PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19082476-9 2009 EVOO lignans and secoiridoids prevented HER2-induced in vitro transformed phenotype as they inhibited colony formation of MCF10A/HER2 cells in soft-agar. Agar 148-152 erb-b2 receptor tyrosine kinase 2 Homo sapiens 40-44 25526094-5 2015 ErbB2 and EGFR knockdown in KPL-4 and SUM149 cells, respectively, causes decreased colony growth in soft agar and increased caspase activation following ECM detachment. Agar 105-109 erb-b2 receptor tyrosine kinase 2 Homo sapiens 0-5 21787752-6 2011 Overexpression of erbB2 enabled breast epithelial cells to grow anchorage-independently in soft agar, and the transfection of the precursor of miR-205 into the cells leaded to the decrease in the ability to grow in soft agar. Agar 96-100 erb-b2 receptor tyrosine kinase 2 Homo sapiens 18-23 19082476-9 2009 EVOO lignans and secoiridoids prevented HER2-induced in vitro transformed phenotype as they inhibited colony formation of MCF10A/HER2 cells in soft-agar. Agar 148-152 erb-b2 receptor tyrosine kinase 2 Homo sapiens 129-133 11313890-5 2001 Colony formation in soft agar was enhanced by HRG in three of five cell lines tested, a response that correlated with the presence of a c-Src/HER2 heterocomplex. Agar 25-29 erb-b2 receptor tyrosine kinase 2 Homo sapiens 142-146 17612563-6 2007 RESULTS: We found that, in the absence of EGF, p38MAPK-activated AKT is necessary for HER-2 overexpressing cells to survive and to form colonies in soft agar. Agar 153-157 erb-b2 receptor tyrosine kinase 2 Homo sapiens 86-91 17376931-5 2007 The increased colony formation capacity in soft agar was associated with increased expression and activation of HER2/HER3 signaling cascades, as evidenced by the findings that the treatment of HER2 antibody trastuzumab (Herceptin), phosphatidylinositol 3-kinase inhibitor, or MEK inhibitor completely abolished the tumorigenic capacity. Agar 48-52 erb-b2 receptor tyrosine kinase 2 Homo sapiens 112-116 17376931-5 2007 The increased colony formation capacity in soft agar was associated with increased expression and activation of HER2/HER3 signaling cascades, as evidenced by the findings that the treatment of HER2 antibody trastuzumab (Herceptin), phosphatidylinositol 3-kinase inhibitor, or MEK inhibitor completely abolished the tumorigenic capacity. Agar 48-52 erb-b2 receptor tyrosine kinase 2 Homo sapiens 193-197 17146442-4 2007 HCK1T-E6E7 showed impaired contact inhibition and anchorage-independent growth in soft agar which were abrogated with introduction of ErbB2-specific short hairpin RNA (shRNA) or an ErbB2 specific inhibitor AG825. Agar 87-91 erb-b2 receptor tyrosine kinase 2 Homo sapiens 134-139 17146442-4 2007 HCK1T-E6E7 showed impaired contact inhibition and anchorage-independent growth in soft agar which were abrogated with introduction of ErbB2-specific short hairpin RNA (shRNA) or an ErbB2 specific inhibitor AG825. Agar 87-91 erb-b2 receptor tyrosine kinase 2 Homo sapiens 181-186 11360194-5 2001 HER2-ECD overexpression decreased spontaneous proliferation of MCF7 cells as well as heregulin-mediated soft agar colony formation. Agar 109-113 erb-b2 receptor tyrosine kinase 2 Homo sapiens 0-4 10797285-5 2000 In SK-OV-3 cells, ErbB-2 expression conferred a growth advantage and soft agar experiments revealed that ErbB-2 was rate-limiting for anchorage-independent growth. Agar 74-78 erb-b2 receptor tyrosine kinase 2 Homo sapiens 105-111 10962438-6 2000 The MEK inhibitor PD98059 and anti-erbB-2 MAb L26 also suppressed colony formation of Ha-ras transformed cells in soft agar. Agar 119-123 erb-b2 receptor tyrosine kinase 2 Homo sapiens 35-41 9735325-4 1998 Activation of c-src appeared to be dependent on active ErbB2 tyrosine kinase, as the ErbB2 inhibitor tyrphostin AG 825 blocked the induction of c-src kinase activity, as well as the ability of transformed cells to grow on soft agar, but not plastic. Agar 227-231 erb-b2 receptor tyrosine kinase 2 Homo sapiens 55-60 9735325-5 1998 The src-selective inhibitor PP1 effectively reduced c-src activity, as well as growth of ErbB2-transformed cells on soft agar, but not on plastic. Agar 121-125 erb-b2 receptor tyrosine kinase 2 Homo sapiens 89-94 9685225-3 1998 In the absence of HRG, inhibition of erbB2 expression slowed cell growth, leading to accumulation of cells in the G2/M phase, and suppressed colony growth in soft agar. Agar 163-167 erb-b2 receptor tyrosine kinase 2 Homo sapiens 37-42 9096379-5 1997 In EGFr-positive U87MG human glioblastoma cells, expression of the Neu ectodomain inhibits EGF-, but not platelet-derived growth factor-, induced DNA synthesis; inhibits cell proliferation in the presence of EGF, but not platelet-derived growth factor; inhibits the ability of U87MG to form colonies in soft agar; and inhibits transforming efficiency in athymic mice. Agar 308-312 erb-b2 receptor tyrosine kinase 2 Homo sapiens 67-70 9087165-6 1997 In addition, p185erbB2(V-E) expressing cells displayed a reduced ability to grow in soft agar compared to the parental cell line. Agar 89-93 erb-b2 receptor tyrosine kinase 2 Homo sapiens 13-22 1981145-7 1990 Addition of an anti-c-erbB-2 monoclonal antibody inhibits the anchorage-independent growth of these cells in soft agar. Agar 114-118 erb-b2 receptor tyrosine kinase 2 Homo sapiens 20-28