PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16005925-3 2006 We found that only strong genotoxin dibenzo[a,l]pyrene (DBalP) activated extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38 kinase, but not c-Jun N-terminal kinases (JNKs), at concentrations inducing both apoptosis and phosphorylation of p53 tumor suppressor at serine 15 residue. dibenzo(a,l)pyrene 56-61 mitogen activated protein kinase 14 Rattus norvegicus 133-136 16005925-5 2006 Synthetic inhibitors of ERK1/2 activation (U0126) or p38 kinase activity (SB203580) prevented both apoptosis and induction of p53 phosphorylation by DBalP. dibenzo(a,l)pyrene 149-154 mitogen activated protein kinase 14 Rattus norvegicus 53-56 16005925-7 2006 Taken together, our data suggest that both ERK1/2 and p38 are activated in response to DBalP and that they might be involved in regulation of cellular response to DNA damage induced by DBalP, while neither kinase is involved in the release from contact inhibition induced by PAHs. dibenzo(a,l)pyrene 87-92 mitogen activated protein kinase 14 Rattus norvegicus 54-57 16005925-7 2006 Taken together, our data suggest that both ERK1/2 and p38 are activated in response to DBalP and that they might be involved in regulation of cellular response to DNA damage induced by DBalP, while neither kinase is involved in the release from contact inhibition induced by PAHs. dibenzo(a,l)pyrene 185-190 mitogen activated protein kinase 14 Rattus norvegicus 54-57