PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32660255-5	2021	The inhibition of Cdk5 also ameliorated mitochondrial dysfunction by decreasing ROS levels and cytochrome c release, while increasing ATP production.	ros	80-83	cyclin dependent kinase 5	Homo sapiens	18-22	
29348461-8	2018	Apoptosis is completely prevented by mPTP inhibition, almost fully inhibited by blocking ROS and unaffected by inhibition of mitochondrial fission, suggesting that apoptosis in breast cancer cells due to Cdk5 loss occurs via a novel mPTP-dependent mechanism that acts primarily through ROS increase.	ros	89-92	cyclin dependent kinase 5	Homo sapiens	204-208	
31163256-11	2019	Inhibition of CDK5 with myricetin or roscovitine, a CDK5 inhibitor attenuates thapsigargin induced p66Shc serine 36 phosphorylation and also reduced mitochondrial dysfunction by decreasing mitochondrial ROS and caspase-3 activation.	ros	203-206	cyclin dependent kinase 5	Homo sapiens	14-18	
29348461-0	2018	Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore.	ros	45-48	cyclin dependent kinase 5	Homo sapiens	8-12	
29348461-8	2018	Apoptosis is completely prevented by mPTP inhibition, almost fully inhibited by blocking ROS and unaffected by inhibition of mitochondrial fission, suggesting that apoptosis in breast cancer cells due to Cdk5 loss occurs via a novel mPTP-dependent mechanism that acts primarily through ROS increase.	ros	286-289	cyclin dependent kinase 5	Homo sapiens	204-208	
10884379-16	2000	Together, our results strongly suggest that after activation of PDE by light/GTP, Pgamma is phosphorylated by Cdk5 and the phosphorylated Pgamma inhibits GTP/Talpha-activated PDE, even in the presence of GTP/Talpha in ROS.	ros	218-221	cyclin dependent kinase 5	Homo sapiens	110-114	
10884379-8	2000	Here, using frog rod photoreceptor outer segments (ROS) isolated by a new method, we show that Cdk5 is involved in light-dependent Pgamma phosphorylation in vivo.	ros	51-54	cyclin dependent kinase 5	Homo sapiens	95-99	
10884379-12	2000	These observations, together with immunological data showing the presence of Cdk5 in ROS, suggest that Cdk5 is involved in light-dependent Pgamma phosphorylation in ROS and that the phosphorylation is significant and reversible.	ros	85-88	cyclin dependent kinase 5	Homo sapiens	77-81	
10884379-12	2000	These observations, together with immunological data showing the presence of Cdk5 in ROS, suggest that Cdk5 is involved in light-dependent Pgamma phosphorylation in ROS and that the phosphorylation is significant and reversible.	ros	85-88	cyclin dependent kinase 5	Homo sapiens	103-107	
10884379-12	2000	These observations, together with immunological data showing the presence of Cdk5 in ROS, suggest that Cdk5 is involved in light-dependent Pgamma phosphorylation in ROS and that the phosphorylation is significant and reversible.	ros	165-168	cyclin dependent kinase 5	Homo sapiens	103-107