PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33555513-0	2021	Tropical lichen, Dirinaria consimilis, induces ROS-mediated activation of MAPKs and triggers caspase cascade mediated apoptosis in brain and cervical cancer cells.	ros	47-50	caspase 8	Homo sapiens	93-100	
34330116-14	2021	The mechanism of FA-BSANPs/BA promoting apoptosis of breast cancer may be due to its action on the caspase-8/Bid/ROS pathway.	ros	113-116	caspase 8	Homo sapiens	99-108	
33555513-12	2021	Performed in-depth anticancer study revealed the ROS-mediated regulation of MAP kinases and activation of caspase cascade in U87 and HeLa cells upon DCME treatment.	ros	49-52	caspase 8	Homo sapiens	106-113	
33394232-13	2021	Acacetin and apigenin-induced ROS is responsible for the induction of cell cycle arrest and activation of caspase-cascade pathways in U87 cells.	ros	30-33	caspase 8	Homo sapiens	106-113	
32470830-9	2020	In addition, our data exhibit that both isobutyrylshikonin and shikonin induce caspase-dependent apoptosis via the mitochondrial pathway through accumulation of ROS in oral squamous carcinoma cells.	ros	161-164	caspase 8	Homo sapiens	79-86	
32567066-8	2020	Caspase 8 was activated in cells treated by CPF but accompaniment of PILO with CPF led to activation of caspase 9, 8 and 3 and ROS overproduction.	ros	127-130	caspase 8	Homo sapiens	0-9	
27748905-9	2016	Taken together, our data indicated that 8-ADEQ-stimulated apoptosis in HL-60 leukemia cells is due to a Fas-mediated caspase-8-dependent pathway via ROS generation, but also, to a lesser extent cytochrome c release and caspase-9 activation.	ros	149-152	caspase 8	Homo sapiens	117-126	
30125721-6	2018	The mechanism studies indicated the mitochondrial localization of BODIPY3-PEG3 was able to generate ROS in mitochondria, which further result in mitochondrial dysfunction and photoinduced apoptosis via caspase-8 and caspase-3 pathway.	ros	100-103	caspase 8	Homo sapiens	202-211	
29475156-4	2018	6p also significantly induces both EC9706 and EC109 cell cycle arrest at G0/G1 phase and cell apoptosis, as well as intracellular ROS accumulation, which could be markedly reversed caspase or ROS inhibitor: NAC.	ros	130-133	caspase 8	Homo sapiens	181-188	
27378626-7	2016	Biochemical evidence of apoptosis came from elevating the intracellular ROS level that was accompanied by mitochondrial membrane potential loss, decreasing the expression profile of anti-apoptotic protein Bcl-2, whereas it augments cleavage of caspase-3 and PARP-1, activates caspase-8 and 9 with concomitant increase in expression of proapoptotic protein Bax in a dose dependent manner.	ros	72-75	caspase 8	Homo sapiens	276-285	
26410814-6	2015	The fluorescence intensity of ROS and the activities of Caspase-3, Caspase-8, and Caspase-9 were increased.	ros	30-33	caspase 8	Homo sapiens	67-76	
27268964-8	2016	In addition, an increment in the levels of ROS, caspase-8, -9 and -3 was observed.	ros	43-46	caspase 8	Homo sapiens	48-68	
22739161-8	2012	It is concluded that GA induced apoptosis of Jurkat cells by activated caspases through activating of ROS-CaMKII-MAPKK-JNK/P38 pathway.	ros	102-105	caspase 8	Homo sapiens	71-79	
15197348-5	2004	The reduction in cell growth and enhancement in cell killing by the combination of GST-MDA-7 and radiation were blocked by an ROS scavenger, N-acetyl cysteine (NAC), a JNK1/2/3 inhibitor SP600125, a pan-caspase inhibitor (zVAD) and by an inhibitor of caspase 9 (LEHD), but not by an inhibitor of caspase 8 (IETD).	ros	126-129	caspase 8	Homo sapiens	296-305	
22903547-1	2013	In a recent study, we showed that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two common omega-3 fatty acids, can cause ROS accumulation and subsequently induce caspase-8-dependent apoptosis in human breast cancer cells (Kang et al.	ros	136-139	caspase 8	Homo sapiens	177-186	
21399877-7	2011	In addition, each caspase inhibitor and siRNA differently affects ROS levels including O2 - regardless of cell growth inhibition and cell death levels.	ros	66-69	caspase 8	Homo sapiens	18-25	
12880425-5	2003	Generation of ROS and hyperpolarization of mitochondrial transmembrane potential (DeltaPsim) were early events, followed by increased Fas expression and activation of caspase-8, and then activation of caspase-3 and -9.	ros	14-17	caspase 8	Homo sapiens	167-176