PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20368800-0 2010 Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase. ros 84-87 NLR family pyrin domain containing 3 Homo sapiens 37-42 20368800-6 2010 The ability of Aspergillus hyphae to activate the NLRP3 inflammasome in the monocytes requires K(+) efflux and ROS production. ros 111-114 NLR family pyrin domain containing 3 Homo sapiens 50-55 20201014-4 2010 Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation. ros 29-32 NLR family pyrin domain containing 3 Homo sapiens 49-54 20201014-4 2010 Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation. ros 29-32 NLR family pyrin domain containing 3 Homo sapiens 55-60 20201014-4 2010 Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation. ros 29-32 NLR family pyrin domain containing 3 Homo sapiens 121-126 20201014-4 2010 Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation. ros 29-32 NLR family pyrin domain containing 3 Homo sapiens 127-132 34387860-4 2021 Upon NLRP3 activation, AKT activity is inhibited by second stimulus-induced ROS. ros 76-79 NLR family pyrin domain containing 3 Homo sapiens 5-10 34384953-11 2021 CONCLUSIONS: AZD8055 ameliorated EAE through anti-inflammatory and anti-pyroptosis effects via the mammalian target of mTOR/ROS/NLRP3 pathway. ros 124-127 NLR family pyrin domain containing 3 Homo sapiens 128-133 34854954-8 2022 Moreover, we found that ROS inhibition via NAC effectively blocks NLRP3 activation and pyroptosis. ros 24-27 NLR family pyrin domain containing 3 Homo sapiens 66-71 34987391-8 2021 Furthermore, methyl gallate inhibited the assembly of NLRP3 inflammasomes by blocking the ROS over-generation and oligomerization of NLRP3. ros 90-93 NLR family pyrin domain containing 3 Homo sapiens 54-59 34173812-8 2021 Fisetin could also ameliorate and reduce oxLDL-induced upregulation of SREBP-1 and thereby expression of its downstream liposynthesis genes HMGCR and FAS via inhibiting ROS-induced NLRP3 activation. ros 169-172 NLR family pyrin domain containing 3 Homo sapiens 181-186 34217685-4 2021 Moreover, luteolin was found to significantly reduce the expression of NLRP3, pro-CASP-1 and CASP-1, which are the key components of NLRP3 inflammasome, as well as the expression of N-GSDMD and IL-1beta, and we proved that the inhibition of luteolin on NLRP3 inflammasome activation is ROS-dependent. ros 286-289 NLR family pyrin domain containing 3 Homo sapiens 253-258 35629435-0 2022 Translational Medicine in Uremic Vascular Calcification: Scavenging ROS Attenuates p-Cresyl Sulfate-Activated Caspase-1, NLRP3 Inflammasome and Eicosanoid Inflammation in Human Arterial Smooth Muscle Cells. ros 68-71 NLR family pyrin domain containing 3 Homo sapiens 121-126 34307357-8 2021 In addition, mitochondrial dysfunction may amplify the activation of NLRP3 through the production of mitochondrial ROS, which together aggravate accumulating mitochondrial damage. ros 115-118 NLR family pyrin domain containing 3 Homo sapiens 69-74 35278669-7 2022 ATRA also blocked autophagic flow by activating the AKT/mTOR pathway, leading to an excessive accumulation of ROS, which further activated the NLRP3 inflammasome. ros 110-113 NLR family pyrin domain containing 3 Homo sapiens 143-148 34118452-4 2021 Accumulation of damaged ROS-generating mitochondria, accompanied by the release of mitochondrial DAMPs, can activate PRRs such as the NLRP3 inflammasome, TLR9, cGAS/STING, and ZBP1. ros 24-27 NLR family pyrin domain containing 3 Homo sapiens 134-139 35346830-9 2022 This study showed that miR-1656 could increase the release of ROS by targeting GPX4, activated the NLRP3 inflammasome, and release the inflammatory factors IL-1beta and IL-18 to trigger pyroptosis in the kidney tissue of Se-deficient broilers. ros 62-65 NLR family pyrin domain containing 3 Homo sapiens 99-104 35629435-10 2022 From bedside to bench, ROS scavenger attenuates PCS-activated expressions of cPLA2/COX2, pro-caspase-1 and NLRP3 in the HASMC model. ros 23-26 NLR family pyrin domain containing 3 Homo sapiens 107-112 35138513-5 2022 Moreover, TGF-beta increased the expression of p-Smad2/3-NOX4 in LX-2 cells and consequently increased ROS content, which is a trigger for NLRP3 inflammasome activation. ros 103-106 NLR family pyrin domain containing 3 Homo sapiens 139-144 35171697-5 2022 The NLRP3 inflammasome can be activated by multiple stimuli such as extracellular ATP, microbial toxins, ROS, mitochondria DNA or particulate matter. ros 105-108 NLR family pyrin domain containing 3 Homo sapiens 4-9 35286219-6 2022 Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner. ros 105-108 NLR family pyrin domain containing 3 Homo sapiens 39-44 34011928-0 2021 Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis. ros 130-133 NLR family pyrin domain containing 3 Homo sapiens 134-139 35023144-0 2022 ROS-NLRP3 signaling pathway induces sterile inflammation after thulium laser resection of the prostate. ros 0-3 NLR family pyrin domain containing 3 Homo sapiens 4-9 35023144-2 2022 This study mainly focuses on the role of the reactive oxygen species-NLR family, pyrin domain-containing 3 (ROS-NLRP3) signaling pathway in SI after thulium laser resection of the prostate (TmLRP). ros 108-111 NLR family pyrin domain containing 3 Homo sapiens 112-117 35023144-9 2022 After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC. ros 141-144 NLR family pyrin domain containing 3 Homo sapiens 48-53 35023144-12 2022 Activation of the ROS-NLRP3 signaling pathway induces SI in the wound after prostatectomy. ros 18-21 NLR family pyrin domain containing 3 Homo sapiens 22-27 35132157-6 2022 In contrast, conditioned medium from UPEC-infected NLRP3 knockdown cells significantly decreased the phagocytosis of CFT073 and significantly increased the ROS production from neutrophils. ros 156-159 NLR family pyrin domain containing 3 Homo sapiens 51-56 33845232-4 2021 Further mechanistic study indicated that compound 40 inhibited the NLRP3 inflammasome activation via suppressing ROS production. ros 113-116 NLR family pyrin domain containing 3 Homo sapiens 67-72 35219847-0 2022 Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway. ros 67-70 NLR family pyrin domain containing 3 Homo sapiens 71-76 35098371-9 2022 Overall, PARP-1 positively regulates NLRP3 inflammasome activation via increasing ROS production and interaction with TXNIP and NLRP3, leading to PARylation of NLRP3. ros 82-85 NLR family pyrin domain containing 3 Homo sapiens 37-42 35098371-9 2022 Overall, PARP-1 positively regulates NLRP3 inflammasome activation via increasing ROS production and interaction with TXNIP and NLRP3, leading to PARylation of NLRP3. ros 82-85 NLR family pyrin domain containing 3 Homo sapiens 160-165 35154136-0 2022 Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis. ros 8-11 NLR family pyrin domain containing 3 Homo sapiens 20-25 32103437-6 2020 Moreover, measurement by confocal microscopy and flow cytometry assay indicates that Ti ions can promote the production of ROS, while NLRP3 expression and IL-1beta secretion are reduced after treatment of Jurkat cells with NAC (ROS scavenger). ros 228-231 NLR family pyrin domain containing 3 Homo sapiens 134-139 33967625-12 2021 In vitro experiments revealed that Xi Lei San could repress apoptosis as well as ROS and inflammatory cytokine production in TNF-alpha-induced CACO2 cells by reducing the activity of NLRP3 inflammasomes and autophagy. ros 81-84 NLR family pyrin domain containing 3 Homo sapiens 183-188 33729569-10 2021 RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner. ros 154-157 NLR family pyrin domain containing 3 Homo sapiens 104-109 33720048-6 2021 Mechanistically, caspase-1 activation closely correlated with the inflammatory marker expression and was shown to occur through NLRP3 inflammasome activation driven by virus-dependent and/or -independent ROS production, while caspase-3 activation in CD4+ T cells was more closely related to T cell activation status. ros 204-207 NLR family pyrin domain containing 3 Homo sapiens 128-133 33213267-5 2021 As a result, the accumulation of damaged, ROS-generating mitochondria leads to activation of the NLRP3 inflammasome, which induces abnormal soluble cytokines secretion, then promotes the differentiation and maturation of osteoclasts, and ultimately results in bone metastasis. ros 42-45 NLR family pyrin domain containing 3 Homo sapiens 97-102 32805340-5 2020 When HepG2 cells were pretreated with ROS (NAC) and ERS (4-PBA) inhibitors separately, the activation of NLRP3 inflammasome was inhibited. ros 38-41 NLR family pyrin domain containing 3 Homo sapiens 105-110 33004801-5 2020 Mechanistically, BAFF activated NLRP3 inflammasomes by promoting the association of cIAP-TRAF2 with components of NLRP3 inflammasomes, and by inducing Src activity-dependent ROS production and potassium ion efflux. ros 174-177 NLR family pyrin domain containing 3 Homo sapiens 32-37 32128601-6 2020 Also, apelin protects against ALI/ARDS by reducing mitochondrial ROS-triggered oxidative damage, mitochondria apoptosis, and inflammatory responses induced by the activation of NF-kappaB and NLRP3 inflammasome. ros 65-68 NLR family pyrin domain containing 3 Homo sapiens 191-196 33383234-0 2021 Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway. ros 107-110 NLR family pyrin domain containing 3 Homo sapiens 111-116 33318544-7 2020 Furthermore, inhibition of caspase-1 and NLRP3 activation increased neutrophil ROS-production, phagocytosis and the ability of neutrophils to suppress UPEC growth. ros 79-82 NLR family pyrin domain containing 3 Homo sapiens 41-46 32791262-7 2020 Moreover, NLRP3 siRNA shifted FeCl2-treated microglia from the M1 to the M2 cells, revealing that MitoQ-induce polarization states may be mediated by the mitochondrial ROS/NLRP-3 pathway. ros 168-171 NLR family pyrin domain containing 3 Homo sapiens 10-15 32716363-5 2020 beta-Glucan acted upstream of the NLRP3 inflammasome by preventing potassium (K+) efflux, mitochondrial ROS (mtROS) generation, and, ultimately, apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and speck formation. ros 104-107 NLR family pyrin domain containing 3 Homo sapiens 34-39 32103437-7 2020 Taken together, we presently show that Ti ions can activate NLRP3 inflammasome and then promote IL-beta secretion in vitro, where ROS may play a mechanistic role in this activation process. ros 130-133 NLR family pyrin domain containing 3 Homo sapiens 60-65 30878009-0 2019 The effects of cooking oil fumes-derived PM2.5 on blood vessel formation through ROS-mediated NLRP3 inflammasome pathway in human umbilical vein endothelial cells. ros 81-84 NLR family pyrin domain containing 3 Homo sapiens 94-99 32272506-0 2020 Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS. ros 143-146 NLR family pyrin domain containing 3 Homo sapiens 47-52 32272506-5 2020 Our results demonstrate that BBR and mitochondrion-targeted superoxide dismutase mimetic (Mito-TEMPO; a specific mitochondrial ROS scavenger) significantly restricted NLRP3 inflammasome activation, increased mitochondrial membrane potential (MMP), and decreased mitochondrial ROS (mtROS) generation in J774A.1 macrophages infected with PR8 influenza virus. ros 127-130 NLR family pyrin domain containing 3 Homo sapiens 167-172 32272506-11 2020 Taken together, these findings suggest that restricting NLRP3 inflammasome activation by decreasing ROS generation through mitophagy induction may be crucial for the BBR-mediated alleviation of influenza virus-induced inflammatory lesions. ros 100-103 NLR family pyrin domain containing 3 Homo sapiens 56-61 31485193-0 2019 RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose. ros 50-53 NLR family pyrin domain containing 3 Homo sapiens 54-59 31485193-1 2019 Background: Hyperglycemia plays a vital role in diabetic nephropathy (DN); autophagy and its potential upregulator receptor-interacting protein kinase 2 (RIPK2) are associated with ROS, which play a potential role in regulating NLRP3, and may be involved in inflammation in DN. ros 181-184 NLR family pyrin domain containing 3 Homo sapiens 228-233 31485193-2 2019 Aim: In this study, we aimed to explore the mechanisms mediated by RIPK2 in autophagy and the relationship with ROS-NLRP3 of DN, by investigating the levels of RIPK2 and autophagy in glomerular mesangial cells (GMCs) stimulated with high glucose. ros 112-115 NLR family pyrin domain containing 3 Homo sapiens 116-121 31485193-10 2019 RIPK2 regulates ROS-NLRP3 inflammasome signaling through autophagy and may be involved in the pathogenesis of DN. ros 16-19 NLR family pyrin domain containing 3 Homo sapiens 20-25 32432601-0 2020 Pelargonidin ameliorates CCl4-induced liver fibrosis by suppressing the ROS-NLRP3-IL-1beta axis via activating the Nrf2 pathway. ros 72-75 NLR family pyrin domain containing 3 Homo sapiens 76-81 32328491-3 2020 However, pathways triggering NLRP3 activation, such as potassium efflux, ROS production or lysosomal permeabilization, can be required or not, depending on the activators used. ros 73-76 NLR family pyrin domain containing 3 Homo sapiens 29-34 32057231-4 2020 Ultrasmall (4.5 nm) Au nanoparticles (Au4.5) activate the NLRP3 inflammasome through directly penetrating into cell cytoplasm to promote robust ROS production and target autophagy protein-LC3 (microtubule-associated protein 1-light chain 3) for proteasomal degradation in an endocytic/phagocytic-independent manner. ros 144-147 NLR family pyrin domain containing 3 Homo sapiens 58-63 31706245-11 2020 Our study proved that COFs-derived PM2.5 could damage the tubule formation of HUVECs in vitro, which could be effectively rescue by co-incubation with VD3, in which processes the ROS/NLRP3/VEGF signaling pathway played a crucial role. ros 179-182 NLR family pyrin domain containing 3 Homo sapiens 183-188 31521245-0 2019 Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis. ros 92-95 NLR family pyrin domain containing 3 Homo sapiens 96-101 31521245-7 2019 Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE-treated ECs. ros 61-64 NLR family pyrin domain containing 3 Homo sapiens 99-104 31521245-7 2019 Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE-treated ECs. ros 61-64 NLR family pyrin domain containing 3 Homo sapiens 177-182 31521245-12 2019 In conclusion, our study generated two novel findings, (i) CS activates ROS/NLRP3 axis and induces EC pyroptosis; (ii) melatonin attenuates CS-induced EC pyroptosis by inhibiting ROS/NLRP3 axis. ros 179-182 NLR family pyrin domain containing 3 Homo sapiens 183-188 31485604-0 2019 Overexpression of miR-200a-3p promoted inflammation in sepsis-induced brain injury through ROS-induced NLRP3. ros 91-94 NLR family pyrin domain containing 3 Homo sapiens 103-108 31412804-0 2019 Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux. ros 128-131 NLR family pyrin domain containing 3 Homo sapiens 20-25 31412804-10 2019 Furthermore, we identified that UA regulated the activation of NLRP3 inflammasome by activating ROS and K+ efflux. ros 96-99 NLR family pyrin domain containing 3 Homo sapiens 63-68 31412804-13 2019 CONCLUSIONS: UA could regulate NLRP3/IL-1beta signaling pathway through ROS activation and K+ efflux and further induce vascular endothelial cells injury in early stages of CKD. ros 72-75 NLR family pyrin domain containing 3 Homo sapiens 31-36 30878009-3 2019 Here, to test the role of ROS-mediated NLRP3 inflammasome pathway in blood vessel formation of human umbilical vein endothelial cells (HUVECs) caused by COFs-derived PM2.5, the cells were exposed to COFs-derived PM2.5 at different concentrations with and without N-acetyl-L-cysteine (NAC). ros 26-29 NLR family pyrin domain containing 3 Homo sapiens 39-44 30878009-13 2019 It was revealed that the impact caused by COFs-derived PM2.5 on blood vessel formation through a ROS-mediated NLRP3 inflammasome pathway. ros 97-100 NLR family pyrin domain containing 3 Homo sapiens 110-115 31360100-8 2019 Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages. ros 147-150 NLR family pyrin domain containing 3 Homo sapiens 57-62 31244838-4 2019 NLRP3 activation also depends on NEK7 and mitochondrial ROS-production. ros 56-59 NLR family pyrin domain containing 3 Homo sapiens 0-5 29993075-8 2018 The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1. ros 138-141 NLR family pyrin domain containing 3 Homo sapiens 152-157 30439413-5 2019 We found that cyclo(His-Pro) inhibits NLRP3 inflammasome activation by reducing protein nitration via reduction in NO and ROS levels, indicative of lower peroxynitrite generation by LPS. ros 122-125 NLR family pyrin domain containing 3 Homo sapiens 38-43 30236770-9 2018 The inhibition of ROS production decreased NLRP3 inflammasome activation and IL-1beta production in CD4 T cells, leading to the suppression of Th17 differentiation. ros 18-21 NLR family pyrin domain containing 3 Homo sapiens 43-48 30611121-0 2019 Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells. ros 20-23 NLR family pyrin domain containing 3 Homo sapiens 24-29 30611121-1 2019 PURPOSE: The activation of ROS-NLRP3-IL-1beta signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis. ros 27-30 NLR family pyrin domain containing 3 Homo sapiens 31-36 30611121-8 2019 RESULTS: Calcitriol could protect cells against HS-induced injury through inhibiting ROS-NLRP3-IL-1beta signaling axis. ros 85-88 NLR family pyrin domain containing 3 Homo sapiens 89-94 30217146-8 2018 Moreover, the process of NLRP3 inflammasome activation and IL-1beta production in macrophages in response to T. pallidum infection involves K+ efflux, mitochondrial ROS production and cathepsin release. ros 165-168 NLR family pyrin domain containing 3 Homo sapiens 25-30 29663696-6 2018 In the work reported here, we examined the roles of the different beta-tubulin isotypes in response to glutamate/glycine treatment, and found that both betaII and betaIII bind to glutathione in the presence of ROS, especially betaIII. ros 210-213 NLR family pyrin domain containing 3 Homo sapiens 152-170 29663696-9 2018 In view of the high levels of betaII and betaIII expressed in the nervous system it is conceivable that these tubulin isotypes may use their sulfhydryl groups to scavenge ROS and protect neuronal cells against oxidative stress. ros 171-174 NLR family pyrin domain containing 3 Homo sapiens 30-48 29950247-2 2018 The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS. ros 71-74 NLR family pyrin domain containing 3 Homo sapiens 126-131 29720213-11 2018 ROS was required for PM2.5-induced IL-1beta production and NLRP3 inflammasome activation in oAbeta-stimulated microglia. ros 0-3 NLR family pyrin domain containing 3 Homo sapiens 59-64 29720213-13 2018 CONCLUSIONS: For the first time, these results suggested that the effects of PM2.5 under AD context were possibly mediated by NLRP3 inflammasome activation, which was triggered by ROS. ros 180-183 NLR family pyrin domain containing 3 Homo sapiens 126-131 29098483-0 2018 Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling. ros 114-117 NLR family pyrin domain containing 3 Homo sapiens 118-123 29446486-0 2018 Interleukin-17A participates in podocyte injury by inducing IL-1beta secretion through ROS-NLRP3 inflammasome-caspase-1 pathway. ros 87-90 NLR family pyrin domain containing 3 Homo sapiens 91-96 29446486-8 2018 Blockade of intracellular ROS or inhibition of caspase-1 prevented activation of the NLRP3 inflammasome, thereby restoring podocyte morphology. ros 26-29 NLR family pyrin domain containing 3 Homo sapiens 85-90 29098483-9 2018 Taken together, our results reveal that irisin alleviates AGEs-induced inflammation and endothelial dysfunction via inhibiting ROS-NLRP3 inflammasome signaling, suggest a likely mechanism for irisin-induced therapeutic effect in vascular complications of diabetes. ros 127-130 NLR family pyrin domain containing 3 Homo sapiens 131-136 29063476-0 2018 Fungal beta-Glucan Activates the NLRP3 Inflammasome in Human Bronchial Epithelial Cells Through ROS Production. ros 96-99 NLR family pyrin domain containing 3 Homo sapiens 33-38 29063476-6 2018 Further studies demonstrated that the activation of NLRP3 inflammasome could be attenuated by NAC, an inhibitor of ROS. ros 115-118 NLR family pyrin domain containing 3 Homo sapiens 52-57 29063476-7 2018 Thus, it indicated curdlan activate NLRP3 inflammasome through a pathway requiring ROS production in HBECs. ros 83-86 NLR family pyrin domain containing 3 Homo sapiens 36-41 28583762-0 2017 Puerarin inhibits amyloid beta-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. ros 121-124 NLR family pyrin domain containing 3 Homo sapiens 39-44 28942022-10 2017 In conclusion, our results demonstrate that autophagy-mediated ROS reduction is responsible for X-11-5-27-induced NLRP3 flammasome inactivation. ros 63-66 NLR family pyrin domain containing 3 Homo sapiens 114-119 29057315-8 2017 Furthermore, the pesticides enhanced mitochondrial ROS generation in primary microglia, while amelioration of mitochondria-derived ROS by the mitochondria-targeted antioxidant mito-apocynin completely abolished IL-1beta release, indicating mitochondrial ROS drives potentiation of the NLRP3 inflammasome in microglia. ros 131-134 NLR family pyrin domain containing 3 Homo sapiens 285-290 29057315-8 2017 Furthermore, the pesticides enhanced mitochondrial ROS generation in primary microglia, while amelioration of mitochondria-derived ROS by the mitochondria-targeted antioxidant mito-apocynin completely abolished IL-1beta release, indicating mitochondrial ROS drives potentiation of the NLRP3 inflammasome in microglia. ros 131-134 NLR family pyrin domain containing 3 Homo sapiens 285-290 28583762-5 2017 The results showed that Abeta1-40 induced NLRP3 inflammasome activation mainly via triggering ROS-dependent oxidative stress, particularly lipid peroxidation, and endoplasmic reticulum stress in LPS-primed ARPE-19 cells; however, such effect could be significantly reversed by puerarin in a dose-dependent manner. ros 94-97 NLR family pyrin domain containing 3 Homo sapiens 42-47 27321752-8 2016 These results indicate that in case of HIV infected macrophages exposed to cocaine, increased ROS production and IL-1beta transcription serve as an activators for the formation of NLRP3 and AIM2 mediated inflammasomes that leads to caspase 1 mediated apoptosis. ros 94-97 NLR family pyrin domain containing 3 Homo sapiens 180-185 27250627-16 2016 CONCLUSIONS: Anti-dsDNA Abs activated NLRP3 inflammasome in monocytes/macrophages from SLE patients by binding to TLR4 and inducing the production of mitochondrial ROS. ros 164-167 NLR family pyrin domain containing 3 Homo sapiens 38-43 26102024-0 2015 Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress. ros 72-75 NLR family pyrin domain containing 3 Homo sapiens 85-90 25202950-8 2014 CONCLUSION: ROS induced by free fatty acid can regulate the activation of NALP3 inflammasome signaling pathway leading to the release of inflammatory cytokines. ros 12-15 NLR family pyrin domain containing 3 Homo sapiens 74-79