PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31706900-0 2020 A novel isothiocyanate derivative inhibits HIV-1 gene expression and replication by modulating the nuclear matrix associated protein SMAR1. Isothiocyanates 8-22 BTG3 associated nuclear protein Homo sapiens 133-138 31706900-2 2020 Here, we report for the first time, anti-HIV activity of 8 novel isothiocyanate (ITC) derivatives that differentially stabilise SMAR1. Isothiocyanates 65-79 BTG3 associated nuclear protein Homo sapiens 128-133 31706900-2 2020 Here, we report for the first time, anti-HIV activity of 8 novel isothiocyanate (ITC) derivatives that differentially stabilise SMAR1. Isothiocyanates 81-84 BTG3 associated nuclear protein Homo sapiens 128-133 31706900-9 2020 Taken together, these findings highlight the anti-HIV potential of novel ITC derivatives by the stabilisation of SMAR1 and strongly support further in vivo characterisation and potential translational applications of SCS-OCL-381. Isothiocyanates 73-76 BTG3 associated nuclear protein Homo sapiens 113-118