PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11360194-5	2001	HER2-ECD overexpression decreased spontaneous proliferation of MCF7 cells as well as heregulin-mediated soft agar colony formation.	Agar	109-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4	
19082476-9	2009	EVOO lignans and secoiridoids prevented HER2-induced in vitro transformed phenotype as they inhibited colony formation of MCF10A/HER2 cells in soft-agar.	Agar	148-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	40-44	
19082476-9	2009	EVOO lignans and secoiridoids prevented HER2-induced in vitro transformed phenotype as they inhibited colony formation of MCF10A/HER2 cells in soft-agar.	Agar	148-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	129-133	
17146442-4	2007	HCK1T-E6E7 showed impaired contact inhibition and anchorage-independent growth in soft agar which were abrogated with introduction of ErbB2-specific short hairpin RNA (shRNA) or an ErbB2 specific inhibitor AG825.	Agar	87-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	134-139	
17146442-4	2007	HCK1T-E6E7 showed impaired contact inhibition and anchorage-independent growth in soft agar which were abrogated with introduction of ErbB2-specific short hairpin RNA (shRNA) or an ErbB2 specific inhibitor AG825.	Agar	87-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	181-186	
17612563-6	2007	RESULTS: We found that, in the absence of EGF, p38MAPK-activated AKT is necessary for HER-2 overexpressing cells to survive and to form colonies in soft agar.	Agar	153-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-91	
17376931-5	2007	The increased colony formation capacity in soft agar was associated with increased expression and activation of HER2/HER3 signaling cascades, as evidenced by the findings that the treatment of HER2 antibody trastuzumab (Herceptin), phosphatidylinositol 3-kinase inhibitor, or MEK inhibitor completely abolished the tumorigenic capacity.	Agar	48-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	112-116	
17376931-5	2007	The increased colony formation capacity in soft agar was associated with increased expression and activation of HER2/HER3 signaling cascades, as evidenced by the findings that the treatment of HER2 antibody trastuzumab (Herceptin), phosphatidylinositol 3-kinase inhibitor, or MEK inhibitor completely abolished the tumorigenic capacity.	Agar	48-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	193-197	
11313890-5	2001	Colony formation in soft agar was enhanced by HRG in three of five cell lines tested, a response that correlated with the presence of a c-Src/HER2 heterocomplex.	Agar	25-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	142-146	
1981145-7	1990	Addition of an anti-c-erbB-2 monoclonal antibody inhibits the anchorage-independent growth of these cells in soft agar.	Agar	114-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	20-28	
10962438-6	2000	The MEK inhibitor PD98059 and anti-erbB-2 MAb L26 also suppressed colony formation of Ha-ras transformed cells in soft agar.	Agar	119-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-41	
9685225-3	1998	In the absence of HRG, inhibition of erbB2 expression slowed cell growth, leading to accumulation of cells in the G2/M phase, and suppressed colony growth in soft agar.	Agar	163-167	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-42	
9096379-5	1997	In EGFr-positive U87MG human glioblastoma cells, expression of the Neu ectodomain inhibits EGF-, but not platelet-derived growth factor-, induced DNA synthesis; inhibits cell proliferation in the presence of EGF, but not platelet-derived growth factor; inhibits the ability of U87MG to form colonies in soft agar; and inhibits transforming efficiency in athymic mice.	Agar	308-312	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-70	
9087165-6	1997	In addition, p185erbB2(V-E) expressing cells displayed a reduced ability to grow in soft agar compared to the parental cell line.	Agar	89-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-22	
10797285-5	2000	In SK-OV-3 cells, ErbB-2 expression conferred a growth advantage and soft agar experiments revealed that ErbB-2 was rate-limiting for anchorage-independent growth.	Agar	74-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	105-111	
9735325-4	1998	Activation of c-src appeared to be dependent on active ErbB2 tyrosine kinase, as the ErbB2 inhibitor tyrphostin AG 825 blocked the induction of c-src kinase activity, as well as the ability of transformed cells to grow on soft agar, but not plastic.	Agar	227-231	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-60	
9735325-5	1998	The src-selective inhibitor PP1 effectively reduced c-src activity, as well as growth of ErbB2-transformed cells on soft agar, but not on plastic.	Agar	121-125	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-94	
25526094-5	2015	ErbB2 and EGFR knockdown in KPL-4 and SUM149 cells, respectively, causes decreased colony growth in soft agar and increased caspase activation following ECM detachment.	Agar	105-109	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5	
21787752-6	2011	Overexpression of erbB2 enabled breast epithelial cells to grow anchorage-independently in soft agar, and the transfection of the precursor of miR-205 into the cells leaded to the decrease in the ability to grow in soft agar.	Agar	96-100	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-23