PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34739306-5	2022	Simultaneously, they can reset the levels of pro-apoptotic proteins that belong to the Bcl-2 and caspase family and decrease the intracellular levels of ROS and pro-inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6.	ros	153-156	interleukin 1 alpha	Homo sapiens	208-216	
16095823-4	2005	LPS+IL-(1beta) induced oxidative injury as assessed by ROS production (29%), GSH depletion (11%) and loss of mitochondrial activity (22%).	ros	55-58	interleukin 1 alpha	Homo sapiens	4-13	
34930286-8	2021	Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappaB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	ros	37-40	interleukin 1 alpha	Homo sapiens	141-149	
17981627-4	2008	Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury.	ros	185-188	interleukin 1 alpha	Homo sapiens	71-80	
11752025-14	2002	ROS also partially mediate the effects of PMA and IL-1 on podocyte GM-CSF production.	ros	0-3	interleukin 1 alpha	Homo sapiens	50-54	
34875574-8	2022	LPS, PGN, and MDP induced FM IL-1beta and IL-18 secretion in a non-pyroptotic manner through activation of the NLRP3 inflammasome with contributions from ATP release through Pannexin-1, and ROS signaling.	ros	190-193	interleukin 1 alpha	Homo sapiens	29-37	
34822966-7	2022	The Cat/Re@PLGA@UCM NPs also exhibited outstanding ROS scavenging properties, downregulating ICAM-1, TNF-alpha and IL-1beta, while preventing angiogenesis to attenuate the progression of AS.	ros	51-54	interleukin 1 alpha	Homo sapiens	115-123	
34056995-7	2021	Therefore, this work demonstrates for the first time that L-carnosine may be used as adjuvant therapy for the preservation of visual integrity in patients with DED.HighlightsIL-1alpha induced dry eye disease through its oxidative stress, proinflammatory, apoptotic and profibrotic effects on the lacrimal glands of rabbit.L-carnosine has antioxidant, anti-inflammatory, antiapoptotic and antifibrotic effects.L-carnosine mitigated IL-1alpha induced dry eye disease via elevating the levels of FasL, IFN-gamma, TNF-alpha, TGFbeta1 and MDA as well as reducing the levels of antioxidants (GPx, SOD, and catalase) and ROS in the lacrimal glands of rabbit.L-carnosine could be used as a novel adjuvant therapy for the treatment of dry eye disease.	ros	614-617	interleukin 1 alpha	Homo sapiens	174-183	
35217429-6	2022	Sperm exposed to different concentrations of IFNgamma, IL-17A and IL-1beta, or a combination of them, for either 1 or 3 h showed significantly increased levels of mitochondrial ROS production and reduced motility and viability with respect to sperm incubated with vehicle.	ros	177-180	interleukin 1 alpha	Homo sapiens	66-74	
35217429-9	2022	In conclusion, our results indicate that IFNgamma, IL-17A and IL-1beta per se impair sperm motility and decreases viability by triggering increased mitochondrial ROS production and inducing sperm apoptosis.	ros	162-165	interleukin 1 alpha	Homo sapiens	62-70	
34078931-6	2021	As the results, we found that treatment with recombinant human His6-GABARAP protein promoted cell proliferation, inhibited apoptosis, and reduced ROS generation by increasing autophagic activity, particularly when co-cultured with IL-1beta.	ros	146-149	interleukin 1 alpha	Homo sapiens	231-239	
35346830-9	2022	This study showed that miR-1656 could increase the release of ROS by targeting GPX4, activated the NLRP3 inflammasome, and release the inflammatory factors IL-1beta and IL-18 to trigger pyroptosis in the kidney tissue of Se-deficient broilers.	ros	62-65	interleukin 1 alpha	Homo sapiens	156-164	
32803561-7	2020	Moreover, the exogenous antioxidant application of the LA from the LCNs can prevent ROS damage, which was demonstrated by this study with the less myeloperoxidase (MPO) activity and decrease in cytokine levels (TNF-alpha and IL-1beta) generated by the oxidative stress modulation.	ros	84-87	interleukin 1 alpha	Homo sapiens	225-233	
33729569-10	2021	RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner.	ros	154-157	interleukin 1 alpha	Homo sapiens	35-43	
32898504-7	2020	We found that HL-1 cardiomyocytes moderately expressed the GLP-1 receptor, and co-treatment with Liraglutide ameliorated IL-1beta-induced cellular ROS production and NADPH oxidase (NOX)-4 expression.	ros	147-150	interleukin 1 alpha	Homo sapiens	121-129	
32103437-6	2020	Moreover, measurement by confocal microscopy and flow cytometry assay indicates that Ti ions can promote the production of ROS, while NLRP3 expression and IL-1beta secretion are reduced after treatment of Jurkat cells with NAC (ROS scavenger).	ros	228-231	interleukin 1 alpha	Homo sapiens	155-163	
32191437-5	2020	In our research, we found that laquinimod could ameliorate IL-1beta-induced generation of ROS and improve mitochondrial function by increasing mitochondrial membrane potential (DeltaPsim).	ros	90-93	interleukin 1 alpha	Homo sapiens	59-67	
32432601-0	2020	Pelargonidin ameliorates CCl4-induced liver fibrosis by suppressing the ROS-NLRP3-IL-1beta axis via activating the Nrf2 pathway.	ros	72-75	interleukin 1 alpha	Homo sapiens	82-90	
31178664-7	2019	Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation.	ros	16-19	interleukin 1 alpha	Homo sapiens	96-104	
31835256-10	2019	Furthermore, prior treatment with ROS scavenger, NAC significantly attenuated the nicotine-induced caspase-1 activity, IL-1beta production, podocin and nephrin reduction in podocytes.	ros	34-37	interleukin 1 alpha	Homo sapiens	119-127	
31412804-0	2019	Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux.	ros	128-131	interleukin 1 alpha	Homo sapiens	26-34	
31412804-13	2019	CONCLUSIONS: UA could regulate NLRP3/IL-1beta signaling pathway through ROS activation and K+ efflux and further induce vascular endothelial cells injury in early stages of CKD.	ros	72-75	interleukin 1 alpha	Homo sapiens	37-45	
28011320-7	2017	In autophagy-deficient macrophages, mitochondrial ROS mediated inflammation- and fibrosis-promoting effects by increasing IL1alpha/beta production via enhancing NF-kappaB-associated pathways.	ros	50-53	interleukin 1 alpha	Homo sapiens	122-130	
29720213-11	2018	ROS was required for PM2.5-induced IL-1beta production and NLRP3 inflammasome activation in oAbeta-stimulated microglia.	ros	0-3	interleukin 1 alpha	Homo sapiens	35-43	
28011320-9	2017	In conclusion, autophagy-deficient Kupffer cells promote liver fibrosis, inflammation and, finally, hepatocarcinogenesis during the preneoplastic stage by enhancing mitochondrial ROS- NF-kappaB-IL1alpha/beta pathways.	ros	179-182	interleukin 1 alpha	Homo sapiens	194-202