PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17623886-0 2007 Inhibition of human cytochrome p450 1b1 further clarifies its role in the activation of dibenzo[a,l]pyrene in cells in culture. dibenzo(a,l)pyrene 88-106 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 20-39 17509623-0 2007 Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1. dibenzo(a,l)pyrene 33-51 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 146-153 16581046-4 2006 The total turnover of CYP-mediated transformation of DB[a,l]P was as follows: human CYP1B1>fish CYP1A1 approximately human CYP1A1>>rat CYP1A2>rat CYP1A1. dibenzo(a,l)pyrene 53-61 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 84-90 16581046-8 2006 DB[a,l]P-dependent cytotoxicities (EC(50)) were found in the following order: human CYP1A1 (12 nM)>fish CYP1A1 (30 nM)>human CYP1B1 (45 nM)>>other forms. dibenzo(a,l)pyrene 0-8 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 131-137 10207125-0 1999 Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells. dibenzo(a,l)pyrene 24-42 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 76-84 10207125-1 1999 Metabolic activation of the strongly carcinogenic polycyclic aromatic hydrocarbon (PAH) dibenzo[a,l]pyrene (DB[a,l]P) and its trans-8,9-dihydrodiol (trans-8,9-diol) catalyzed by human cytochromes P450 (P450) 1A1 and 1B1 was investigated. dibenzo(a,l)pyrene 108-116 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 184-219 9625737-0 1998 Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene. dibenzo(a,l)pyrene 128-146 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-46 9625737-14 1998 These results indicate that human P450 1B1 and P450 1A1 differ in their regio- and stereochemical selectivity of activation of DB[a,l]P with P450 1B1 forming a higher proportion of the highly carcinogenic (-)-anti-(11R, 12S,13S,14R)-DB[a,l]PDE metabolite. dibenzo(a,l)pyrene 127-135 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-55 9625737-14 1998 These results indicate that human P450 1B1 and P450 1A1 differ in their regio- and stereochemical selectivity of activation of DB[a,l]P with P450 1B1 forming a higher proportion of the highly carcinogenic (-)-anti-(11R, 12S,13S,14R)-DB[a,l]PDE metabolite. dibenzo(a,l)pyrene 127-135 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-42 26990437-2 2017 Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, we tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. dibenzo(a,l)pyrene 125-147 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 100-107 26990437-2 2017 Utilizing a mouse model, null for Cyp1b1 and expressing human CYP1B1, we tested the hypothesis that hCYP1B1 is important for dibenzo[def,p]chrysene (DBC) transplacental carcinogenesis. dibenzo(a,l)pyrene 149-152 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 100-107