PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11395489-2 2001 Avidin and its bacterial analogue streptavidin exhibit similarly high affinities toward the vitamin biotin. Biotin 92-106 avidin Gallus gallus 0-6 11282023-10 2001 Based on these data, we propose that avidin binds extracellular biotin and regulates cell proliferation by interfering with fatty acid biosynthesis during terminal cell differentiation and/or in response to inflammatory stimuli. Biotin 64-70 avidin Gallus gallus 37-43 1524445-0 1992 Availability of avidin-bound biotin to the chicken embryo. Biotin 29-35 avidin Gallus gallus 16-22 10835608-1 2000 Avidin is a glycoprotein found in chicken egg white, that sequesters the vitamin biotin. Biotin 73-87 avidin Gallus gallus 0-6 9883906-1 1998 Avidin, a positively charged egg-white glycoprotein, is a widely used tool in biotechnological applications because of its ability to bind biotin strongly. Biotin 139-145 avidin Gallus gallus 0-6 9883906-7 1998 Our results demonstrate that the charge properties of avidin can be modified without disturbing the crucial biotin-binding activity. Biotin 108-114 avidin Gallus gallus 54-60 8798877-3 1996 Avidin protein as detected by either immunohistochemistry or binding of streptavidin-biotin complexes was present and functional following transient expression. Biotin 85-91 avidin Gallus gallus 0-6 8798877-7 1996 These experiments establish a means by which avidin gene expression can be explored as a mechanism for targeted gene delivery of biotin-derivitized drugs in vitro, and have important implications for utilization of this strategy in vivo. Biotin 129-135 avidin Gallus gallus 45-51 8026761-4 1994 Our results indicated that, despite the potentially harmful biotin-binding activity of Avd, it is possible to produce biologically active Avd in E. coli which then can easily be purified by affinity chromatography on a biotin column in a single step. Biotin 60-66 avidin Gallus gallus 87-90 8026761-4 1994 Our results indicated that, despite the potentially harmful biotin-binding activity of Avd, it is possible to produce biologically active Avd in E. coli which then can easily be purified by affinity chromatography on a biotin column in a single step. Biotin 219-225 avidin Gallus gallus 138-141 1524445-1 1992 Avidin, an exceptionally stable protein in egg white, binds the vitamin biotin with very high affinity and can induce biotin deficiency when fed to animals. Biotin 72-78 avidin Gallus gallus 0-6 1524445-1 1992 Avidin, an exceptionally stable protein in egg white, binds the vitamin biotin with very high affinity and can induce biotin deficiency when fed to animals. Biotin 118-124 avidin Gallus gallus 0-6 1524445-2 1992 To determine if biotin bound to avidin is available to the chicken embryo, the fate of [3H]biotin complexed to avidin was monitored during embryonic development. Biotin 16-22 avidin Gallus gallus 32-38 1524445-2 1992 To determine if biotin bound to avidin is available to the chicken embryo, the fate of [3H]biotin complexed to avidin was monitored during embryonic development. Biotin 91-97 avidin Gallus gallus 111-117 6329759-1 1984 Avidin, a high-affinity biotin-binding protein of chicken oviduct, was recently found to be synthesized and secreted by damaged or virus-transformed chicken embryo fibroblasts and by chicken macrophages. Biotin 24-30 avidin Gallus gallus 0-6 2422018-8 1986 Avidin induced by theophylline showed heat-induced biotin exchange identical to that of progesterone-induced avidin, indicating close similarity of these proteins. Biotin 51-57 avidin Gallus gallus 0-6 6329759-3 1984 The cells released to the culture medium up to 12 micrograms avidin per 10(6) cells, as judged by the [14C] biotin-binding method. Biotin 108-114 avidin Gallus gallus 61-67 318443-2 1979 The occurrence and inducibility of the biotin-binding egg white protein (avidin) in the chicken is not restricted to the oviduct. Biotin 39-45 avidin Gallus gallus 73-79 6315397-2 1983 Avidin was detectable in both transformed and untransformed cultures, and was identical to chicken egg white avidin by several criteria: biotin-binding, heat-induced biotin exchange, subunit size (mol. Biotin 137-143 avidin Gallus gallus 0-6 6315397-2 1983 Avidin was detectable in both transformed and untransformed cultures, and was identical to chicken egg white avidin by several criteria: biotin-binding, heat-induced biotin exchange, subunit size (mol. Biotin 166-172 avidin Gallus gallus 0-6 6989624-0 1980 Induction of an antimicrobial biotin-binding egg white protein (avidin) in chick tissues in septic Escherichia coli infection. Biotin 30-36 avidin Gallus gallus 64-70 21673170-9 2011 The upregulation of avidin and AVR2 mRNA within the sperm storage region indicates the involvement of avidin, and perhaps avidin analogs, in the sustained storage of sperm in the SST, possibly through the binding of biotin to avidin. Biotin 216-222 avidin Gallus gallus 20-26 25630677-0 2015 Oral administration of supplementary biotin differentially influences the fertility rate and oviductal expression of avidin and avidin-related protein-2 in low- and high-fertility broiler line hens. Biotin 37-43 avidin Gallus gallus 117-123 25630677-2 2015 The high affinity of biotin to avidin and its analogs is also well documented. Biotin 21-27 avidin Gallus gallus 31-37 25630677-10 2015 Real-time PCR data showed that both avidin (P=0.0013) and AVR2 (P<0.0001) expressions were influenced by a biotinxline interaction effect, where low-fertility line B hens receiving the high biotin level recorded respectively a 3.9 and 15.3% increase in avidin and AVR2 mRNA expression, although biotin did not affect these traits in line D hens. Biotin 110-116 avidin Gallus gallus 36-42 25630677-14 2015 Overall, fertility rate and oviductal expression of avidin and AVR2 were dichotomously affected by oral biotin in low- and high-fertility line hens, where only low-fertility birds showed improvements in these attributes. Biotin 104-110 avidin Gallus gallus 52-58 29540428-1 2018 Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. Biotin 81-87 avidin Gallus gallus 0-6 25002549-11 2014 Overall, the effect of biotin supplementation on AVR2 expression, and the relationship between biotin administration and oviductal expression of avidin and AVR2 was dependent on the hen"s age, being higher in the young hens. Biotin 95-101 avidin Gallus gallus 145-151 22392339-0 2013 Resonance assignments of the 56 kDa chimeric avidin in the biotin-bound and free forms. Biotin 59-65 avidin Gallus gallus 45-51 22392339-2 2013 Avidin"s ability to bind biotin with a very high affinity has widely been exploited in biotechnological applications. Biotin 25-31 avidin Gallus gallus 0-6 21673170-9 2011 The upregulation of avidin and AVR2 mRNA within the sperm storage region indicates the involvement of avidin, and perhaps avidin analogs, in the sustained storage of sperm in the SST, possibly through the binding of biotin to avidin. Biotin 216-222 avidin Gallus gallus 102-108 21673170-9 2011 The upregulation of avidin and AVR2 mRNA within the sperm storage region indicates the involvement of avidin, and perhaps avidin analogs, in the sustained storage of sperm in the SST, possibly through the binding of biotin to avidin. Biotin 216-222 avidin Gallus gallus 102-108 21673170-9 2011 The upregulation of avidin and AVR2 mRNA within the sperm storage region indicates the involvement of avidin, and perhaps avidin analogs, in the sustained storage of sperm in the SST, possibly through the binding of biotin to avidin. Biotin 216-222 avidin Gallus gallus 102-108 20233034-4 2010 AREAS COVERED IN THIS REVIEW: Avidin, originally isolated from chicken eggs, and its bacterial analogue, streptavidin, from Streptomyces avidinii, have extremely high affinity for biotin. Biotin 180-186 avidin Gallus gallus 30-36 20233034-5 2010 This unique feature is the basis of avidin-biotin technology. Biotin 43-49 avidin Gallus gallus 36-42 20233034-8 2010 TAKE HOME MESSAGE: Avidin and biotin technology has proved to be an extremely versatile tool with broad applications, such as pretargeting, delivering avidin gene into cells enabling targeting of biotinylated compounds and targeting of viral vectors. Biotin 30-36 avidin Gallus gallus 151-157 20100839-1 2010 Chicken avidin and bacterial streptavidin are widely employed in vitro for their capacity to bind biotin, but their pharmacokinetics and immunological properties are not always optimal, thereby limiting their use in medical treatments. Biotin 98-104 avidin Gallus gallus 8-14 20100839-3 2010 This method allows protection of biotin-binding sites of avidin from inactivation caused by the oxidation step and delay of avidin clearance from injected tissue by generation of aldehyde groups from avidin carbohydrate moieties. Biotin 33-39 avidin Gallus gallus 57-63 20100839-3 2010 This method allows protection of biotin-binding sites of avidin from inactivation caused by the oxidation step and delay of avidin clearance from injected tissue by generation of aldehyde groups from avidin carbohydrate moieties. Biotin 33-39 avidin Gallus gallus 124-130 20100839-3 2010 This method allows protection of biotin-binding sites of avidin from inactivation caused by the oxidation step and delay of avidin clearance from injected tissue by generation of aldehyde groups from avidin carbohydrate moieties. Biotin 33-39 avidin Gallus gallus 124-130 20100839-5 2010 In strict agreement with these results, circular dichroism and isothermal titration calorimetry analyses confirm that the ligand-assisted oxidation preserves the avidin protein structure and its biotin binding capacity. Biotin 195-201 avidin Gallus gallus 162-168 20100839-7 2010 In addition, the efficient uptake of the intravenously injected (111)In-BiotinDOTA (ST2210) in the site previously treated with modified avidin underlines that tissue-bound oxidized avidin retains its biotin binding capacity in vivo. Biotin 201-207 avidin Gallus gallus 137-143 20100839-7 2010 In addition, the efficient uptake of the intravenously injected (111)In-BiotinDOTA (ST2210) in the site previously treated with modified avidin underlines that tissue-bound oxidized avidin retains its biotin binding capacity in vivo. Biotin 201-207 avidin Gallus gallus 182-188