PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3823818-6	1986	The small number of strains resistant to nalidixic acid (2/107) suggests that agents inhibiting DNA gyrase may be useful for self-administered treatment during travel as well as upon return.	Nalidixic Acid	41-55	DNA topoisomerase II alpha	Homo sapiens	96-106	
2546584-1	1989	Although the functional target of quinolone antibacterials such as nalidixic acid and norfloxacin has been identified as the enzyme DNA gyrase, the direct binding site of the drug is the DNA molecule [Shen, L. L., & Pernet, A. G. (1985) Proc.	Nalidixic Acid	67-81	DNA topoisomerase II alpha	Homo sapiens	132-142	
2539998-2	1989	In microbial systems, nalidixic acid is known to disrupt the function of a topoisomerase-like enzyme, DNA gyrase.	Nalidixic Acid	22-36	DNA topoisomerase II alpha	Homo sapiens	102-112	
2539998-12	1989	This suggestion is based in part on the known effect of the analog nalidixic acid on DNA gyrase in microbial cells and on topoisomerase in mammalian cells.	Nalidixic Acid	67-81	DNA topoisomerase II alpha	Homo sapiens	85-95	
2982149-0	1985	Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.	Nalidixic Acid	54-68	DNA topoisomerase II alpha	Homo sapiens	27-37	
227861-3	1979	Coumermycin, novobiocin, nalidixic acid, and oxolinic acid are known to be inhibitors of Escherichia coli gyrase, to inhibit E. coli DNA replication, to abolish colicin E1 replication, and to depress the supercoiling of phage lambda DNA, the last two via inhibition of the DNA gyrase.	Nalidixic Acid	25-39	DNA topoisomerase II alpha	Homo sapiens	273-283