PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10207125-0 1999 Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells. dibenzo(a,l)pyrene 24-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-71 16581046-4 2006 The total turnover of CYP-mediated transformation of DB[a,l]P was as follows: human CYP1B1>fish CYP1A1 approximately human CYP1A1>>rat CYP1A2>rat CYP1A1. dibenzo(a,l)pyrene 53-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 16581046-4 2006 The total turnover of CYP-mediated transformation of DB[a,l]P was as follows: human CYP1B1>fish CYP1A1 approximately human CYP1A1>>rat CYP1A2>rat CYP1A1. dibenzo(a,l)pyrene 53-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 126-132 16581046-8 2006 DB[a,l]P-dependent cytotoxicities (EC(50)) were found in the following order: human CYP1A1 (12 nM)>fish CYP1A1 (30 nM)>human CYP1B1 (45 nM)>>other forms. dibenzo(a,l)pyrene 0-8 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-90 16581046-8 2006 DB[a,l]P-dependent cytotoxicities (EC(50)) were found in the following order: human CYP1A1 (12 nM)>fish CYP1A1 (30 nM)>human CYP1B1 (45 nM)>>other forms. dibenzo(a,l)pyrene 0-8 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 16581046-9 2006 In addition, an appreciable micronuclei formation was detected in human CYP1A1- and 1B1-expressing cells during exposure to DB[a,l]P. dibenzo(a,l)pyrene 124-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 72-78 16581046-10 2006 Our study demonstrates that human CYP1A1, 1B1 and fish CYP1A1 are able to transform DB[a,l]P into genotoxic derivatives in appreciable amounts. dibenzo(a,l)pyrene 84-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-45 16581046-10 2006 Our study demonstrates that human CYP1A1, 1B1 and fish CYP1A1 are able to transform DB[a,l]P into genotoxic derivatives in appreciable amounts. dibenzo(a,l)pyrene 84-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40