PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9430725-4	1998	An inhibitor of the caspase/interleukin-1 beta-converting enzyme blocked isothiocyanate-induced apoptosis without inhibiting the JNK activation, which suggests that JNK activation by isothiocyanates is an event that is independent or upstream of the activation of caspase/interleukin-1 beta-converting enzyme proteases.	Isothiocyanates	183-198	mitogen-activated protein kinase 8	Homo sapiens	165-168	
15139522-11	2004	The JNK activity was induced by the isothiocyanates and EGCG.	Isothiocyanates	36-51	mitogen-activated protein kinase 8	Homo sapiens	4-7	
12171915-1	2002	Dietary isothiocyanates induce apoptosis in various cancer cell lines through a c-Jun N-terminal kinase (JNK)-dependent mechanism.	Isothiocyanates	8-23	mitogen-activated protein kinase 8	Homo sapiens	80-103	
12171915-1	2002	Dietary isothiocyanates induce apoptosis in various cancer cell lines through a c-Jun N-terminal kinase (JNK)-dependent mechanism.	Isothiocyanates	8-23	mitogen-activated protein kinase 8	Homo sapiens	105-108	
10397596-4	1999	At lower concentration, phenolic antioxidants and isothiocyanates activate mitogen-activated protein kinase (MAPK; extracellular signal-regulated protein kinase 2, ERK2; and c-Jun N-terminal kinase 1, JNK1) in a concentration-and time-dependent manner.	Isothiocyanates	50-65	mitogen-activated protein kinase 8	Homo sapiens	174-199	
10397596-4	1999	At lower concentration, phenolic antioxidants and isothiocyanates activate mitogen-activated protein kinase (MAPK; extracellular signal-regulated protein kinase 2, ERK2; and c-Jun N-terminal kinase 1, JNK1) in a concentration-and time-dependent manner.	Isothiocyanates	50-65	mitogen-activated protein kinase 8	Homo sapiens	201-205	
9430725-0	1998	Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates.	Isothiocyanates	95-110	mitogen-activated protein kinase 8	Homo sapiens	24-47	
9430725-3	1998	The sustained JNK activation caused by isothiocyanates was associated with apoptosis induction in various cell types.	Isothiocyanates	39-54	mitogen-activated protein kinase 8	Homo sapiens	14-17	
11984078-11	2002	Isothiocyanates also induced apoptosis of pre-cancerous cells and tumor cells activated by caspase-8 and potentiated by JNK1.	Isothiocyanates	0-15	mitogen-activated protein kinase 8	Homo sapiens	120-124	
11237388-0	2001	Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK.	Isothiocyanates	60-75	mitogen-activated protein kinase 8	Homo sapiens	145-148	
8674048-9	1996	Furthermore, different patterns of JNK1 induction by these isothiocyanates may contribute to their distinct chemopreventive efficacies in some animal tumor model studies.	Isothiocyanates	59-74	mitogen-activated protein kinase 8	Homo sapiens	35-39	
26397194-0	2015	Isothiocyanates inhibit the invasion and migration of C6 glioma cells by blocking FAK/JNK-mediated MMP-9 expression.	Isothiocyanates	0-15	mitogen-activated protein kinase 8	Homo sapiens	86-89	
16272172-0	2006	ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.	Isothiocyanates	118-133	mitogen-activated protein kinase 8	Homo sapiens	8-11	
8674048-7	1996	When comparing the kinetics of JNK1 activation by different isothiocyanates, PEITC elicited a sustained activation, whereas 3-phenylpropyl isothiocyanate and 4-phenylbutyl isothiocyanate stimulated transient activations.	Isothiocyanates	60-75	mitogen-activated protein kinase 8	Homo sapiens	31-35	
16928811-0	2006	Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2.	Isothiocyanates	23-38	mitogen-activated protein kinase 8	Homo sapiens	118-121