PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28675694-7	2016	Western blotting indicated that BITC induced Fas, Fas-L, FADD, caspase-8, caspase -3, and pro-apoptotic protein (Bax, Bid, and Bak), but inhibited the ant-apoptotic proteins (Bcl-2 and Bcl-x) in GBM 8401 cells.	benzyl isothiocyanate	32-36	BCL2 apoptosis regulator	Homo sapiens	175-180	
31817791-6	2019	Western blotting indicated that BITC regulated the expressions of the mitochondria-mediated apoptosis signaling molecules, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), and cytochrome c (Cyt c).	benzyl isothiocyanate	32-36	BCL2 apoptosis regulator	Homo sapiens	123-140	
31817791-6	2019	Western blotting indicated that BITC regulated the expressions of the mitochondria-mediated apoptosis signaling molecules, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein (Bax), and cytochrome c (Cyt c).	benzyl isothiocyanate	32-36	BCL2 apoptosis regulator	Homo sapiens	142-147	
27693243-8	2016	Notably, BITC-induced apoptosis was associated with reduced Mcl-1 and Bcl-2 expression, diminished mitochondrial membrane potential (DeltaPsim), and increased PARP cleavage.	benzyl isothiocyanate	9-13	BCL2 apoptosis regulator	Homo sapiens	70-75	
22359675-11	2012	Interestingly, the BITC-treated MDA-MB-231 cells exhibited induction of Bcl-2 protein expression, and RNA interference of Bcl-2 in this cell line resulted in augmentation of BITC-induced apoptosis.	benzyl isothiocyanate	19-23	BCL2 apoptosis regulator	Homo sapiens	72-77	
22359675-11	2012	Interestingly, the BITC-treated MDA-MB-231 cells exhibited induction of Bcl-2 protein expression, and RNA interference of Bcl-2 in this cell line resulted in augmentation of BITC-induced apoptosis.	benzyl isothiocyanate	174-178	BCL2 apoptosis regulator	Homo sapiens	122-127	
17121941-5	2006	The BITC-induced apoptosis correlated with induction of proapoptotic proteins Bax (MCF-7) and Bak (MDA-MB-231 and MCF-7) and down-regulation of antiapoptotic proteins Bcl-2 and Bcl-xL (MDA-MB-231).	benzyl isothiocyanate	4-8	BCL2 apoptosis regulator	Homo sapiens	167-172	
15026354-0	2004	A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation.	benzyl isothiocyanate	15-36	BCL2 apoptosis regulator	Homo sapiens	134-139	
15026354-7	2004	We reported here for the first time that the antiapoptotic Bcl-2 protein was phosphorylated by the BITC treatment without significant alteration of the Bcl-2 total protein amount.	benzyl isothiocyanate	99-103	BCL2 apoptosis regulator	Homo sapiens	59-64	
15026354-9	2004	Moreover, the spontaneous phosphorylation of antiapoptotic Bcl-2 in the G(2)-M synchronized cells was enhanced synergistically by the BITC treatment.	benzyl isothiocyanate	134-138	BCL2 apoptosis regulator	Homo sapiens	59-64