PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30447254-3 2019 This is mediated by a ROS-independent activation of the MAP kinase JNK. ros 22-25 mitogen-activated protein kinase 8 Homo sapiens 67-70 31172987-6 2019 WZ35, a novel curcumin derivative, exhibits potential anti-tumor activity in gastric cancer cells by regulating ROS dependent JNK activation and ER stress. ros 112-115 mitogen-activated protein kinase 8 Homo sapiens 126-129 31401057-5 2019 In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK). ros 55-58 mitogen-activated protein kinase 8 Homo sapiens 266-269 31776986-4 2019 This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways. ros 27-30 mitogen-activated protein kinase 8 Homo sapiens 88-91 31401057-5 2019 In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK). ros 55-58 mitogen-activated protein kinase 8 Homo sapiens 266-269 31401057-0 2019 ROS-mediated JNK pathway critically contributes to PFOS-triggered apoptosis in SH-SY5Y cells. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 13-16 31401057-5 2019 In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK). ros 145-148 mitogen-activated protein kinase 8 Homo sapiens 111-114 31401057-5 2019 In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK). ros 55-58 mitogen-activated protein kinase 8 Homo sapiens 111-114 31401057-5 2019 In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK). ros 145-148 mitogen-activated protein kinase 8 Homo sapiens 266-269 31401057-5 2019 In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK). ros 145-148 mitogen-activated protein kinase 8 Homo sapiens 266-269 31401057-6 2019 In keeping with this notion, the expression of JNK downstream pro-apoptotic target Bim was increased following PFOS exposure in JNK- and ROS-dependent manners. ros 137-140 mitogen-activated protein kinase 8 Homo sapiens 47-50 29766185-0 2018 The curcumin derivative WZ35 activates ROS-dependent JNK to suppress hepatocellular carcinoma metastasis. ros 39-42 mitogen-activated protein kinase 8 Homo sapiens 53-56 30169763-7 2018 Simultaneously, the signaling pathway of ROS/JNK/FOXO3a of DON-induced cytotoxicity was newly proposed. ros 41-44 mitogen-activated protein kinase 8 Homo sapiens 45-48 30169763-8 2018 In total, FOXO3a via ROS/JNK/FOXO3a plays a critical role to function as negative regulator associating with DON-induced cytotoxicity, with the potential extending to other substances. ros 21-24 mitogen-activated protein kinase 8 Homo sapiens 25-28 30584464-0 2018 High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway. ros 21-24 mitogen-activated protein kinase 8 Homo sapiens 103-106 30584464-7 2018 Collectively, high levels of ROS induced by high glucose conditions stimulated the proliferation of pancreatic cancer cells, and it may be achieved by inactivating the JNK pathway. ros 29-32 mitogen-activated protein kinase 8 Homo sapiens 168-171 29754474-11 2018 Therefore, OMT-induced injury in L02 cells was related to ROS mediated p-JNK and ER stress induction. ros 58-61 mitogen-activated protein kinase 8 Homo sapiens 73-76 29766185-10 2018 In addition, our data show that WZ35 promotes ROS-dependent JNK activation that is essential for WZ35-caused cell metastasis suppression. ros 46-49 mitogen-activated protein kinase 8 Homo sapiens 60-63 29655083-0 2018 Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-kappaB pathway inhibition. ros 103-106 mitogen-activated protein kinase 8 Homo sapiens 116-119 29655083-6 2018 Further, 5B was found to exert anti-tumor effects through ROS-mediated activation of JNK pathway and inhibition of NF-kappaB pathway. ros 58-61 mitogen-activated protein kinase 8 Homo sapiens 85-88 29348836-7 2017 Consequently, HSF-1 hyperphosphorylation mediated by JNK operation causes transcriptional inactivation of HSF-1, and supported ROS-mediated autophagy induction. ros 127-130 mitogen-activated protein kinase 8 Homo sapiens 53-56 28712866-0 2017 Cell-free methemoglobin drives platelets to apoptosis via mitochondrial ROS-mediated activation of JNK and p38 MAP kinase. ros 72-75 mitogen-activated protein kinase 8 Homo sapiens 99-102 29649125-6 2018 The formation of ROS is closely related to the activation of the stress-activated kinases, JNK and p38, while SP600125 (SP, JNK inhibitor) and SB203580 (SB, p38 inhibitor) pretreatment inhibited the generation of ROS. ros 17-20 mitogen-activated protein kinase 8 Homo sapiens 91-94 29552311-9 2018 We therefore demonstrated that miR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1/ROS/JNK pathway. ros 111-114 mitogen-activated protein kinase 8 Homo sapiens 115-118 28103509-7 2017 Collectively, our results suggest that DTMF stimulates ROS-mediated oxidative stress, which in turn induces PERK-CHOP and JNK pathway of apoptosis to promote HCT-116 cell death. ros 55-58 mitogen-activated protein kinase 8 Homo sapiens 122-125 28518151-0 2017 Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-kappaB and Nrf2. ros 115-118 mitogen-activated protein kinase 8 Homo sapiens 119-122 28518151-8 2017 Mechanistically, DS/Cu-induced cytotoxicity was closely associated with activation of the stress-related ROS-JNK pathway as well as simultaneous inactivation of the pro-survival Nrf2 and nuclear factor-kappaB pathways. ros 105-108 mitogen-activated protein kinase 8 Homo sapiens 109-112 29088756-7 2017 The ROS, produced by DHS activated the p38 and JNK MAPKs to augment the BAX activity and BID-cleavage, and induce LMP and MMP in the cells. ros 4-7 mitogen-activated protein kinase 8 Homo sapiens 47-50 27181592-0 2017 JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production. ros 113-116 mitogen-activated protein kinase 8 Homo sapiens 0-3 27181592-9 2017 Additionally, inhibition of JNK with SP600125 alleviated intracellular accumulation of ROS and attenuated mitochondrial generation of superoxide. ros 87-90 mitogen-activated protein kinase 8 Homo sapiens 28-31 27181592-10 2017 Thus, we demonstrated that JNK activation contributes to glioma cell parthanatos caused by oxidative stress via increase of intracellular ROS generation. ros 138-141 mitogen-activated protein kinase 8 Homo sapiens 27-30 28488794-0 2017 Apoptotic Activity of Lactobacillus plantarum DGK-17-Fermented Soybean Seed Extract in Human Colon Cancer Cells via ROS-JNK Signaling Pathway. ros 116-119 mitogen-activated protein kinase 8 Homo sapiens 120-123 28662515-9 2017 CONCLUSIONS: Our results revealed that shikonin could inhibit cells viability and induce apoptosis of CCA cells, effects enhanced by TRAIL treatment via ROS mediated JNK signalling pathways, involving up-regulation of DR5 expression. ros 153-156 mitogen-activated protein kinase 8 Homo sapiens 166-169 28662515-7 2017 Furhermore, TRAIL enhanced anti-proliferation of shikonin and shikonin induced apoptosis through induction of ROS mediated JNK activation, while AKT activation had an effect on shikonin anti-proliferation activity, but not in the TRAIL enhanced counterparts. ros 110-113 mitogen-activated protein kinase 8 Homo sapiens 123-126 27899257-11 2017 In addition, the ROS scavenger also inhibited G2/M phase arrest and phosphorylated JNK. ros 17-20 mitogen-activated protein kinase 8 Homo sapiens 83-86 27392019-0 2016 Correction: Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation. ros 95-98 mitogen-activated protein kinase 8 Homo sapiens 117-120 26472167-8 2016 In conclusion, our results indicate that ROS-JNK/ERK-apoptosis and G0/G1 arrest pathways are involved in PM2.5 -induced embryotoxicity, which not only provides insights into the molecular mechanism of PM2.5 -induced embryotoxicity, but also may help to identify specific interventions to improve adverse pregnancy outcomes of PM2.5 . ros 41-44 mitogen-activated protein kinase 8 Homo sapiens 45-48 27108344-5 2016 Meanwhile, the ROS scavenger N-acetyl-L-cysteine (NAC) and the Jnk inhibitor SP600125 were found to inhibit the MPPa-PDT-induced autophagy, and NAC could also inhibit Jnk phosphorylation. ros 15-18 mitogen-activated protein kinase 8 Homo sapiens 167-170 26502273-6 2016 Graphene activates apoptosis in macrophages through the TGFbr/Smad/Bcl-2 pathway and also through JNK kinases that are stimulated by an increase of ROS in the cell or through a signal received by Smad proteins. ros 148-151 mitogen-activated protein kinase 8 Homo sapiens 98-101 27108344-8 2016 Meanwhile the ROS-Jnk signaling pathway was involved in MPPa-PDT-induced autophagy, which further promoted the apoptosis in MG-63 cells. ros 14-17 mitogen-activated protein kinase 8 Homo sapiens 18-21 26468015-0 2016 ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic effect of ajoene on cells of lung adenocarcinoma. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 27-30 26086416-7 2016 Blockage of ROS production totally reversed WZ26-induced JNK activation, Bcl-2/Bax decrease, ER stress activation, and final cell apoptosis in SGC-7901 cells. ros 12-15 mitogen-activated protein kinase 8 Homo sapiens 57-60 26468015-11 2016 Our results suggest that ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic action of ajoene on cells of lung adenocarcinoma. ros 25-28 mitogen-activated protein kinase 8 Homo sapiens 52-55 26511233-8 2016 This leads to the activation of calcineurin B, independent of NFAT involvement, which in coordination with ROS induces the activation of JNK of the MAPK signalling. ros 107-110 mitogen-activated protein kinase 8 Homo sapiens 137-140 26716417-7 2016 Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins. ros 130-133 mitogen-activated protein kinase 8 Homo sapiens 73-76 26716417-7 2016 Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins. ros 130-133 mitogen-activated protein kinase 8 Homo sapiens 157-160 26707143-0 2016 Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells. ros 72-75 mitogen-activated protein kinase 8 Homo sapiens 81-84 27563337-3 2016 IRE1-JNK and eIF2alpha-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors. ros 118-121 mitogen-activated protein kinase 8 Homo sapiens 5-8 26235743-0 2015 New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway. ros 97-100 mitogen-activated protein kinase 8 Homo sapiens 101-104 26642060-8 2015 Molecular and cell biological studies demonstrated that HG increased ROS production, whereas treatment with bFGF or JNK/ERK inhibitors blocked HG-induced ROS accumulation. ros 154-157 mitogen-activated protein kinase 8 Homo sapiens 116-119 26086160-8 2015 Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway. ros 187-190 mitogen-activated protein kinase 8 Homo sapiens 103-106 26235743-11 2015 CONCLUSION: The new benzimidazole acridine derivative, 8m exerts anticancer activity against human colon cancer cells in vitro by inducing both intrinsic and extrinsic apoptosis pathways via the ROS-JNK1 pathway. ros 195-198 mitogen-activated protein kinase 8 Homo sapiens 199-203 25909160-5 2015 Also, IL-32alpha increased ROS production to induce prolonged JNK activation. ros 27-30 mitogen-activated protein kinase 8 Homo sapiens 62-65 26001727-0 2015 c-Jun N-terminal kinase attenuates TNFalpha signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells. ros 91-94 mitogen-activated protein kinase 8 Homo sapiens 0-23 26001727-11 2015 These data suggest that JNK suppresses the inflammatory response to TNFalpha by reducing Nox1-dependent endosomal ROS production. ros 114-117 mitogen-activated protein kinase 8 Homo sapiens 24-27 26203587-14 2015 In addition, the quenching of ROS using NAC prevented the induction of JNK phosphorylation and CHOP induction. ros 30-33 mitogen-activated protein kinase 8 Homo sapiens 71-74 26203587-16 2015 Taken together, these data suggest that TIIA enhances TRAIL-induced apoptosis by upregulating DR5 receptors through the ROS-JNK-CHOP signaling axis in human ovarian carcinoma cells. ros 120-123 mitogen-activated protein kinase 8 Homo sapiens 124-127 25615876-3 2015 The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs. ros 208-211 mitogen-activated protein kinase 8 Homo sapiens 142-145 26002468-0 2015 Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK. ros 51-54 mitogen-activated protein kinase 8 Homo sapiens 65-68 26002468-8 2015 Thus, we demonstrate that PA stimulates autophagy and apoptosis via ROS-dependent JNK and p38 MAPK pathways. ros 68-71 mitogen-activated protein kinase 8 Homo sapiens 82-85 25529445-0 2015 Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROS-Ca(2+)-JNK mitochondrial pathways. ros 69-72 mitogen-activated protein kinase 8 Homo sapiens 80-83 25832424-8 2015 Pretreatment of the cells with the ROS scavenger N-acetyl-L-cysteine, ERK inhibitor PD98059 or NF-kappaB inhibitor PDTC blocked CRP-stimulated RAGE expression, but pretreatment with the NADPH oxidase inhibitor DPI, JNK inhibitor SP600125 or p38 MAPK inhibitor SB203580 did not significantly alter CRP-stimulated RAGE expression. ros 35-38 mitogen-activated protein kinase 8 Homo sapiens 215-218 25611379-11 2015 The ROS scavenger also prevented G2/M phase arrest and phosphorylation of JNK. ros 4-7 mitogen-activated protein kinase 8 Homo sapiens 74-77 25529445-7 2015 It seems that ROS may act as an upstream regulator of EPA-induced [Ca(2+)]c generation, moreover, generation of ROS, overload of mitochondrial [Ca(2+)]c, and JNK activated cause the opening of MPTP. ros 14-17 mitogen-activated protein kinase 8 Homo sapiens 158-161 25529445-8 2015 Western blotting results showed that EPA elevated the phosphorylation status of JNK, processes associated with the ROS generation. ros 115-118 mitogen-activated protein kinase 8 Homo sapiens 80-83 25529445-10 2015 These results suggest that EPA induces apoptosis through ROS-Ca(2+)-JNK mitochondrial pathways. ros 57-60 mitogen-activated protein kinase 8 Homo sapiens 68-71 25044446-8 2014 Further, the effects of oxHDL for the enhanced formation of MMP-9 were found to be mediated by NADPH oxidase/ROS-JNK/ERK pathway, as one mechanism. ros 109-112 mitogen-activated protein kinase 8 Homo sapiens 113-116 26180584-8 2015 Finally, we demonstrated that PCA induced the activation of JNK, which, in turn, determined the increase of nuclear Nrf2, leading to inhibition of the early ROS overproduction. ros 157-160 mitogen-activated protein kinase 8 Homo sapiens 60-63 25791820-0 2015 Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways. ros 101-104 mitogen-activated protein kinase 8 Homo sapiens 105-108 25791820-12 2015 Antimitotic compound C9 in combination with a glycolytic inhibitor dichloroacetate eradicates breast cancer cells through ROS-JNK-Bcl-2-mediated signalling pathways in vitro and it is argued that autophagy acts as protective mechanism in the treated cells before apoptosis occurs. ros 122-125 mitogen-activated protein kinase 8 Homo sapiens 126-129 26089952-6 2015 High level of ROS was provoked by P2, which was in turn responsible for induction of apoptosis through activation of intrinsic mitochondrial pathway and JNK1/2, p38 MAPK pathways, as well as inhibition of ERK1/2 pathway, as evidenced by the abrogation of P2"s effect on HeLa cells preincubated with the ROS scavenger NAC. ros 14-17 mitogen-activated protein kinase 8 Homo sapiens 153-159 25305377-0 2014 Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells. ros 53-56 mitogen-activated protein kinase 8 Homo sapiens 99-102 25064608-3 2014 However, the relationship between NADPH oxidase-ROS and JNK MAPK signal still remains unclear. ros 48-51 mitogen-activated protein kinase 8 Homo sapiens 56-59 25064608-4 2014 Here, we discovered a novel self-driven signal circuit between NADPH oxidase-ROS and JNK MAPK, which was induced by a cytotoxic steroidal saponin (ASC) in hepatoma carcinoma cells. ros 77-80 mitogen-activated protein kinase 8 Homo sapiens 85-88 25064608-5 2014 NADPH oxidase-dependent ROS production was markedly activated by ASC and directly led to JNK MAPK activation. ros 24-27 mitogen-activated protein kinase 8 Homo sapiens 89-92 25321472-9 2014 In conclusion, our results suggest that Med sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the upregulation of DR5 through activation of the ROS-JNK-CHOP pathway. ros 163-166 mitogen-activated protein kinase 8 Homo sapiens 167-170 25064608-6 2014 Moreover, antioxidant, NADPH oxidase inhibitor and specific knock-out for p47 subunit of NADPH oxidase could effectively block NADPH oxidase-ROS-dependent JNK activation, suggesting that NADPH oxidase is an upstream regulator of JNK MAPK. ros 141-144 mitogen-activated protein kinase 8 Homo sapiens 155-158 25064608-6 2014 Moreover, antioxidant, NADPH oxidase inhibitor and specific knock-out for p47 subunit of NADPH oxidase could effectively block NADPH oxidase-ROS-dependent JNK activation, suggesting that NADPH oxidase is an upstream regulator of JNK MAPK. ros 141-144 mitogen-activated protein kinase 8 Homo sapiens 229-232 25064608-7 2014 Conversely, a specific JNK inhibitor could inhibit ASC-induced NADPH oxidase activation and down-regulate ROS levels as well, indicating that JNK might also regulate NADPH oxidase activity to some extent. ros 106-109 mitogen-activated protein kinase 8 Homo sapiens 23-26 25064608-7 2014 Conversely, a specific JNK inhibitor could inhibit ASC-induced NADPH oxidase activation and down-regulate ROS levels as well, indicating that JNK might also regulate NADPH oxidase activity to some extent. ros 106-109 mitogen-activated protein kinase 8 Homo sapiens 142-145 25064608-10 2014 Taken together, we provide a proof for inducing hepatoma carcinoma cell apoptosis by activating the JNK-NADPH oxidase-ROS-dependent self-driven signal circuit pathway. ros 118-121 mitogen-activated protein kinase 8 Homo sapiens 100-103 25341038-9 2014 Using a small-molecule inhibitor of 20S proteasome and ROS-inducer--withaferin A (WA), we found that WA-induced ROS activates JNK kinase and stabilizes phase II anti-oxidant response effector NF-E2-related transcription factor (NRF2). ros 55-58 mitogen-activated protein kinase 8 Homo sapiens 126-129 25341038-9 2014 Using a small-molecule inhibitor of 20S proteasome and ROS-inducer--withaferin A (WA), we found that WA-induced ROS activates JNK kinase and stabilizes phase II anti-oxidant response effector NF-E2-related transcription factor (NRF2). ros 112-115 mitogen-activated protein kinase 8 Homo sapiens 126-129 25321472-0 2014 Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway. ros 145-148 mitogen-activated protein kinase 8 Homo sapiens 149-152 25305377-7 2014 ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 101-124 25305377-7 2014 ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 126-129 23353183-2 2013 At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylation in DU-145 prostate cancer cells. ros 43-46 mitogen-activated protein kinase 8 Homo sapiens 69-72 24812029-0 2014 Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells. ros 13-16 mitogen-activated protein kinase 8 Homo sapiens 29-32 24122234-4 2014 Studies on amsacrine-treated U937 cells revealed that amsacrine-elicited ROS generation induced JNK and p38 MAPK activation but reduced the phospho-ERK level. ros 73-76 mitogen-activated protein kinase 8 Homo sapiens 96-99 24366007-11 2014 Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis. ros 127-130 mitogen-activated protein kinase 8 Homo sapiens 101-104 24366007-11 2014 Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis. ros 230-233 mitogen-activated protein kinase 8 Homo sapiens 101-104 24465942-5 2014 Simultaneously, ROS/RNS activate c-Jun NH2-terminal kinase (JNK) and p38 kinase. ros 16-19 mitogen-activated protein kinase 8 Homo sapiens 33-58 24465942-5 2014 Simultaneously, ROS/RNS activate c-Jun NH2-terminal kinase (JNK) and p38 kinase. ros 16-19 mitogen-activated protein kinase 8 Homo sapiens 60-63 24465942-7 2014 Pretreatment of the cells with antioxidants, JNK and p38 inhibitors, or JNK and p38 siRNA abrogates the depolarization of mitochondrial membrane potential and impairs the air plasma-induced apoptotic cell death, suggesting that the ROS/RNS generated by plasma trigger signaling pathways involving JNK and p38 and promote mitochondrial perturbation, leading to apoptosis. ros 232-235 mitogen-activated protein kinase 8 Homo sapiens 72-75 24465942-7 2014 Pretreatment of the cells with antioxidants, JNK and p38 inhibitors, or JNK and p38 siRNA abrogates the depolarization of mitochondrial membrane potential and impairs the air plasma-induced apoptotic cell death, suggesting that the ROS/RNS generated by plasma trigger signaling pathways involving JNK and p38 and promote mitochondrial perturbation, leading to apoptosis. ros 232-235 mitogen-activated protein kinase 8 Homo sapiens 72-75 23973637-0 2013 Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway. ros 139-142 mitogen-activated protein kinase 8 Homo sapiens 143-146 23973637-6 2013 A comparison among the most clinically used PIs, ritonavir (RTV), LPV, and DRV, revealed that LPV potently and RTV moderately but not DRV induced ER stress via ROS-dependent JNK activation rather than proteasome inhibition. ros 160-163 mitogen-activated protein kinase 8 Homo sapiens 174-177 23667638-13 2013 Collectively, elevated homocysteine induced the apoptosis of BMSCs via ROS-induced the activation of JNK signal, which provides more insight into the molecular mechanisms of hyperhomocysteinemia-related cardiovascular diseases. ros 71-74 mitogen-activated protein kinase 8 Homo sapiens 101-104 25175743-11 2014 Our results show that JNK activation is an early event that precedes the increase in ROS levels leading to myofibroblastic differentiation and tumor fibrosis, suggesting that inhibition of JNK may be used a method to interrupt the development of tumor desmoplasia. ros 85-88 mitogen-activated protein kinase 8 Homo sapiens 22-25 25175743-11 2014 Our results show that JNK activation is an early event that precedes the increase in ROS levels leading to myofibroblastic differentiation and tumor fibrosis, suggesting that inhibition of JNK may be used a method to interrupt the development of tumor desmoplasia. ros 85-88 mitogen-activated protein kinase 8 Homo sapiens 189-192 24915933-0 2014 Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition. ros 55-58 mitogen-activated protein kinase 8 Homo sapiens 59-62 24915933-18 2014 Moreover, ROS-related activation of JNK pathway and inhibition of NF-kappaB and Nrf2 may also contribute to the DS/Cu induced apoptosis. ros 10-13 mitogen-activated protein kinase 8 Homo sapiens 36-39 24386346-6 2013 Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation. ros 26-29 mitogen-activated protein kinase 8 Homo sapiens 79-82 24386346-6 2013 Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation. ros 26-29 mitogen-activated protein kinase 8 Homo sapiens 227-230 23933736-6 2013 Additionally, the decrease in JNK1 phosphorylation observed with Myc knockdown is associated with a reduction in ROS production. ros 113-116 mitogen-activated protein kinase 8 Homo sapiens 30-34 23696052-7 2013 In IGROV-1 cells 5F203-induced ROS formation was accompanied by JNK, ERK and P38MAPK phosphorylation, DNA damage and cell cycle arrest prior to apoptosis. ros 31-34 mitogen-activated protein kinase 8 Homo sapiens 64-67 23353183-3 2013 Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation. ros 239-242 mitogen-activated protein kinase 8 Homo sapiens 31-34 20360613-7 2010 Studies have shown that p38MAP kinase, nuclear factor kappaB (NF-kappaB), PKC/ERK and JNK/c-Jun all take part in the ROS-activated production of ET-1. ros 117-120 mitogen-activated protein kinase 8 Homo sapiens 86-89 22627996-9 2013 In conclusion, xanthorrhizol may induce caspase-independent apoptosis through ROS-mediated p38 MAPK and JNK activation in SCC-15 OSCC cells and prevent chemical-induced oral carcinogenesis. ros 78-81 mitogen-activated protein kinase 8 Homo sapiens 104-107 22881126-7 2012 Then after administration of ERK, JNK and P38 inhibitors, only JNK inhibitor SP600125 effectively augmented oridonin-induced apoptosis and ROS generation. ros 139-142 mitogen-activated protein kinase 8 Homo sapiens 63-66 22881126-10 2012 Inhibition of EGFR augmented oridonin-induced apoptosis and this was caused by enhanced oxidative stress, and JNK played a major protective role by increasing autophagy, leading to antagonising apoptosis and ROS generation. ros 208-211 mitogen-activated protein kinase 8 Homo sapiens 110-113 22472731-8 2012 Further studies demonstrated that ROS generation was involved in JNK activation, and Bcl-2 family anti-apoptotic proteins Mcl-1 and Bcl-xl were downstream targets of JNK to mediate apoptosis. ros 34-37 mitogen-activated protein kinase 8 Homo sapiens 65-68 22472731-8 2012 Further studies demonstrated that ROS generation was involved in JNK activation, and Bcl-2 family anti-apoptotic proteins Mcl-1 and Bcl-xl were downstream targets of JNK to mediate apoptosis. ros 34-37 mitogen-activated protein kinase 8 Homo sapiens 166-169 22288910-12 2012 Taken together, these results demonstrate that 2-ABP induces the carcinogenic factor COX-2 and that this induction is mediated through NADPH oxidase-derived ROS-dependent JNK/ERK-AP-1 pathways. ros 157-160 mitogen-activated protein kinase 8 Homo sapiens 171-174 20940027-5 2011 Furthermore, western blot analysis of p53, JNK, and caspase-3 showed that ROS generation was accompanied by JNK activation. ros 74-77 mitogen-activated protein kinase 8 Homo sapiens 43-46 20940027-5 2011 Furthermore, western blot analysis of p53, JNK, and caspase-3 showed that ROS generation was accompanied by JNK activation. ros 74-77 mitogen-activated protein kinase 8 Homo sapiens 108-111 21998736-6 2011 Inhibition of ROS generation by NAC effectively attenuated the activation of ERK and JNK, induction of ER stress, and subsequent apoptosis. ros 14-17 mitogen-activated protein kinase 8 Homo sapiens 85-88 21998736-12 2011 When NQO1(+) cells are treated with combination of IR and beta-lap, positive feedback regulation between ERK and ROS leads to ER stress causing JNK activation and mitochondrial translocation of cleaved Bax. ros 113-116 mitogen-activated protein kinase 8 Homo sapiens 144-147 20368806-0 2010 Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation. ros 83-86 mitogen-activated protein kinase 8 Homo sapiens 105-108 20368806-11 2010 CONCLUSIONS/SIGNIFICANCE: Considering that loss of tumor suppressor beclin 1 is associated with neoplasia, the ability of this small molecule compound to engage both autophagic and apoptotic machineries via ROS production and subsequent activation of ERK and JNK could have potential translational implications. ros 207-210 mitogen-activated protein kinase 8 Homo sapiens 259-262 19780038-4 2010 Notexin-induced cell death, mitochondrial depolarization, and ROS generation were suppressed by SB202190 (p38 MAPK inhibitor) and SP600125 (JNK inhibitor). ros 62-65 mitogen-activated protein kinase 8 Homo sapiens 140-143 23416140-8 2013 In conclusion, the JNK and p38 MAPK pathways might be critical mediators in CPF-induced neuronal apoptosis by both generating ROS and up-regulating COX-2. ros 126-129 mitogen-activated protein kinase 8 Homo sapiens 19-22 23220614-10 2013 These results demonstrated for the first time that ISO induces apoptosis in HepG2 cells through inactivating ERK1/2 kinase and activating JNK and p38 kinases, and ROS stimulated by ISO is able to activate the MAPK singaling pathway as the upstream signaling molecules. ros 163-166 mitogen-activated protein kinase 8 Homo sapiens 138-141 21882190-9 2012 HG promoted phosphorylation of ERK1/2, JNK and p38 MAP kinases, which was abrogated by an ROS inhibitor. ros 90-93 mitogen-activated protein kinase 8 Homo sapiens 39-42 22285910-0 2012 Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. ros 31-34 mitogen-activated protein kinase 8 Homo sapiens 44-47 22285910-6 2012 Vinca alkaloids and nocodazole caused glutathione/reactive oxygen species (ROS) imbalance, and inhibiting ROS prevented prolonged JNK activation, decreased Mcl-1 levels, MTP loss, and apoptosis. ros 106-109 mitogen-activated protein kinase 8 Homo sapiens 130-133 22285910-9 2012 These results demonstrate an essential role of ROS in vinca alkaloid-induced aberrant JNK-mediated Mcl-1 downregulation and DNA damage followed by mitochondrial dysfunction-related apoptosis but not mitotic arrest. ros 47-50 mitogen-activated protein kinase 8 Homo sapiens 86-89 21453688-0 2011 Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells. ros 65-68 mitogen-activated protein kinase 8 Homo sapiens 87-90 19700217-5 2010 The release of calcium triggered the production of ROS, which further enhances calcium overloading and subsequently activates p38, JNK and ERK1/2. ros 51-54 mitogen-activated protein kinase 8 Homo sapiens 131-134 18983820-2 2008 Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-Jun N-terminal Kinase1 (JNK1) is indispensable for TGF-beta1-induced apoptosis pathway, but the relationship between radical oxygen species (ROS) and the activation of JNKs is still unclear. ros 217-220 mitogen-activated protein kinase 8 Homo sapiens 74-98 18767140-10 2009 Early-stage JNK activation is solely ROS-dependent, whereas late-stage activation is dependent on ROS-mediated caspase activity, and regulated by caspase-induced activation of PAK2. ros 37-40 mitogen-activated protein kinase 8 Homo sapiens 12-15 18983820-2 2008 Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-Jun N-terminal Kinase1 (JNK1) is indispensable for TGF-beta1-induced apoptosis pathway, but the relationship between radical oxygen species (ROS) and the activation of JNKs is still unclear. ros 217-220 mitogen-activated protein kinase 8 Homo sapiens 100-104 18983820-3 2008 In the present study, we found that ROS can induce JNK activation in TGF-beta1 mediated apoptosis in hepatocytes. ros 36-39 mitogen-activated protein kinase 8 Homo sapiens 51-54 15908180-8 2005 Collectively, these data demonstrate that TNF-alpha/IFN-gamma synergistically activates JNK/SAPK, playing an important role in promoting apoptosis of pancreatic beta-cell via activation of p53 pathway together with ROS. ros 215-218 mitogen-activated protein kinase 8 Homo sapiens 88-96 17707342-8 2007 Taken together, our observations suggest genipin signaling to apoptosis of PC3 cells is mediated via activation of ROS-dependent MLK3, which leads to downstream activation of JNK. ros 115-118 mitogen-activated protein kinase 8 Homo sapiens 175-178 17005604-10 2007 p38 and JNK stimulation by CML-collagen was almost entirely blocked when formation of ROS was inhibited and was partially reduced by NO and ceramide inhibitors. ros 86-89 mitogen-activated protein kinase 8 Homo sapiens 8-11 15908180-0 2005 Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway. ros 122-125 mitogen-activated protein kinase 8 Homo sapiens 26-34 18695917-9 2008 These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations. ros 267-270 mitogen-activated protein kinase 8 Homo sapiens 131-134 17707342-1 2007 It has been reported that genipin, the aglycone of geniposide, induces apoptotic cell death in human hepatoma cells via a NADPH oxidase-reactive oxygen species (ROS)-c-Jun NH(2)-terminal kinase (JNK)-dependent activation of mitochondrial pathway. ros 161-164 mitogen-activated protein kinase 8 Homo sapiens 195-198 15908180-3 2005 Additionally, cells transfected with wild-type JNK1 became more susceptible to apoptosis induced by TNF-alpha/IFN-gamma through ROS production and loss of delta psi m, while cascading apoptotic events were prevented in dominant-negative JNK1-transfected or JNK inhibitor SP600125-treated cells. ros 128-131 mitogen-activated protein kinase 8 Homo sapiens 47-51 12663441-5 2003 Furthermore, Ang II induced a robust phosphorylation of p38MAPK, ERK1/2, and JNK1/2 (particularly JNK2), which was hindered by inhibitors of NADPH oxidase, tyrosine kinases, and ROS scavengers. ros 178-181 mitogen-activated protein kinase 8 Homo sapiens 77-83 15908180-3 2005 Additionally, cells transfected with wild-type JNK1 became more susceptible to apoptosis induced by TNF-alpha/IFN-gamma through ROS production and loss of delta psi m, while cascading apoptotic events were prevented in dominant-negative JNK1-transfected or JNK inhibitor SP600125-treated cells. ros 128-131 mitogen-activated protein kinase 8 Homo sapiens 47-50 15908180-7 2005 This synergistic activation of JNK/SAPK by TNF-alpha/IFN-gamma was also induced in insulin-expressing pancreatic islet cells, and increased ROS production and p53 level, which was significantly inhibited by SP600125. ros 140-143 mitogen-activated protein kinase 8 Homo sapiens 31-34 15581626-4 2004 Those ROS and lipid peroxides were both involved in TNFalpha-induced apoptosis, whereas only ROS elevation triggered sustained JNK activation. ros 93-96 mitogen-activated protein kinase 8 Homo sapiens 127-130 14614324-8 2003 Together, these findings support a model in which induction of apoptosis in Bcr/Abl+ cells by HDIs involves coordinate inactivation of the cytoprotective Raf/MEK/ERK pathway in conjunction with the ROS-dependent activation of JNK. ros 198-201 mitogen-activated protein kinase 8 Homo sapiens 226-229 15197348-5 2004 The reduction in cell growth and enhancement in cell killing by the combination of GST-MDA-7 and radiation were blocked by an ROS scavenger, N-acetyl cysteine (NAC), a JNK1/2/3 inhibitor SP600125, a pan-caspase inhibitor (zVAD) and by an inhibitor of caspase 9 (LEHD), but not by an inhibitor of caspase 8 (IETD). ros 126-129 mitogen-activated protein kinase 8 Homo sapiens 168-176 15130759-12 2004 However, JNK activation by ROS is not involved in the tetrandrine-induced apoptosis. ros 27-30 mitogen-activated protein kinase 8 Homo sapiens 9-12 12599206-5 2003 In particular, ROS recruited p38MAPK and JNK pathways. ros 15-18 mitogen-activated protein kinase 8 Homo sapiens 41-44 34896468-0 2022 Curcin C inhibit osteosarcoma cell line U2OS proliferation by ROS induced apoptosis, autophagy and cell cycle arrest through activating JNK signal pathway. ros 62-65 mitogen-activated protein kinase 8 Homo sapiens 136-139 12151316-8 2002 Herein we present a novel action of proteasome inhibitors, possibly through ROS production, of targeting the upstream signaling molecules, ERK and JNK, which leads to AP-1 activation and IL-8 gene expression. ros 76-79 mitogen-activated protein kinase 8 Homo sapiens 147-150 10531389-5 1999 In conclusion, DNR-triggered apoptosis implicates a ceramide-mediated, ROS-dependent JNK and activated protein-1 activation. ros 71-74 mitogen-activated protein kinase 8 Homo sapiens 85-88 33939975-0 2021 A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways. ros 49-52 mitogen-activated protein kinase 8 Homo sapiens 95-98 11360927-8 2001 Thus, overall, these results show that PDTC induces apoptosis and suggest that JNK/SAPK and subsequent AP-1 activation may be involved in the apoptotic pathway in ROS 17/2.8 osteoblasts. ros 163-166 mitogen-activated protein kinase 8 Homo sapiens 79-87 34634178-12 2022 Odoroside A and its derivative inhibited the growth of leukaemia by inducing apoptosis and autophagy through the activation of ROS-JNK pathway. ros 127-130 mitogen-activated protein kinase 8 Homo sapiens 131-134 34902437-12 2022 Furthermore, gene expression studies indicate that PSTi8 treatment reduces NADPH oxidase3 (NOX3) expression and inhibits JNK signaling, a predominant source of ROS-induced insulin resistance. ros 160-163 mitogen-activated protein kinase 8 Homo sapiens 121-124 34902437-13 2022 SIGNIFICANCE: To summarize, the protective effect of PSTi8 on FFA-induced insulin resistance is mediated via inhibition of JNK signaling, which leads to decreased ROS generation and enhanced insulin sensitivity. ros 163-166 mitogen-activated protein kinase 8 Homo sapiens 123-126 34940569-5 2021 Mechanistically, l-THP promotes the autophagic response by activating the AMPK-mTOR-ULK1 and the ROS-JNK-ATG cascades and impairing the ERK/AKT signaling. ros 97-100 mitogen-activated protein kinase 8 Homo sapiens 101-104 34863979-5 2022 NOX4-stimulated ROS generation led to JNK-mediated phosphorylation of cytosolic HuR at Ser221, thereby increasing TNF-alpha protein expression by stabilizing TNF-alpha mRNA. ros 16-19 mitogen-activated protein kinase 8 Homo sapiens 38-41 34715512-16 2021 The phytochemical significantly altered IR with enhanced glucose uptake and inhibition of ROS through JNK-AKT/mTOR signaling which may pave the way for further research in T2DM therapeutics. ros 90-93 mitogen-activated protein kinase 8 Homo sapiens 102-105 34332981-0 2021 Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells. ros 79-82 mitogen-activated protein kinase 8 Homo sapiens 83-86 34681736-5 2021 ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 115-136 34681736-5 2021 ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 138-141 34274415-6 2021 Our results demonstrated that cisplatin concurrently induced apoptosis and autophagy in OSCC cell lines partially through the ROS/JNK pathway. ros 126-129 mitogen-activated protein kinase 8 Homo sapiens 130-133 34332981-9 2021 Furthermore, we found that the ROS-JNK pathway was obviously activated in the DCA combined sorafenib group. ros 31-34 mitogen-activated protein kinase 8 Homo sapiens 35-38 34369076-8 2021 In conclusion, the study suggests that GSDME triggered DOX-induced pyroptosis in the caspase-3 dependent reactions through the ROS/JNK signalling pathway. ros 127-130 mitogen-activated protein kinase 8 Homo sapiens 131-134 35583119-5 2022 CNPs significantly increased the level of ROS to regulate ERK/JNK signaling, which would further induce resistant cell apoptosis. ros 42-45 mitogen-activated protein kinase 8 Homo sapiens 62-65 35198445-6 2022 The phosphorylation of JNK induced by IHZ-1 was reversed by the decreased ROS level. ros 74-77 mitogen-activated protein kinase 8 Homo sapiens 23-26 35594653-5 2022 ROS activates the c-Jun N-terminal kinase (JNK) pathway to induce mitochondrial-mediated apoptosis. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 18-41 35594653-5 2022 ROS activates the c-Jun N-terminal kinase (JNK) pathway to induce mitochondrial-mediated apoptosis. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 43-46 35198445-8 2022 Our findings suggest that the activation of JNK by IHZ-1 treatment is dependent on the generation of ROS that mediates apoptosis and autophagy in hepatocellular carcinoma. ros 101-104 mitogen-activated protein kinase 8 Homo sapiens 44-47 35100653-6 2022 The binding resulted in the generation of ROS, which consequently activated the oxidative stress-related cell cycle arrest and apoptotic pathways, viz., JNK/p38, p21Cip1/Chk1, and p21Cip1/Rb/E2F, as shown by microarray profiling. ros 42-45 mitogen-activated protein kinase 8 Homo sapiens 153-156 33792698-0 2021 The disulfiram/copper complex induces apoptosis and inhibits tumor growth in human osteosarcoma by activating the ROS/JNK signaling pathway. ros 114-117 mitogen-activated protein kinase 8 Homo sapiens 118-121 35204104-8 2022 UVB-induced ROS production mediated Akt and mitogen activated protein kinases (MAPKs) pathways, including p38, ERK, and JNK. ros 12-15 mitogen-activated protein kinase 8 Homo sapiens 120-123 35052632-7 2022 Our results showed that NAP treatment prevents ROS formation by reducing UV-B-irradiation-induced apoptotic cell death and JNK signalling pathway activation. ros 47-50 mitogen-activated protein kinase 8 Homo sapiens 123-126 33932472-4 2021 Using Caco-2 as a cell model of the intestinal epithelial barrier (the first line of defense against mycotoxins), we showed that a strong production of ROS-dependent CXCL17 was triggered by mycotoxins via p38 and JNK pathways. ros 152-155 mitogen-activated protein kinase 8 Homo sapiens 213-216 33792698-7 2021 The underlying mechanism of this process was explored, and DSF/Cu may mainly inhibit osteosarcoma by inducing apoptosis by activating the ROS/JNK pathway. ros 138-141 mitogen-activated protein kinase 8 Homo sapiens 142-145 32640963-11 2021 CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer. ros 52-55 mitogen-activated protein kinase 8 Homo sapiens 97-100 33189448-7 2021 After blocking the corresponding pathway, it was found that ROS mediates ASK1 and JNK activation. ros 60-63 mitogen-activated protein kinase 8 Homo sapiens 82-85 33194716-9 2020 Taken together, Cos exerted autophagic and apoptotic effects on renal cancer through the ROS/JNK-dependent signal route. ros 89-92 mitogen-activated protein kinase 8 Homo sapiens 93-96 33097606-0 2020 Mitochondrial dysfunction triggers catabolic response in chondrocytes via ROS mediated activation of JNK/AP1 pathway. ros 74-77 mitogen-activated protein kinase 8 Homo sapiens 101-104 33243299-0 2020 Correction to: Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells. ros 68-71 mitogen-activated protein kinase 8 Homo sapiens 82-85 33035517-10 2020 Moreover, morusin treatment strikingly enhanced intracellular ROS level, an ROS scavenger NAC blocked cell death and changes of Akt, JNK and ERK induced by morusin. ros 76-79 mitogen-activated protein kinase 8 Homo sapiens 133-136 33364504-6 2020 ROS triggered JNK and ERK phosphorylation, and cyt c release outside mitochondria, not accompanied by caspases-9 and -3 activation, probably due to 3BP-dependent alkylation of cysteine residues at caspase-9 catalytic site. ros 0-3 mitogen-activated protein kinase 8 Homo sapiens 14-17 32451640-4 2020 Furthermore, PBM could activate mitochondrial ROS, which could elevate the phosphorylation levels of JNK and IKB in HGMSCs, and further activate NF-kappaB as the nuclear translocation of p65 is elevated. ros 46-49 mitogen-activated protein kinase 8 Homo sapiens 101-104 33193889-8 2020 Surfactin-induced mitochondrial-derived ROS generation was associated with JNK1/2 activation. ros 40-43 mitogen-activated protein kinase 8 Homo sapiens 75-81 33193889-9 2020 After treatment with surfactin, ROS caused JNK1/2-dependent cell death of SCC4 and SCC25 cells. ros 32-35 mitogen-activated protein kinase 8 Homo sapiens 43-49 32738660-4 2020 We found that, compared to the non-biomimetic SeHANs, the B-SeHANs exhibited highly enhanced cellular internalization and intracellular degradation, and induced subsequent autophagy and caspase-dependent apoptosis via the ROS-mediated activation of the JNK pathway and inhibition of the Akt/mTOR pathway. ros 222-225 mitogen-activated protein kinase 8 Homo sapiens 253-256 32985606-7 2020 Notably, all these events were reverted by N-acetyl-L-cysteine and JNK inhibitor SP600125 furnishing evidence that APE exerted its effects through the activation of ROS/JNK signaling. ros 165-168 mitogen-activated protein kinase 8 Homo sapiens 67-70 32985606-7 2020 Notably, all these events were reverted by N-acetyl-L-cysteine and JNK inhibitor SP600125 furnishing evidence that APE exerted its effects through the activation of ROS/JNK signaling. ros 165-168 mitogen-activated protein kinase 8 Homo sapiens 169-172 32157127-4 2020 Specifically, after downregulation of the complex I subunit ND-49 (mammalian NDUFS2), TOR activates JNK to induce cell death and ROS production essential for the stimulation of compensatory apoptosis-induced proliferation within the tissue. ros 129-132 mitogen-activated protein kinase 8 Homo sapiens 100-103 33013353-0 2020 Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca+2 Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells. ros 86-89 mitogen-activated protein kinase 8 Homo sapiens 14-17 32708333-6 2020 We further elucidated the mechanism of action of necroptosis via receptor interacting protein kinase 3 (RIPK3) protein expression and it has been attributed by ROS generation through JNK activation. ros 160-163 mitogen-activated protein kinase 8 Homo sapiens 183-186 32619557-0 2020 Synergistic therapy with tangeretin and 5-fluorouracil accelerates the ROS/JNK mediated apoptotic pathway in human colorectal cancer cell. ros 71-74 mitogen-activated protein kinase 8 Homo sapiens 75-78 32370057-0 2020 Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4. ros 71-74 mitogen-activated protein kinase 8 Homo sapiens 98-101 31629709-6 2020 Moreover, schisantherin A induced ROS-dependent JNK phosphorylation with higher ROS production. ros 34-37 mitogen-activated protein kinase 8 Homo sapiens 48-51 32092796-12 2020 These results indicated that increased miR-34c mediated synaptic and memory deficits by targeting SYT1 through ROS-JNK-p53 pathway and the miR-34c/SYT1 pathway could be considered as a promising novel therapeutic target for patients with AD. ros 111-114 mitogen-activated protein kinase 8 Homo sapiens 115-118 32121012-11 2020 We suggest that the antitumor effect of A. hirsuta extract is achieved by apoptosis promotion and cell cycle arrest mediated by the activation of JNK and p38 signaling pathway via ROS generation. ros 180-183 mitogen-activated protein kinase 8 Homo sapiens 146-149 31695327-8 2019 Subsequently, intracellular hydrogen peroxide (H2O2) and the activation of ROS/JNK pathway were detected. ros 75-78 mitogen-activated protein kinase 8 Homo sapiens 79-82