ROS generation induced JNK and p38 MAPK activation but reduced the phospho-ERK level. ros 73-76 mitogen-activated protein kinase 1 Homo sapiens 108-112 23876460-8 2013 Collectively, these results suggest that Cd increases intracellular Ca2+ or ROS, which induces gamma-secretase-dependent N-cad/CTF2 production via the activation of the ERK signaling pathway in C6 glial cells. ros 76-79 mitogen-activated protein kinase 1 Homo sapiens 169-172 24555485-0 2014 Synergistic induction of apoptosis by methylseleninic acid and cisplatin, the role of ROS-ERK/AKT-p53 pathway. ros 86-89 mitogen-activated protein kinase 1 Homo sapiens 90-93 24586814-6 2014 Our results shown that TCHQ was more toxic than PCP and that a high dose of TCHQ led to necrotic cell death of the splenocytes through induction of massive and sudden ROS and prolonged ROS-triggered ERK activation. ros 185-188 mitogen-activated protein kinase 1 Homo sapiens 199-202 24586814-7 2014 Inhibition of ROS production by N-acetyl-cysteine (NAC) partially restored the mitochondrial membrane potential, inhibited ERK activity, elevated caspase-3 activity and PARP cleavage, and, eventually, switched the TCHQ-induced necrosis to apoptosis. ros 14-17 mitogen-activated protein kinase 1 Homo sapiens 123-126 24001789-0 2013 ZnO nanoparticles induce TNF-alpha expression via ROS-ERK-Egr-1 pathway in human keratinocytes. ros 50-53 mitogen-activated protein kinase 1 Homo sapiens 54-57 24001789-12 2013 CONCLUSIONS: The present study demonstrated that ZnO-NPs might induce inflammatory response via ROS-ERK-Egr-1 pathway in human keratinocytes. ros 96-99 mitogen-activated protein kinase 1 Homo sapiens 100-103 23696052-7 2013 In IGROV-1 cells 5F203-induced ROS formation was accompanied by JNK, ERK and P38MAPK phosphorylation, DNA damage and cell cycle arrest prior to apoptosis. ros 31-34 mitogen-activated protein kinase 1 Homo sapiens 69-72 23707387-2 2013 Caffeine induced an increase in the intracellular Ca(2+) concentration and ROS generation leading to p38 MAPK activation and ERK inactivation, respectively. ros 75-78 mitogen-activated protein kinase 1 Homo sapiens 125-128 23416140-8 2013 In conclusion, the JNK and p38 MAPK pathways might be critical mediators in CPF-induced neuronal apoptosis by both generating ROS and up-regulating COX-2. ros 126-129 mitogen-activated protein kinase 1 Homo sapiens 27-30 23353183-3 2013 Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation. ros 239-242 mitogen-activated protein kinase 1 Homo sapiens 20-23 23220614-10 2013 These results demonstrated for the first time that ISO induces apoptosis in HepG2 cells through inactivating ERK1/2 kinase and activating JNK and p38 kinases, and ROS stimulated by ISO is able to activate the MAPK singaling pathway as the upstream signaling molecules. ros 163-166 mitogen-activated protein kinase 1 Homo sapiens 146-149 23758151-0 2013 Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS-mediated MAPK pathways. ros 99-102 mitogen-activated protein kinase 1 Homo sapiens 112-116 23733672-0 2013 Surfactin-induced apoptosis through ROS-ERS-Ca2+-ERK pathways in HepG2 cells. ros 36-39 mitogen-activated protein kinase 1 Homo sapiens 49-52 23733672-7 2013 According to a comprehensive review of all the evidence, it is concluded that surfactin induces apoptosis of HepG2 cells through a ROS-ERS-Ca(2+) mediated ERK pathway. ros 131-134 mitogen-activated protein kinase 1 Homo sapiens 155-158 20432471-8 2010 Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway. ros 120-123 mitogen-activated protein kinase 1 Homo sapiens 148-151 21882190-9 2012 HG promoted phosphorylation of ERK1/2, JNK and p38 MAP kinases, which was abrogated by an ROS inhibitor. ros 90-93 mitogen-activated protein kinase 1 Homo sapiens 47-50 22288910-12 2012 Taken together, these results demonstrate that 2-ABP induces the carcinogenic factor COX-2 and that this induction is mediated through NADPH oxidase-derived ROS-dependent JNK/ERK-AP-1 pathways. ros 157-160 mitogen-activated protein kinase 1 Homo sapiens 175-178 22544998-3 2012 This oxidative stress response occurs in microglia through the activation of the ERK signaling pathway by proinflammatory stimuli, leading to the phosphorylation and translocation of the p47(phox) and p67(phox) cytosolic subunits, the activation of membrane-bound PHOX, and the production of ROS. ros 292-295 mitogen-activated protein kinase 1 Homo sapiens 81-84 21453688-0 2011 Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells. ros 65-68 mitogen-activated protein kinase 1 Homo sapiens 79-82 21620957-0 2011 ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation. ros 0-3 mitogen-activated protein kinase 1 Homo sapiens 23-26 21620957-6 2011 The employment of several inhibitors and antioxidants indicates that a ROS-induced stress-sensitive p38 MAPK/ERK-Akt cascade plays a critical role in the regulation of PA on cell cycle and cell proliferation. ros 71-74 mitogen-activated protein kinase 1 Homo sapiens 109-112 21620957-7 2011 Moreover, PA dose and time dependently activates Nrf2 and this activation relies on ROS-induced stimulation of p38 MAPK/ERK-Akt signaling, demonstrating that Nrf2 activation may be associated with the regulation of PA on cell cycle transition and proliferation. ros 84-87 mitogen-activated protein kinase 1 Homo sapiens 120-123 21620957-8 2011 In conclusion, our study elucidates the importance of PA metabolism on cell proliferation, and suggests that PA stimulates hepatocyte proliferation through activating the ROS-p38 MAPK/ERK-Akt cascade which is intersected with the activation of Nrf2 and that the effect of ROS on signal transduction is in a dose- and time-dependent manner. ros 171-174 mitogen-activated protein kinase 1 Homo sapiens 184-187 20432471-0 2010 Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway. ros 116-119 mitogen-activated protein kinase 1 Homo sapiens 144-147 20432471-3 2010 Pretreatment with BAPTA-AM (Ca(2+) chelator) and N-acetylcysteine (ROS scavenger) abolished caffeine-induced ERK inactivation and p38 MPAK activation. ros 67-70 mitogen-activated protein kinase 1 Homo sapiens 109-112 21998736-6 2011 Inhibition of ROS generation by NAC effectively attenuated the activation of ERK and JNK, induction of ER stress, and subsequent apoptosis. ros 14-17 mitogen-activated protein kinase 1 Homo sapiens 77-80 21998736-7 2011 Importantly, inhibition of ERK abolished ROS generation and ER stress, whereas inhibition of JNK did not, indicating that positive feedback regulation between ERK activation and ROS generation triggers ER stress in response to combined treatment. ros 41-44 mitogen-activated protein kinase 1 Homo sapiens 27-30 21998736-7 2011 Importantly, inhibition of ERK abolished ROS generation and ER stress, whereas inhibition of JNK did not, indicating that positive feedback regulation between ERK activation and ROS generation triggers ER stress in response to combined treatment. ros 41-44 mitogen-activated protein kinase 1 Homo sapiens 159-162 21998736-7 2011 Importantly, inhibition of ERK abolished ROS generation and ER stress, whereas inhibition of JNK did not, indicating that positive feedback regulation between ERK activation and ROS generation triggers ER stress in response to combined treatment. ros 178-181 mitogen-activated protein kinase 1 Homo sapiens 27-30 19939451-4 2010 Especially, Rac-associated ROS-dependent MAP kinases, including ERK1/2 and p38, are involved in MHC class II-associated negative signal transduction in the phorbol 12, 13-dibutyrate (PDBU)-treated, but not LPS-treated, resting B cell line, 38B9. ros 27-30 mitogen-activated protein kinase 1 Homo sapiens 75-78 20368806-0 2010 Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation. ros 83-86 mitogen-activated protein kinase 1 Homo sapiens 97-100 20368806-11 2010 CONCLUSIONS/SIGNIFICANCE: Considering that loss of tumor suppressor beclin 1 is associated with neoplasia, the ability of this small molecule compound to engage both autophagic and apoptotic machineries via ROS production and subsequent activation of ERK and JNK could have potential translational implications. ros 207-210 mitogen-activated protein kinase 1 Homo sapiens 251-254 20402656-10 2010 ERK activation was inhibited by PD98059, Wortmanin and the ROS scavenger NAC (N-acetyl cysteine). ros 59-62 mitogen-activated protein kinase 1 Homo sapiens 0-3 20430109-0 2010 Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells. ros 67-70 mitogen-activated protein kinase 1 Homo sapiens 85-88 20430109-0 2010 Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells. ros 67-70 mitogen-activated protein kinase 1 Homo sapiens 93-97 19700217-5 2010 The release of calcium triggered the production of ROS, which further enhances calcium overloading and subsequently activates p38, JNK and ERK1/2. ros 51-54 mitogen-activated protein kinase 1 Homo sapiens 126-129 18723357-5 2008 Furthermore, preliminary biochemical investigation revealed that CLT was a potent agent to suppress both LPS-induced intracellular ROS production and iNOS expression, and CLT also inhibited the phosphorylation of ERK which is an important protein kinase involved in the activation of TNF-alpha synthesis in LPS-activated macrophages. ros 131-134 mitogen-activated protein kinase 1 Homo sapiens 213-216 19249354-5 2009 MEK/ERK involvement downstream of ROS generation was critical for PAI-1, but not CTGF, expression following cytoskeletal perturbation suggesting bifurcation of signaling pathways downstream of EGFR activation. ros 34-37 mitogen-activated protein kinase 1 Homo sapiens 4-7 20150959-9 2009 Collectively, these results indicate that Fe(2+)-mediated Erk pathway activation is an important signal transduction pathway in ROS-induced IL-8 secretion in epithelial cells. ros 128-131 mitogen-activated protein kinase 1 Homo sapiens 58-61 20360613-7 2010 Studies have shown that p38MAP kinase, nuclear factor kappaB (NF-kappaB), PKC/ERK and JNK/c-Jun all take part in the ROS-activated production of ET-1. ros 117-120 mitogen-activated protein kinase 1 Homo sapiens 78-81 19720122-0 2009 Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway. ros 89-92 mitogen-activated protein kinase 1 Homo sapiens 117-120 19720122-9 2009 Taken together, our data indicate that Fas/FasL upregulation in AA-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2, and suggest that autocrine Fas-mediated apoptotoic mechanism is involved in AA-induced cell death. ros 108-111 mitogen-activated protein kinase 1 Homo sapiens 136-139 19009558-0 2009 Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation. ros 112-115 mitogen-activated protein kinase 1 Homo sapiens 139-143 19009558-4 2009 N-Acetylcysteine (ROS scavenger) and BAPTA-AM (Ca(2+) chelator) abrogated p38 MAPK activation and upregulation of Fas and FasL expression, but restored phosphorylation of ERK. ros 18-21 mitogen-activated protein kinase 1 Homo sapiens 78-82 19009558-8 2009 Taken together, our results indicate that PLA(2)-induced cell death is, in part, elicited by upregulation of Fas and FasL, which is regulated by Ca(2+)- and ROS-evoked p38 MAPK activation, and suggest that non-catalytic PLA(2) plays a role for the signaling pathway. ros 157-160 mitogen-activated protein kinase 1 Homo sapiens 172-176 9546582-5 1998 Mainly ERK2 was rapidly activated (within 10 min) by bFGF, IGF-I and PDGF-BB in normal HOB, HBMS and human osteosarcoma cells, whereas both ERK1 and ERK2 were activated by growth factors in rat osteoblast-like cell lines, ROS 17/2.8 and UMR-106. ros 222-225 mitogen-activated protein kinase 1 Homo sapiens 7-11 16904205-0 2006 Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate. ros 59-62 mitogen-activated protein kinase 1 Homo sapiens 63-66 16632126-6 2006 Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126. ros 122-125 mitogen-activated protein kinase 1 Homo sapiens 126-129 16632126-6 2006 Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126. ros 122-125 mitogen-activated protein kinase 1 Homo sapiens 212-216 16632126-6 2006 Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126. ros 122-125 mitogen-activated protein kinase 1 Homo sapiens 217-220 15226155-0 2004 EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death. ros 97-100 mitogen-activated protein kinase 1 Homo sapiens 31-34 12151316-8 2002 Herein we present a novel action of proteasome inhibitors, possibly through ROS production, of targeting the upstream signaling molecules, ERK and JNK, which leads to AP-1 activation and IL-8 gene expression. ros 76-79 mitogen-activated protein kinase 1 Homo sapiens 139-142 18064629-10 2008 We conclude that atRA protects against UV-induced down-regulation AQP3 and decrease in water permeability, reduction in cell migration and delayed in vitro wound healing via trans-activation of EGFR and inhibition on ROS-mediated MEK/ERK pathway. ros 217-220 mitogen-activated protein kinase 1 Homo sapiens 234-237 15880691-7 2005 Moreover, blockage of the MEK/ERK pathway caused a breakdown of the mitochondrial membrane potential accompanied by an elevation in the ROS production. ros 136-139 mitogen-activated protein kinase 1 Homo sapiens 30-33 9546582-5 1998 Mainly ERK2 was rapidly activated (within 10 min) by bFGF, IGF-I and PDGF-BB in normal HOB, HBMS and human osteosarcoma cells, whereas both ERK1 and ERK2 were activated by growth factors in rat osteoblast-like cell lines, ROS 17/2.8 and UMR-106. ros 222-225 mitogen-activated protein kinase 1 Homo sapiens 149-153