PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24533814-3 2014 However, most known inducers (e.g., triterpenoids, isothiocyanates and sulfoxythiocarbamates) that activate the ARE system through electrophilic attacks on the cysteine sulfhydryl group of Keap1 also disrupt theKeap1-Nrf2 interaction. Isothiocyanates 51-66 NFE2 like bZIP transcription factor 2 Homo sapiens 217-221 27911093-2 2017 As we reported previously, Wasabi isothiocyanates (ITCs) are activators of Nrf2-antioxidant response element pathway, and also inhibitors of pro-inflammatory cyclooxygenase-2. Isothiocyanates 51-55 NFE2 like bZIP transcription factor 2 Homo sapiens 75-79 27989132-5 2016 Many dietary phytochemicals with cancer chemopreventive properties, such as polyphenols, isothiocyanates, and triterpenoids, exert antioxidant and anti-inflammatory functions by activating the Nrf2 pathway. Isothiocyanates 89-104 NFE2 like bZIP transcription factor 2 Homo sapiens 193-197 26094214-1 2015 Dietary isothiocyanates are potent inducers of the NF-E2-related factor 2 (Nrf2) pathway. Isothiocyanates 8-23 NFE2 like bZIP transcription factor 2 Homo sapiens 51-73 26094214-1 2015 Dietary isothiocyanates are potent inducers of the NF-E2-related factor 2 (Nrf2) pathway. Isothiocyanates 8-23 NFE2 like bZIP transcription factor 2 Homo sapiens 75-79 25800511-7 2015 These results indicate that isothiocyanates/indoles and protocatechuic and tannic acids induce phase II and antioxidant gene expression in HepG2 cells through the Nrf2-Keap1-ARE signaling pathway. Isothiocyanates 28-43 NFE2 like bZIP transcription factor 2 Homo sapiens 163-167 25672622-3 2015 Health-promoting nutrients and other factors act, at least in part by raising Nrf2 including: many phenolic antioxidants; gamma- and delta-tocopherols and tocotrienols; long chain omega-3 fatty acids DHA and EPA; many carotenoids of which lycopene may be the most active; isothiocyanates from cruciferous vegetables; sulfur compounds from allium vegetables; terpenoids. Isothiocyanates 272-287 NFE2 like bZIP transcription factor 2 Homo sapiens 78-82 25593219-1 2015 Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1. Isothiocyanates 46-61 NFE2 like bZIP transcription factor 2 Homo sapiens 181-224 23781297-0 2013 Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates. Isothiocyanates 141-156 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 23403058-0 2013 Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Isothiocyanates 44-59 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 23836589-0 2013 Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFkappaB activation. Isothiocyanates 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 93-97 24454992-3 2013 In vitro and in vivo studies suggest a chemopreventive activity of isothiocyanates through the redox-sensitive transcription factor Nrf2. Isothiocyanates 67-82 NFE2 like bZIP transcription factor 2 Homo sapiens 132-136 23781297-3 2013 Natural ITCs are key chemopreventive ingredients of cruciferous vegetables, and one of the prime chemopreventive mechanisms of natural isothiocyanates is the induction of Nrf2/ARE-dependent gene expression that plays a critical role in cellular defense against electrophiles and reactive oxygen species. Isothiocyanates 135-150 NFE2 like bZIP transcription factor 2 Homo sapiens 171-175 22527941-1 2012 Isothiocyanates, among which alyssin is counted, are the compounds that have proved chemopreventive properties and the ability to induce the 2 and the 3 detoxification phase by affecting the transcription factor nuclear erythroid 2-related factor (Nrf2). Isothiocyanates 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 248-252 22377900-7 2012 Isothiocyanates, sulfur-containing phytochemicals present in cruciferous plants, are well known to target Keap1 for activating the transcription factor Nrf2 for inducing self-defensive and anti-oxidative gene expression. Isothiocyanates 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 20368435-7 2010 Our results show that compounds containing alpha-beta unsaturated carbonyls, sulfhydryl reactive metals, and isothiocyanates are strong activators of Nrf2 in a reporter assay system and in primary human CLL based on increased expression of the Nrf2 target heme oxygenase-1. Isothiocyanates 109-124 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 21656528-2 2011 The aim of this study was to examine the potential activation and synergism of Nrf2-ARE-mediated transcriptional activity between four common phytochemicals present in cruciferous vegetables; the indoles: indole-3-carbinol (I3C), 3,3"-diindolylmethane (DIM); and the isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC) and sulforaphane (SFN). Isothiocyanates 267-282 NFE2 like bZIP transcription factor 2 Homo sapiens 79-83 21656528-2 2011 The aim of this study was to examine the potential activation and synergism of Nrf2-ARE-mediated transcriptional activity between four common phytochemicals present in cruciferous vegetables; the indoles: indole-3-carbinol (I3C), 3,3"-diindolylmethane (DIM); and the isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC) and sulforaphane (SFN). Isothiocyanates 284-288 NFE2 like bZIP transcription factor 2 Homo sapiens 79-83 22178957-3 2012 The nuclear factor-erythroid-2-related factor 2 system, which orchestrates the expression of a wide array of antioxidant genes, plays a role in the protective effect of isothiocyanates against almost all the pathological conditions reported above. Isothiocyanates 169-184 NFE2 like bZIP transcription factor 2 Homo sapiens 4-47 20368435-7 2010 Our results show that compounds containing alpha-beta unsaturated carbonyls, sulfhydryl reactive metals, and isothiocyanates are strong activators of Nrf2 in a reporter assay system and in primary human CLL based on increased expression of the Nrf2 target heme oxygenase-1. Isothiocyanates 109-124 NFE2 like bZIP transcription factor 2 Homo sapiens 244-248 16506816-5 2006 These results show that different individual isothiocyanates may possess some different activities in nuclear accumulation of thioredoxin, NF-kappaB, Nrf2, and production of ROS. Isothiocyanates 45-60 NFE2 like bZIP transcription factor 2 Homo sapiens 150-154 18458837-5 2008 Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively. Isothiocyanates 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 210-214 16928811-0 2006 Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2. Isothiocyanates 23-38 NFE2 like bZIP transcription factor 2 Homo sapiens 175-179 18048326-1 2007 Isothiocyanates and phenolic antioxidants can prevent cancer through activation of Nrf2 (NF-E2 p45-related factor 2), a transcription factor that controls expression of cytoprotective genes through the antioxidant response element (ARE) enhancer. Isothiocyanates 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 83-87 18048326-1 2007 Isothiocyanates and phenolic antioxidants can prevent cancer through activation of Nrf2 (NF-E2 p45-related factor 2), a transcription factor that controls expression of cytoprotective genes through the antioxidant response element (ARE) enhancer. Isothiocyanates 0-15 NFE2 like bZIP transcription factor 2 Homo sapiens 89-115